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Lookup NU author(s): Professor Konstantinos StellosORCiD
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© 2015 Wolters Kluwer Health, Inc. Objectives The masking effect (ME) is present in masked hypertensive patients; however, both normotensive and hypertensive individuals may show a similar phenomenon. Previous studies have shown that ME has been associated with left ventricular hypertrophy and microalbuminuria in treated hypertensive patients. The aim of our study was to evaluate the association between the magnitude of systolic ME and the extent of common carotid artery intima-media thickness (CCA-IMT) development in normotensive individuals and untreated masked hypertensive and hypertensive patients. Participants and methods A total of 1154 individuals underwent 24 h ambulatory blood pressure (BP) monitoring and carotid artery ultrasonographic measurements. The final study population included 360 patients with systolic ME (daytime systolic BP higher than office systolic BP). The participants were divided into three groups according to office and daytime BP values: normotensives, masked hypertensives, and hypertensives. Results Masked hypertensives presented significantly higher systolic ME (-14.6 mmHg) than their normotensive (-8.2 mmHg) and hypertensive (-9.5 mmHg) counterparts. However, systolic ME was associated significantly with CCA-IMT only in the group of masked hypertensives (r=-0.399, P<0.001). The multivariate linear regression analyses showed significant and independent associations of CCA-IMT with the following factors: age (B=0.028, 95% confidence interval: 0.001-0.055; P=0.044) and systolic ME (B=-0.034, 95% confidence interval: -0.066 to -0.003; P=0.034). A 10 mmHg decrease in systolic ME correlated to an increase of 0.034mm in the CCA-IMT. Conclusion Systolic ME was associated significantly with CCA-IMT values in masked hypertensives. Both normotensive and hypertensive participants have failed to show similar associations.
Author(s): Manios E, Michas F, Stamatelopoulos K, Koroboki E, Tsouma I, Stellos K, Vemmos K, Zakopoulos N
Publication type: Article
Publication status: Published
Journal: Blood Pressure Monitoring
Year: 2015
Volume: 20
Issue: 2
Pages: 64-68
Print publication date: 01/04/2015
Acceptance date: 01/04/2015
ISSN (print): 1359-5237
ISSN (electronic): 1473-5725
Publisher: Lippincott Williams and Wilkins
URL: https://doi.org/10.1097/MBP.0000000000000093
DOI: 10.1097/MBP.0000000000000093
PubMed id: 25397594
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