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Browsing publications by Professor Fiona Oakley.

Newcastle AuthorsTitleYearFull text
Professor Fiona Oakley
Reply2022
Lucy Gee
Professor Fiona Oakley
5-HT2B Receptors in Liver2021
Marina Barcena-Varela
Hannah Paish
Stuart Robinson
Jeremy French
Professor Fiona Oakley
et al.
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: Dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis2021
Professor Fiona Oakley
Interrogating mechanisms of liver fibrosis with omics2021
Marco Zaki
Dr Ahmed Mahdi
Dr Gillian Patman
Anna Whitehead
Joao Mauricio
et al.
Key features of the environment promoting liver cancer in the absence of cirrhosis2021
Dr Jack Leslie
Dr Emma Scott
Professor Quentin Anstee
Professor Fiona Oakley
Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma 2021
Dr Jack Leslie
Dr Marie-Helene Ruchaud
Amy Collins
Leena Habiballa
Dr Gabi Saretzki
et al.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner2021
Dr Jack Leslie
Stuart Robinson
Professor Fiona Oakley
Dr Saimir Luli
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging2021
Professor Fiona Oakley
Marco Zaki
Professor Derek Mann
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms2021
Anna Smith
Dr Julia Whitehall
Carla Bradshaw
Dr Fiona Robertson
Dr Alasdair Blain
et al.
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis2020
Edward Fielder
Dr Clare Tweedy
Dr Caroline Wilson
Professor Fiona Oakley
Dr Fiona LeBeau
et al.
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice2020
Dr Olivier Govaere
Dr Dina Tiniakos
Professor Quentin Anstee
Professor Fiona Oakley
Bone Morphogenic Protein 8B Promotes the Progression of Non-Alcoholic Steatohepatitis2020
Dr Julie Worrell
Dr Jack Leslie
Dr Graham Smith
Marco Zaki
Hannah Paish
et al.
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis2020
Dr Jack Leslie
Dr Marina Garcia Macia
Dr Saimir Luli
Dr Julie Worrell
William Reilly
et al.
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis2020
Dr Jack Leslie
Benjamin Millar
Alicia Del Carpio Pons
Rachel Burgoyne
Joseph Frost
et al.
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis2020
Professor Fiona Oakley
Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis2020
Dr Jack Leslie
Professor Fiona Oakley
Loss of ELK1 has differential effects on age-dependent organ fibrosis2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Professor Fiona Oakley
Dr Lee Borthwick
et al.
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse2020
Laura Sabater
Dr Luigi Locatelli
Professor Fiona Oakley
Dr Timothy Hardy
Jeremy French
et al.
RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat2020
Hannah Paish
Lee Reed
Helen Brown
Mark Bryan
Dr Olivier Govaere
et al.
A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices2019
Hannah Paish
Lee Reed
Abi Watson
Dr Jack Leslie
Professor Fiona Oakley
et al.
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease2019
Dr Dumitru Sirbu
Dr Saimir Luli
Dr Jack Leslie
Professor Fiona Oakley
Professor Andrew Benniston
et al.
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice using a Highly Bright Near-Infrared BODIPY Dye2019
Professor Fiona Oakley
Lucy Gee
Professor Neil Sheerin
Dr Lee Borthwick
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy2019
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Dr Dina Tiniakos
Professor Derek Mann
et al.
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage2019
Professor Fiona Oakley
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity2019
Clara Correia Melo
Dr Jodie Birch
Edward Fielder
Dr James Chapman
Dr Anthony Lagnado
et al.
Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice2019
Dr Sameh Abou-Beih
Dr Steven Masson
Professor Fiona Oakley
Dr Dina Tiniakos
Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome2019
Professor Fiona Oakley
Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway2018
Dr Mujdat Zeybel
Dr Saimir Luli
Laura Sabater
Dr Timothy Hardy
Professor Fiona Oakley
et al.
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A2017
Professor Fiona Oakley
Professor Derek Mann
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.2017
Dr Amy Fearn
Dr Aldi Situmorang
Christopher Fox
Professor Fiona Oakley
Rachel Howarth
et al.
The NF-kB1 is a key regulator of acute but not chronic renal injury2017
Dr Saimir Luli
Dr Stephen Hill
Helen Brown
Jack Leslie
Dr Helen Marshall
et al.
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo2016
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Dr Jack Leslie
Helene Sellier
et al.
