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Association of platelet activation with vascular cognitive impairment: Implications in dementia development?

Lookup NU author(s): Professor Konstantinos StellosORCiD

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Abstract

Cardiovascular risk factors are associated with coronary artery disease (CAD) and with cognitive dysfunction. However, the precise pathogenic mechanisms responsible for this association remain elusive. In the present study, CAD patients with cognitive impairment showed significantly higher platelet activation compared with CAD patients without cognitive impairment. In addition, we identified platelet activity to be a significant independent predictor for the severity of cognitive impairment in these patients. We discuss the link between platelet hyperactivity and dementia (including Alzheimer's disease) based on the literature and our findings. We also discuss the potential mechanisms involved. This link may become a therapeutic option. © 2014 Bentham Science Publishers.

Publication metadata

Author(s): Stellos K, Katsiki N, Tatsidou P, Bigalke B, Laske C

Publication type: Article

Publication status: Published

Journal: Current Vascular Pharmacology

Year: 2014

Volume: 12

Issue: 1

Pages: 152-154

Print publication date: 27/03/2014

Acceptance date: 17/11/2011

ISSN (print): 1570-1611

ISSN (electronic): 1875-6212

Publisher: Bentham Science Publishers B.V.

URL: https://doi.org/10.2174/157016111201140327164641

DOI: 10.2174/157016111201140327164641

PubMed id: 22272899

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