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Browsing publications by Dr Thomas Nicholls.

Newcastle AuthorsTitleYearFull text
Dr Mahmoud Fassad
Dr Katja Menger
Sila Hopton
Gavin Falkous
Professor Bobby McFarland
et al.
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability2023
Dr Thomas Nicholls
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion2022
Dr Katja Menger
Dr Thomas Nicholls
Professor Patrick Chinnery
The human mitochondrial genome contains a second light strand promoter2022
Dr Katja Menger
Dr James Chapman
Mushtaq Khazeem
Dr Dasha Deen
John Casement
et al.
Two type I topoisomerases maintain DNA topology in human mitochondria2022
Dr Katja Menger
Alejandro Rodriguez Luis
Dr James Chapman
Dr Thomas Nicholls
Controlling the topology of mammalianmitochondrial DNA2021
Dr Thomas Nicholls
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication2021
Dr Thomas Nicholls
Recurrent Horizontal Transfer Identifies Mitochondrial Positive Selection in a Transmissible Cancer2020
Dr James Chapman
Dr Yi Ng
Dr Thomas Nicholls
The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes.2020
Dr Thomas Nicholls
Dinucleotide degradation by REXO2 maintains promoter specificity in mammalian mitochondria2019
Dr Thomas Nicholls
Professor Patrick Chinnery
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila2019
Dr Diana Lehmann
Dr Helen Tuppen
Georgia Campbell
Charlotte Alston
Dr Conor Lawless
et al.
Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level2019
Dr Thomas Nicholls
Dr Jim Stewart
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria2018
Dr Thomas Nicholls
Separating and Segregating the Human Mitochondrial Genome2018
Dr Thomas Nicholls
Dr Ewen Sommerville
Professor Grainne Gorman
Emeritus Professor Doug Turnbull
Professor Patrick Chinnery
et al.
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA2018
Dr Thomas Nicholls
MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication2016
Dr Thomas Nicholls
Mitochondrial transcript maturation and its disorders2015
Dr Thomas Nicholls
Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease2015
Dr Thomas Nicholls
In D-loop: 40 years of mitochondrial 7S DNA2014
Dr Thomas Nicholls
Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease2014
Dr Joanna Rorbach
Dr Pierre Boesch
Dr Thomas Nicholls
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome2014