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Browsing publications by Professor Alastair Hawkins.

Newcastle AuthorsTitleYearFull text
Paul Thompson
Professor Alastair Hawkins
Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product2020
Paul Thompson
Professor Alastair Hawkins
Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme2019
Paul Thompson
Professor Alastair Hawkins
Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme2019
Dr Arnaud Basle
Dr Lorraine Hewitt
Dr Alan Koh
Dr Heather Lamb
Paul Thompson
et al.
Crystal structure of NucB, a biofilm-degrading endonuclease2018
Dr Nadia Rostami
Professor Alastair Hawkins
Dr Richard Holliday
Professor Philip Preshaw
Professor Nicholas Jakubovics
et al.
A Critical Role for Extracellular DNA in Dental Plaque Formation2017
Paul Thompson
Professor Alastair Hawkins
Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study2017
Dr David Wilkinson
Hua Lin
Sarah Charlton
Dr Adrian Falconer
Dr Craig Bullock
et al.
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: Molecular mechanisms and implications for extracellular matrix turnover2017
Paul Thompson
Professor Alastair Hawkins
Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme2016
Paul Thompson
Professor Alastair Hawkins
Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme2016
Paul Thompson
Professor Alastair Hawkins
Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme2016
Paul Thompson
Professor Alastair Hawkins
Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct2015