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Genomic analysis of the causative agents of coccidiosis in domestic chickens

Lookup NU author(s): Dr Diego Miranda Saavedra

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.


Publication metadata

Author(s): Reid AJ, Blake DP, Ansari HR, Billington K, Browne HP, Bryant J, Dunn M, Hung SS, Kawahara F, Miranda-Saavedra D, Malas TB, Mourier T, Naghra H, Nair M, Otto TD, Rawlings ND, Rivailler P, Sanchez-Flores A, Sanders M, Subramaniam C, Tay YL, Woo Y, Wu XK, Barrell B, Dear PH, Doerig C, Gruber A, Ivens AC, Parkinson J, Rajandream MA, Shirley MW, Wan KL, Berriman M, Tomley FM, Pain A

Publication type: Article

Publication status: Published

Journal: Genome Research

Year: 2014

Volume: 24

Issue: 10

Pages: 1676-1685

Print publication date: 01/10/2014

Online publication date: 11/07/2014

Acceptance date: 08/07/2014

Date deposited: 19/11/2014

ISSN (print): 1088-9051

ISSN (electronic): 1549-5469

Publisher: Cold Spring Harbor Laboratory Press

URL: http://dx.doi.org/10.1101/gr.168955.113

DOI: 10.1101/gr.168955.113


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Funding

Funder referenceFunder name
King Abdullah University of Science and Technology (KAUST)
Wellcome Trust
07-05-16-MGI-GMB10Ministry of Science, Technology and Innovation, Malaysia
DIP-2012-21Universiti Kebangsaan Malaysia
MOP84556Canadian Institute for Health Research (CIHR)
S19705/6BBSRC
S17413BBSRC

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