Normal and abnormal development of the heart

Anderson, RH; Moorman, AFM; Brown, NA; Bamforth, SD; Chaudhry, B; Henderson, DJ; Mohun, TJ

doi:10.1007/978-1-4471-4619-3_153

Normal and abnormal development of the heart

Lookup NU author(s): Professor Bob Anderson, Dr Simon Bamforth ORCiD, Dr Bill Chaudhry, Professor Deborah Henderson ORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© Springer-Verlag London 2014.Accurate knowledge of embryology is essential for interpretation of congenital cardiac malformations. Recent advances made in the understanding of cardiac development now make it possible to appreciate the morphology of not only the normal heart but also many congenital cardiac malformations. This is true not only for the molecular mechanisms that might lead to the malformations but also for the structure of the normal and abnormally developing heart. In this chapter, we discuss the progress made in demonstrating the structure of the developing heart, along with knowledge of the changes that occur in the expression of the genes and their products, which control the formation and differentiation of its various components.