Publications by Dr Louise Reynard - ePrints

Browsing publications by Dr Louise Reynard.

Newcastle Authors	Title	Year
Saad Aldalaqan Caroline Dalgliesh Dr Sara Luzzi Chile Siachisumo Dr Louise Reynard et al.	Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases	2022
Dr Faye Cooles Dr Jessica Tarn Dr Dennis Lendrem Najib Naamane Alice Lin et al.	Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming	2022
Dr Richard Howey Alex Clark Najib Naamane Dr Louise Reynard Dr Arthur Pratt et al.	A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships	2021
Dr Matthew Barter Dr Catherine Bui Kat Cheung Julia Falk Dr Rodolfo Gomez et al.	DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions	2020
Kat Cheung Dr Matthew Barter Julia Falk Dr Carole Proctor Dr Louise Reynard et al.	Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity	2020
Alex Clark Dr Amy Anderson Dr Nishanthi Thalayasingam Najib Naamane Julie Diboll et al.	Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci	2020
Sam Charlton Kat Cheung Yao Hao Dr Jamie Soul Dr Louise Reynard et al.	microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs	2020
Kat Cheung Marjolein Burgers Professor David Young Dr Simon Cockell Dr Louise Reynard et al.	Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage	2019
Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin	Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals	2019
Dr Colin Shepherd Abi Reese Dr Louise Reynard Professor John Loughlin	Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP	2019
Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin	Identification and analysis of novel methylation quantitative trait loci (mQTLs) in osteoarthritis	2019
Dr Louise Reynard Dr Matthew Barter	Osteoarthritis year in review 2019: genetics, genomics and epigenetics	2019
Dr Sarah Rice Maria Tselepi Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd et al.	Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci	2019
Dr Nishanthi Thalayasingam Andrew Skelton Dr Amy Anderson Alex Clark Julie Diboll et al.	CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification	2018
Chris Macdonald Dr Adrian Falconer Dr Chun Chan Dr David Wilkinson Andrew Skelton et al.	Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes	2018
Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al.	Functional characterization of the osteoarthritis genetic risk residing at ALDH1A2 identifies rs12915901 as a key target variant.	2018
Dr Colin Shepherd Dr Louise Reynard Professor John Loughlin	Genotype at the MGP OA risk locus correlates with an expression quantitative trait locus operating on MGP in cartilage and with DNA methylation at a cluster of regulatory CpGs within ARHGDIB	2018
Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Dr David Almarza Gomez Maria Tselepi et al.	Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk	2018
Dr Sarah Rice Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd Maria Tselepi et al.	Identification of novel methylation quantitative trait loci (mqtls) and functional characterization using CRISPR/CAS9 and gene expression analysis prioritizes PLEC as an OA risk gene	2018
Dr Madhushika Ratnayake Maria Tselepi Dr Louise Reynard Professor John Loughlin	A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5	2017
Dr Louise Reynard	Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?	2017
Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Professor David Deehan Professor John Loughlin et al.	Epigenetic and transcriptional effects operate on the SUPT3H and RUNX2 genes residing at the chromosome 6p21.1 osteoarthritis susceptibility locus and correlate with the association signal	2017
Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al.	Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs	2017
Dr Louise Reynard Andrew Skelton David Young Professor John Loughlin	The first international workshop on the epigenetics of osteoarthritis	2017
Dr Louise Reynard Dr Amanda Villalvilla Garcia Professor John Loughlin	Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis	2017
Andrew Skelton Dr Rodolfo Gomez Professor John Loughlin Dr Louise Reynard	Age-related DNA methylation changes in normal and osteoarthritis cartilage	2016
Dr Tarana Singh Dang Dr Joe Willet Helen Griffin Dr Graeme O'Boyle Dr Mario Abinun et al.	Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency	2016
Maria Tselepi Madhushika Ratnayake Dr Louise Reynard Professor John Loughlin	Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation	2016
Dr Amanda Villalvilla Garcia Dr Fiona Gee Professor John Loughlin Dr Louise Reynard	DNA methylation in the 20q13 OA susceptibility region marked by rs6094710 is associated with modulation of NCOA3 gene expression	2016
Dr Tarana Singh Dang Dr Joe Willet Helen Griffin Dr Graeme O'Boyle Dr Mario Abinun et al.	Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency (vol 36, pg 117, 2016)	2016
Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al.	Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874	2016
Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin	Functional characterization of the osteoarthritis susceptibility mapping to CHST11 - a bioinformatics and molecular study	2016
Emma Rogers Dr Louise Reynard Dr Kenneth Rankin Professor John Loughlin	Functional Investigation of an OA susceptibility locus at chromsome 9q33.1 associated with female hip osteoarthritis	2016
Dr Arthur Pratt Dr Amy Anderson Julie Diboll Andrew Skelton Dr Dennis Lendrem et al.	Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients	2016
Dr Louise Reynard Professor John Loughlin	Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells	2016
Dr Fiona Gee Dr Michael Rushton Professor John Loughlin Dr Louise Reynard	Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380	2015
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard	Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients	2015
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard	Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients	2015
Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al.	Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874	2015
Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin	Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591	2015
Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Rebecca Darlay et al.	Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci	2015
Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Fiona Gee et al.	Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk	2015
Professor John Loughlin Dr Louise Reynard	Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA	2015
Professor John Loughlin Dr Louise Reynard	Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA	2015
Dr Louise Reynard Professor John Loughlin	The carbohydrate sulfotransferase gene CHST11 is regulated by DNA methylation which impacts on the functional effect of the OA generic susceptibility residing at this locus	2015
Emma Rogers Dr Louise Reynard Professor John Loughlin	The role of inflammation-related genes in osteoarthritis	2015
Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al.	Allelic expression analysis of genes from within the osteoarthritis susceptibility locus at chromosome 3p21 reveals functional gene expression effects at GNL3 and SPCS1 that correlate with the association signal	2014
Dr Fiona Gee Clare Clubbs Emma Raine Dr Louise Reynard Professor John Loughlin et al.	Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1	2014
Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al.	Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1	2014
Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Dr Kenneth Rankin Professor David Young et al.	Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis	2014
Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Ramsay Refaie Dr Kenneth Rankin et al.	Characterization of the cartilage DNA methylome in knee and hip osteoarthritis	2014
Dr Louise Reynard Dr Catherine Bui Catherine Syddall Professor John Loughlin	CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383	2014
Dr David McDonald Dr Bernadette Carroll Nicholas Robertson Dr Helen Griffin Professor Jeremy Lakey et al.	Dual Proteolytic Pathways Govern Glycolysis and Immune Competence	2014
Emma Rogers Dr Louise Reynard Dr Kate Rennie Professor John Loughlin	Expression analysis of osteoarthritis associated genes in mesenchymal stem cells differentiating into joint-associated cells	2014
Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin	Functional analysis of the osteoarthritis susceptibility locus marked by the polymorphism rs10492367	2014
Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin	Functional analysis of the osteoarthritis susceptibility locus residing at the carbohydrate sulfotransferase 11 gene CHST11	2014
Emma Raine Dr Louise Reynard Professor John Loughlin	Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome	2014
Dr Emma Raine Dr Louise Reynard Professor John Loughlin	Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome	2014
Dr Michael Rushton Dr Fiona Gee Dr Louise Reynard Professor John Loughlin	The osteoarthritis association marked by SNP rs6094710 mediates its effect by reducing the expression of NCOA3 in joint tissues	2014
Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin	Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues	2013
Dr Louise Reynard Professor John Loughlin	Insights from human genetic studies into the pathways involved in osteoarthritis	2013
Dr Louise Reynard Professor John Loughlin	The genetics and functional analysis of primary osteoarthritis susceptibility	2013
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383	2013
Andrew Dodd Dr Emma Raine Dr Louise Reynard Professor John Loughlin	Allelic expression analysis in patient issues of the osteoarthritis and of the lumbar disc herniation susceptibility loci that map to COL11A1	2012
Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al.	Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3	2012
Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al.	Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3	2012
Dr Madhushika Ratnayake Dr Louise Reynard Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al.	Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3	2012
Dr Emma Raine Dr Louise Reynard Professor John Loughlin	Allelic expression analysis, and association with OA, of common variants in SMAD3	2012
Professor Sophie Hambleton Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard et al.	Autosomal recessive combines immunodeficiency due to loss of function mutation in Tripeptidyl Peptidase II	2012
Dr Catherine Bui Dr Matthew Barter Jenny Scott Dr Martin Galler Dr Louise Reynard et al.	cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis	2012
Professor Matthew Collin Dr Rachel Dickinson Professor Muzlifah Haniffa Dr Naomi McGovern Dr Helen Griffin et al.	Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation	2012
Dr Louise Reynard Professor John Loughlin	Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22	2012
Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin	Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22	2012
Dr Louise Reynard Professor John Loughlin	Genetics and epigenetics of osteoarthritis	2012
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs143383	2012
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS143383	2012
Dr Louise Reynard Catherine Syddall Professor John Loughlin	The osteoarthritis susceptibility gene GDF5 is under epigenetic regulation by DNA methylation - the molecular interplay between genetics and epigenetics in disease risk	2012
Dr Helen Griffin Dr David McDonald Dr Rachel Dickinson Angela Grainger Dr Louise Reynard et al.	Whole exome sequencing as a diagnostic tool in primary immunodeficiency	2012
Andrew Dodd Dr Louise Reynard Professor John Loughlin	Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus	2011
Dr Rachel Dickinson Dr Helen Griffin Dr Venetia Bigley Dr Louise Reynard Raf Hussain et al.	Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency	2011
Dr Louise Reynard Dr Catherine Bui Professor David Young Professor John Loughlin	Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation	2011
Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard Professor John Loughlin et al.	Whole-exome deep sequencing identifies a novel causative mutation in primary immunodeficiency	2011
Dr Louise Reynard Athanasia Gravani Professor John Loughlin	The osteoarthritis-associated gene GDF5 is under epigenetic regulation in patient tissues and in a range of human cell lines	2010
Dr Louise Reynard	Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.	2009
Dr Louise Reynard	The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein	2009
Dr Louise Reynard	Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR	2007