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Vascular ageing: Underlying mechanisms and clinical implications

Lookup NU author(s): Professor Konstantinos StellosORCiD

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Abstract

© 2017 Elsevier Inc. Epidemiological studies have shown that ageing is a major non-reversible risk factor for cardiovascular disease. Vascular ageing starts early in life and is characterized by a gradual change of vascular structure and function resulting in increased arterial stiffening. At the present review we discuss the role of the most important molecular pathways involved in vascular ageing, their association with arterial stiffening and possible novel therapeutic targets that may delay this otherwise irreversible degenerating process. Specifically, we discuss the role of oxidative stress, telomere shortening, and ubiquitin proteasome system in endothelial cell senescence and dysfunction in vascular inflammation and in arterial stiffening. Further, we summarize the most important molecular mechanisms regulating vascular ageing including sirtuin 1, telomerase, klotho, JunD, and amyloid beta 1-40 peptide.

Publication metadata

Author(s): Laina A, Stellos K, Stamatelopoulos K

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2017

Volume: 109

Pages: 16-30

Print publication date: 01/08/2018

Online publication date: 15/06/2017

Acceptance date: 12/06/2017

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.exger.2017.06.007

DOI: 10.1016/j.exger.2017.06.007

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