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer2016
Dr Riem Gawish
Professor Fiona Oakley
Dr John Brain
B-cells and neutrophils promote disease tolerance to murine gram negative sepsis2016
Dr Sameh Abou-Beih
Dr Steven Masson
Professor Fiona Oakley
Dr Dina Tiniakos
Evaluation of centrilobular fibrosis in post-transplant liver: Preliminary results2016
Dr Marzena Ciechomska
Dr Steven O'Reilly
Professor Fiona Oakley
Professor Jaap van Laar
Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-22016
Christopher Fox
Dr Pasquale Cocchiaro
Professor Fiona Oakley
Rachel Howarth
Krystena Callaghan
et al.
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease2016
Dr Timothy Hardy
Professor Fiona Oakley
Professor Quentin Anstee
Professor Chris Day
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum2016
Dr Emma Fairhall
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system.2016
Stuart Robinson
Professor Derek Mann
Professor Derek Manas
Professor Fiona Oakley
Professor Jelena Mann
et al.
Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''2016
Dr Sameh Abou-Beih
Dr Steven Masson
Dr Beate Haugk
Professor Fiona Oakley
Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: Association with histological changes, hepatic stellate cell activation and impact on patient outcome2016
Professor Fiona Oakley
Dr Maria Perugorria
Professor Derek Mann
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury2016
Dr Phillip Probert
Dr Stephanie Meyer
Fouzeyyah Alsaeedi
Andrew Axon
Dr Emma Fairhall
et al.
An expandable donor-free supply of functional hepatocytes for toxicology2015
Professor Fiona Oakley
Professor Derek Mann
Chapter 15 - Stellate Cell Depletion Models2015
Dr Eva Moran Salvador
Dr Pier Paoli
Dr Graham Smith
Dr Agata Page
Rachel Howarth
et al.
MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis2015
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Professor Derek Mann
Professor Fiona Oakley
et al.
Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy2015
Dr Caroline Wilson
Dr Diana Jurk
Nicola Fullard
Paul Banks
Dr Agata Page
et al.
NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma2015
Dr Saimir Luli
Dr Daniela Di Paolo
Dr Caroline Wilson
Professor Matthew Wright
Helen Brown
et al.
Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice2015
Christopher Fox
Rachel Howarth
Krystena Callaghan
Dr Katrina Wood
Professor Fiona Oakley
et al.
Pepstatin A improves renal fibrosis by impairing UPA lysosomal recycling2015
Dr Luigi Locatelli
Dr Pier Paoli
Dr Timothy Hardy
Rachel Howarth
Professor Fiona Oakley
et al.
Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation2015
Aimen Amer
Dr Phillip Probert
Dr Michael Dunn
Margaret Knight
Dr Abigail Vallance
et al.
Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation2015
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Dr Dina Tiniakos
Professor Derek Mann
et al.
Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities2015
Dr Caroline Wilson
Dr Lindsay Murphy
Jack Leslie
Dr Stuart Kendrick
Jeremy French
et al.
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease2015
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Jelena Mann
Professor Alastair Burt
et al.
A reversible model for periportal fibrosis and a refined alternative to bile duct ligation2014
Dr Saimir Luli
Dr Stephen Hill
Professor Matthew Wright
Professor Derek Mann
Professor Fiona Oakley
et al.
A simple fluorescence based method to non-invasively image liver fibrosis2014
Dr Anna Moles Fernandez
Dr Lindsay Murphy
Dr Caroline Wilson
Dr Jayshree Bagchi Chakraborty
Christopher Fox
et al.
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells2014
Dr John Skamarauskas
Professor Fiona Oakley
Dr Fiona Smith
Carlo Bawn
Dr Michael Dunn
et al.
Non-invasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker2014
Dr Caroline Wilson
Professor Jelena Mann
Dr Meagan Walsh
Professor Fiona Oakley
Professor Matthew Wright
et al.
Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR32014
Dr Steven O'Reilly
Rachel Cant
Dr Marzena Ciechomska
Professor Fiona Oakley
Professor Sophie Hambleton
et al.
Serum Amyloid A (SAA) induces IL-6 in dermal fibroblasts via TLR2, IRAK4 and NF-κB2014
Dr Steven O'Reilly
Rachel Cant
Dr Marzena Ciechomska
James Finnigan
Professor Fiona Oakley
et al.
Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-kappa B2014
Dr Michelle Charles
Dr Karen Wallace
Dr Phillip Probert
Professor Fiona Oakley
Professor Matthew Wright
et al.
THE glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations2014
Dr Phillip Probert
Git Chung
Dr Simon Cockell
Professor Loranne Agius
Steven White
et al.
Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies2014
Dr Lindsay Murphy
Dr Jayshree Bagchi Chakraborty
Professor Jelena Mann
Professor Fiona Oakley
Professor Derek Mann
et al.
