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Safety and effectiveness of pre-emptive diabetic vitrectomy in patients with severe, non-fibrotic retinal neovascularisation despite panretinal photocoagulation

Lookup NU author(s): Professor David SteelORCiD


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© 2022, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. Objectives: To investigate the safety and effectiveness of pre-emptive vitrectomy in eyes with severe non-fibrotic proliferative diabetic retinopathy. Methods: A multi-centre, retrospective, observational study. Pre-emptive vitrectomy was performed in non-fibrotic diabetic eyes with a visual acuity (VA) of 20/50 or better, where there was extensive persistent neovascularisation despite prior panretinal photocoagulation, and where the fellow eye had established sight loss despite vitrectomy for tractional complications. The primary outcome measure was the VA at last visit. Results: Twenty patients were included. The mean age was 39 ± 14 years. Fifteen patients were Type 1 diabetic. The median baseline VA was 20/30 and remained stable at 20/28 at last visit (median follow-up period: 24 months). Eight eyes (40.0%) developed post-operative vitreous cavity haemorrhage; 4 of which required a vitreous cavity washout procedure. There were no post-operative retinal detachments. The index eye remained the significantly better eye at all time points bar one month post-surgery. Regression of retinopathy grading was observed in all eyes. Conclusion: In this pilot study, we found no sight loss with pre-emptive diabetic vitrectomy. Better eye status was maintained in this high-risk group. Further study with larger number of patients and longer-term follow-up is indicated.

Publication metadata

Author(s): Tan SZ, Steel DH, Stanzel BV, Bedersdorfer M, Szurman P, Saidkasimova S, Schielke KC, Kumaran N, Laidlaw DAH

Publication type: Article

Publication status: Published

Journal: Eye

Year: 2022

Volume: 37

Pages: 1553–1557

Online publication date: 21/07/2022

Acceptance date: 22/06/2022

ISSN (print): 0950-222X

ISSN (electronic): 1476-5454

Publisher: Springer Nature


DOI: 10.1038/s41433-022-02167-3


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