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Lookup NU author(s): Professor Anthony De SoyzaORCiD
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BACKGROUND: The specific attributes of inhaler devices can influence patient use, satisfaction and treatment compliance, and may ultimately impact on clinical outcomes in patients with chronic obstructive pulmonary disease (COPD).AIMS: To assess patient preference, satisfaction and critical inhaler technique errors with Genuair (a multidose inhaler) and Breezhaler (a single-dose inhaler) after 2 weeks of daily use.METHODS: Patients with COPD and moderate to severe airflow obstruction were randomised in a cross-over, open-label, multicentre study to consecutive once-daily inhalations of placebo via Genuair and Breezhaler, in addition to current COPD medication. The primary end point was the proportion of patients who preferred Genuair versus Breezhaler after 2 weeks (Patient Satisfaction and Preference Questionnaire). Other end points included overall satisfaction and correct use of the inhalers after 2 weeks, and willingness to continue with each device.RESULTS: Of the 128 patients enrolled, 127 were included in the safety population (male n = 91; mean age 67.6 years). Of the 110 of the 123 patients in the intent-to-treat population who indicated an inhaler preference, statistically significantly more patients preferred Genuair than Breezhaler (72.7 vs. 27.3%; P < 0.001). Mean overall satisfaction scores were also greater for Genuair than for Breezhaler (5.9 vs. 5.3, respectively; P < 0.001). After 2 weeks, there was no statistically significant difference in the number of patients who made >= 1 critical inhaler technique error with Breezhaler than with Genuair (7.3 vs. 3.3%, respectively).CONCLUSIONS: Patient overall preference and satisfaction was significantly higher with Genuair compared with Breezhaler. The proportion of patients making critical inhaler technique errors was low with Genuair and Breezhaler.
Author(s): Pascual S, Feimer J, De Soyza A, Roig JS, Haughney J, Padulles L, Seoane B, Rekeda L, Ribera A, Chrystyn H
Publication type: Article
Publication status: Published
Journal: NPJ Primary Care Respiratory Medicine
Online publication date: 30/04/2015
Acceptance date: 03/02/2015
ISSN (electronic): 2055-1010
Publisher: Nature Publishing Group
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