Browse by author
Lookup NU author(s): Dr Bridget Griffiths
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
VC The Author(s) 2022. Objective. To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined. Methods. This was a multicentre longitudinal study. Patients were recruited within 12 months of achieving fourth ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1 January 2005 to 31 December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage. Results. A total of 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4 months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3 years before stabilizing at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95% CI: 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states [BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA] were inversely associated with development of damage. Conclusions. BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets.
Author(s): Yee C-S, Gordon C, Akil M, Lanyon P, Edwards CJ, Isenberg DA, Rahman A, Teh L-S, Tosounidou S, Stevens R, Prabu A, Griffiths B, McHugh N, Bruce IN, Ahmad Y, Khamashta MA, Farewell VT
Publication type: Article
Publication status: Published
Journal: Rheumatology
Year: 2023
Volume: 62
Issue: 2
Pages: 668-675
Print publication date: 01/02/2023
Online publication date: 10/06/2022
Acceptance date: 29/05/2022
ISSN (print): 1462-0324
ISSN (electronic): 1462-0332
Publisher: Oxford University Press
URL: https://doi.org/10.1093/rheumatology/keac334
DOI: 10.1093/rheumatology/keac334
PubMed id: 35686924
Altmetrics provided by Altmetric
