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Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study

Lookup NU author(s): Professor Anthony De SoyzaORCiD


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© 2018. Introduction: Multiple Breath Washout (MBW) to measure Lung Clearance Index (LCI) is increasingly being used as a secondary endpoint in multicentre bronchiectasis studies. LCI data quality control or “over-reading” is resource intensive and the impact is unclear. Objectives: To assess the proportion of MBW tests deemed unacceptable with over-reading, and to assess the change in LCI (number of turnovers), LCI coefficient of variation (CV%) and tidal volume (VT) CV% results after over-reading. Methods: Data were analysed from 250 MBW tests (from 98 adult bronchiectasis patients) collected as part of the Bronch-UK Clinimetrics study in 5 UK centres. Each MBW test was over-read centrally using pre-defined criteria. MBW tests with <2 technically valid and repeatable trials were deemed unacceptable to include in analysis. In accepted tests, values for LCI, LCI CV% and VT CV% before and after over-reading, were compared. Results: Insufficient data was collected in 10/250 tests. With over-reading, 30/240 (12%) were deemed unacceptable to include in analysis. In those accepted tests, overall the change in LCI, LCI CV% and VT CV% with over-reading was not statistically significant. When MBW new sites were compared to MBW expert sites, the change in LCI with over-reading was significantly greater in MBW new sites (p = 0.047). Data suggests that over-reading could be important up to at least 12 months post initiation of MBW activity. Conclusion: MBW over-reading was important in this study as 12% of tests were considered unacceptable. Over-reading improved test result accuracy in sites new to MBW.

Publication metadata

Author(s): O'Neill K, Lakshmipathy GR, Ferguson K, Cosgrove D, Hill AT, Loebinger MR, Carroll M, Chalmers JD, Gatheral T, Johnson C, DeSoyza A, Hurst JR, Bradbury I, Elborn JS, Bradley JM

Publication type: Article

Publication status: Published

Journal: Respiratory Medicine

Year: 2018

Volume: 145

Pages: 206-211

Print publication date: 01/12/2018

Online publication date: 01/11/2018

Acceptance date: 30/10/2018

ISSN (print): 0954-6111

ISSN (electronic): 1532-3064

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.rmed.2018.10.030

PubMed id: 30509710


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