Deficient Neutrophil Recruitment into the Liver Parenchyma after an Acute CCl4 Challenge does not affect Fibrogenesis2013
Dr Lindsay Murphy
Dr Saimir Luli
Dr Lee Borthwick
Dr Steven O'Reilly
Professor Neil Perkins
et al.
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response2013
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
et al.
Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat2013
Dr Gillian Patman
Dr Despina Televantou
Anna Whitehead
Professor Chris Day
Professor Fiona Oakley
et al.
Mild Steatosis and Impaired Glucose Tolerance are Associated with Liver Cancer Development, While Progression to Nash Increases Number/Size in an Animal Model of NAFLD2013
Stuart Robinson
Professor Jelena Mann
Professor John Mathers
Professor Alastair Burt
Professor Fiona Oakley
et al.
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model2013
Professor Derek Mann
Professor Fiona Oakley
Serotonin paracrine signaling in tissue fibrosis2013
Dr Nicola Fullard
Dr Steven O'Reilly
Professor Jaap Van Laar
David Faini
Julie Diboll
et al.
The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice2013
Stuart Robinson
Professor Derek Mann
Professor Derek Manas
Professor Fiona Oakley
Professor Jelena Mann
et al.
The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome2013
Dr Maria Perugorria
Dr Lindsay Murphy
Dr Nicola Fullard
Dr Caroline Wilson
Professor Fiona Oakley
et al.
Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice2013
Professor Fiona Oakley
Professor Neil Perkins
BAG-1 interacts with the p50-p50 homodimeric NF-kappa B complex: implications for colorectal carcinogenesis2012
Dr Maria Perugorria
Dr Mujdat Zeybel
Mark Walsh
Shilu Amin
Professor Alastair Burt
et al.
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation2012
Professor Derek Mann
Professor Fiona Oakley
Inhibition of 536 phosphorylation site in NF-kappa B (RELA) reduces liver fibrosis in mouse progressive liver disease, but does not block the innate immune response2012
Dr Mujdat Zeybel
Dr Timothy Hardy
Frances Wong
Professor John Mathers
Christopher Fox
et al.
Multigenerational epigenetic adaptation of the hepatic wound-healing response2012
Dr Caroline Wilson
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
NF-kappa B1-/- suppresses ageing and carcinogen-induced hepatocellular carcinoma by limiting neutrophil accumulation and ROS production2012
Professor Fiona Oakley
Professor Derek Mann
Dr Neil Hanley
Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans2012
Dr Nicola Fullard
Professor Fiona Oakley
Roles of c-Rel signalling in inflammation and disease2012
Silvia Gaspar Pereira
Dr Nicola Fullard
Aidan Maxwell
Dr Lindsay Murphy
Dr Ralf Bauer
et al.
The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis2012
Dr Anna Moles Fernandez
Professor Fiona Oakley
Professor Derek Mann
A peptide mimetic of the functional SER536 phosphorylation site in NF-kappa B (RELA) inhibits liver fibrosis2011
Dr Maria Perugorria
Dr Caroline Wilson
Dr Mujdat Zeybel
Shilu Amin
Professor Fiona Oakley
et al.
Expression profiling of epigenetic regulators identifies ASH1 as a key activator of pro-fibrogenic genes2011
Dr Mujdat Zeybel
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
Professor Jelena Mann
et al.
Protective adaptation to liver fibrosis in a single generation by heritable epigenetic modifications2011
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Jelena Mann
Dr Maria Perugorria
et al.
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease2011
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Matthew Wright
Professor Derek Mann
Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell2011
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
TREM-2 expression is induced during the regeneration phase of liver injury and acts as a negative regulator of neutrophillic infiltration and hepatocyte proliferation2011
Dr Caroline Wilson
Professor Fiona Oakley
Professor Derek Mann
UCH-L1: A novel and functional marker for activated hepatic stellate cells2011
Andy Axon
Dr David Cowie
Professor Fiona Oakley
Professor Faith Williams
Professor Peter Blain
et al.
Acute oestradiol (E2) administration to mice results in liver portal tract inflammation2010
Professor Jelena Mann
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis2010
Professor Fiona Oakley
Professor Derek Mann
Dr Neil Hanley
Identification of SOX9 as a novel mechanism to explain aspects of liver fibrosis2010
Professor Jelena Mann
Aidan Maxwell
Professor Fiona Oakley
Professor Derek Mann
MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis2010
Dr Helen Marshall
Professor Fiona Oakley
Professor Matthew Wright
Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy2010
Professor Jelena Mann
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha2010
Professor Fiona Oakley
SOX9 is a critical regulator of extracellular matrix deposition during liver fibrosis2010
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Dr Mohammed Ebrahimkhani
et al.
