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Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review

Lookup NU author(s): Professor Roderick Skinner

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Abstract

© 2020 Wiley Periodicals LLCWe systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research.


Publication metadata

Author(s): Streefkerk N, Fioole LCE, Beijer JGM, Feijen EAM, Teepen JC, Winther JF, Ronckers CM, Loonen JJ, van Dulmen-den Broeder E, Skinner R, Hudson MM, Tissing WJE, Korevaar JC, Mulder RL, Kremer LCM

Publication type: Review

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2020

Volume: 67

Issue: 11

Print publication date: 01/11/2020

Online publication date: 02/09/2020

Acceptance date: 01/07/2020

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/pbc.28611

DOI: 10.1002/pbc.28611

PubMed id: 32881287


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