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Increased pre-alpha functional connectivity in dementia with Lewy bodies

Lookup NU author(s): Professor John-Paul TaylorORCiD

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Abstract

Background: Resting-state EEG studies have shown that neurodegenerative dementias like Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood. Objective: In the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity. Methods: Resting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands. Results: Statistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group. Conclusions: The results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.

Publication metadata

Author(s): D'Anselmo A, Prete G, Di Crosta A, Bristot L, Carrarini C, Jaramillo-Jimenez A, Palumbo R, Varanese S, Pilotto A, Pardini M, Arnaldi D, D'Antonio F, Ondracek D, Tinazzi M, Rektorova I, Kramberger M, Taylor J-P, Luzzi S, Bruno G, Babiloni C, Padovani A, Aarsland D, Mammarella N, Di Domenico A, Tommasi L, Bonanni L, on behalf of EDLB Consortium

Publication type: Article

Publication status: Published

Journal: Journal of Alzheimer's Disease

Year: 2025

Volume: 108

Issue: 3

Pages: 1132-1143

Print publication date: 01/12/2025

Online publication date: 09/10/2025

Acceptance date: 02/04/2018

ISSN (print): 1387-2877

ISSN (electronic): 1875-8908

Publisher: Sage Publications Ltd

URL: https://doi.org/10.1177/13872877251385424

DOI: 10.1177/13872877251385424

PubMed id: 41066217

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