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Targeting poly(ADP-ribose) polymerase: A two-armed strategy for cancer therapy

Lookup NU author(s): Professor Ruth Plummer, Professor Alan Calvert

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Abstract

The DNA repair pathways are protective of the host genome in normal cells; however, in cancer cells, these pathways may be disrupted and predispose to tumorigenesis or their activity may overcome the potentially cytotoxic damage caused by anticancer agents and be a mechanism of resistance. Poly(ADP-ribose) polymerase inhibitors, which block base excision repair of single-strand breaks, have entered the clinic in the last few years. This article discusses the interactions between the pathways of single- and double-strand break repair, which explain the two clinical development strategies for this class of drugs. ©2007 American Association for Cancer Research.

Publication metadata

Author(s): Plummer ER, Calvert AH

Publication type: Article

Publication status: Published

Journal: Clinical Cancer Research

Year: 2007

Volume: 13

Issue: 21

Pages: 6252-6256

Print publication date: 01/11/2007

ISSN (print): 1078-0432

ISSN (electronic): 1557-3265

URL: http://dx.doi.org/10.1158/1078-0432.CCR-07-0617

DOI: 10.1158/1078-0432.CCR-07-0617

PubMed id: 17975135

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