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Assisted reproductive technologies at the nexus of fertility treatment and disease prevention

Lookup NU author(s): Professor Mary Herbert, Dr Meenakshi Choudhary

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Abstract

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen embryos for inherited genetic disorders of the nuclear and mitochondrial genomes. Progress in identifying causative genetic variants has massively increased the scope of preimplantation genetic testing in preventing genetic disorders. However, because ART procedures are not without risk of adverse maternal and child outcomes, careful consideration of the balance of risks and benefits is warranted. Further research on early human development will help to minimize risks while maximizing the benefits of ART.

Publication metadata

Author(s): Herbert M, Choudhary M, Zander-Fox D

Publication type: Review

Publication status: Published

Journal: Science

Year: 2023

Volume: 380

Issue: 6641

Pages: 164-167

Print publication date: 14/04/2023

Acceptance date: 07/03/2023

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: NLM (Medline)

URL: https://doi.org/10.1126/science.adh0073

DOI: 10.1126/science.adh0073

PubMed id: 37053308

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