ePrints

The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease

Lookup NU author(s): Dr Christopher Morris

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. Three studies have also shown an association of the tau locus with clinically diagnosed Parkinson's disease. Noting the significant incidence of clinical misdiagnosis of Parkinson's disease, we investigated this tau gene association in a series of 157 pathologically confirmed cases of brain stem Lewy body Parkinson's disease by analysing their tau haplotype status. Although H1H1 homozygotes are elevated in the Parkinson's disease cases (63.1%) compared to controls (56.1%) this difference is not significant (P = 0.22). These results indicate that any association must either be weak (with an odds ratio of less than 2) or that previous positive associations were due to contamination of clinically diagnosed cases with other diagnostic clinico-pathological entities such as neurofibrillary tangle Parkinson's syndrome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Morris CM; de Silva R; Hardy J; Crook J; Khan N; Graham EA; Wood NW; Lees AJ

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2002

Volume: 330

Issue: 2

Pages: 201-203

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/S0304-3940(02)00742-5

DOI: 10.1016/S0304-3940(02)00742-5

Altmetrics

Share