The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation2010
Dr Ahmed Elsharkawy
Professor Fiona Oakley
Professor Derek Mann
Professor Jelena Mann
The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes2010
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation2010
Professor Fiona Oakley
Dr Martha Watson
Professor Derek Manas
Professor Derek Mann
Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis2009
Professor Jelena Mann
Xin Xu
Professor Fiona Oakley
Aidan Maxwell
Dr Ahmed Elsharkawy
et al.
Epigenetically Inherited Resistance to Liver Fibrosis2009
Dr Lindsay Murphy
Dr Mohammed Ebrahimkhani
Professor Derek Mann
Professor Fiona Oakley
Pharmacological Blockade of 5HT 2B Receptor Stimulates Liver Growth2009
Dr Roben Gieling
Vidya Rajasekaran
Dr Diana Jurk
Dr Ahmed Elsharkawy
Professor Alastair Burt
et al.
The Anti-Inflammatory and Anti-Proliferative Properties of the NFKB1 (P50) Gene Protect Against Hepatocellular Carcinoma2009
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Fiona Oakley
Professor Derek Mann
et al.
The NF-Kappa B Subunit C-Rel is Involved in Hepatocyte Proliferation in Chronic Injured and Regenerating Liver2009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Dr Ahmed Elsharkawy
Dr Roben Gieling
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
et al.
Attenuated inflammatory response in fibrotic livers of mice lacking the c-Rel subunit of NF-kB2008
Professor Fiona Oakley
Dr David Wilson
Professor Derek Mann
Dr Neil Hanley
Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis2008
Professor Fiona Oakley
Dr Ahmed Elsharkawy
Professor Derek Mann
Hepatic nuclear factor κB regulates neutrophil recruitment to the injured brain2008
Dr Roben Gieling
Dr Martha Watson
Professor Fiona Oakley
Professor Derek Mann
Highly specific inhibitors define a conserved function for NF-kB as a regulator of apoptosis in both human and rodent hepatic stellate cells2008
Professor Fiona Oakley
Professor Albert Geerts
Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells2008
Dr Martha Watson
Dr Karen Wallace
Dr Roben Gieling
Professor Derek Manas
Professor Derek Mann
et al.
NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts2008
Professor Fiona Oakley
Nuclear factor-κB1: Regulation and function2008
Professor Fiona Oakley
Professor Derek Mann
RelA serine 536 phosphorylation could be a biomarker for fibrosis that may be susceptible to regression following attenuatino of renin-angiotensin signaling2008
Dr Mohammed Ebrahimkhani
Professor Derek Mann
Professor Fiona Oakley
Serotonin 2B receptor: A novel negative regulator of liver growth2008
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Professor Fiona Oakley
et al.
The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice2008
Professor Fiona Oakley
Dr Martha Watson
Professor Derek Mann
The renin angiotensin system as an activator of NF-KB and a survival signal for rat and human hepatic myofibroblasts2008
Professor Jelena Mann
Professor Fiona Oakley
Dr Ahmed Elsharkawy
Professor Derek Mann
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis2007
Professor Fiona Oakley
Professor Derek Mann
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis2006
Professor Derek Mann
Professor Fiona Oakley
An explanation for the apparent cell-selectivity of sulfasalazine as an inducer of hepatic myofibroblast apoptosis2006
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation2006
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Derek Mann
Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats2006
Professor Derek Mann
Professor Fiona Oakley
Real-time in vivo analysis of NF-kappaB activation reveals a role for the liver as a regulator of acute brain inflammation2006
Peter Smith
Professor Fiona Oakley
Professor Derek Mann
Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging2005
Professor Fiona Oakley
Dr Carlyn Marek
Professor Matthew Wright
Professor Derek Mann
Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis2005
Professor Derek Mann
Professor Fiona Oakley
NF-kappaB: a signal for cancer2005
Professor Fiona Oakley
Professor Derek Mann
Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity2005
Professor Fiona Oakley
Professor Jelena Mann
Professor Simi Ali
Professor Derek Mann
Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury2005
Dr Ahmed Elsharkawy
Professor Fiona Oakley
Professor Derek Mann
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis2005
Professor Fiona Oakley
Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.72004
Professor Fiona Oakley
Professor Derek Mann
Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp12004
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch12003
Professor Fiona Oakley
Professor Derek Mann
Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis2003
Professor Jelena Mann
Professor Fiona Oakley
Professor Derek Mann
CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells REGULATION BY TRAF2, AP-1, NF-κB, AND CBF12002
Clare McCormick
Professor Fiona Oakley
Professor Derek Mann
High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors2002