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Browsing publications by Professor Neil Sheerin.

Newcastle AuthorsTitleYearFull text
Professor Neil Sheerin
Comparative efficacy of ravulizumab and eculizumab in the treatment of atypical hemolytic uremic syndrome: an indirect comparison using clinical trial data2022
Professor Neil Sheerin
A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function2021
Dr Emily Thompson
Chloe Connelly
Professor Simi Ali
Professor Neil Sheerin
Colin Wilson
et al.
Cell therapy during machine perfusion2021
Emily Thompson
Dr Avinash Sewpaul
Lucy Bates
Dr Sam Tingle
Dr Aldi Situmorang
et al.
MicroRNA antagonist therapy during normothermic machine perfusion of donor kidneys 2021
Nina Jordan
Dr Sam Tingle
Victoria Shuttleworth
Katie Cooke
Dr Rachael Redgrave
et al.
MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis2021
Dr Jehill Parikh
Professor Peter Thelwall
Professor Neil Sheerin
Motion correction of free-breathing magnetic resonance renography using model-driven registration2021
Dr Emily Thompson
Lucy Bates
Dr Ibrahim Ibrahim
Dr Avinash Sewpaul
Rodrigo Figueiredo
et al.
Novel delivery of cellular therapy to reduce ischaemia reperfusion injury in kidney transplantation2021
Dr Tom Altmann
Dr Stephen Owens
Dr Dipayan Mitra
Professor Neil Sheerin
Professor David Kavanagh
et al.
Complement Factor I deficiency: a potentially treatable cause of fulminant cerebral inflammation2020
Dr Jack Leslie
Dr Marina Garcia Macia
Dr Saimir Luli
Dr Julie Worrell
William Reilly
et al.
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis2020
Dr Sam Tingle
Dr Avinash Sewpaul
Lucy Bates
Dr Emily Thompson
Victoria Shuttleworth
et al.
Dual microRNA blockade increases expression of antioxidant protective proteins; implications for ischaemia reperfusion injury2020
Emily Glover
Dr Ally Speight
Dr Despina Televantou
Dr Stephanie Needham
Professor Neil Sheerin
et al.
Immunosuppression-induced clonal T-cell lymphoproliferative disease causing severe diarrhoea mimicking coeliac disease following renal transplantation: a case report2020
Professor Neil Sheerin
KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.2020
Dr Vicky Brocklebank
Dr Kate Smith-Jackson
Dr Patrick Walsh
Professor Kevin Marchbank
Professor Claire Harris
et al.
Long-term outcomes and response to treatment in DGKE nephropathy2020
Dr Ian Logan
Dr Charlie Tomson
Professor Neil Sheerin
Dr Tim Ellam
Obesity, Sex, Race, and Early Onset Hypertension: Implications for a Refined Investigation Strategy2020
Professor Neil Sheerin
Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation2020
Dr Gareth Parry
Professor John Dark
Professor Neil Sheerin
The Impact of Severe Acute Kidney Injury Requiring Renal Replacement Therapy on Survival and Renal Function of Heart Transplant Recipients – A UK Cohort Study2020
Dr Jamie Willows
Professor Neil Sheerin
The role of complement in kidney disease2020
Beatriz Martinez Burgo
Professor John Kirby
Professor Neil Sheerin
Professor Simi Ali
A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation2019
Lucy Bates
Professor Neil Sheerin
A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplantation2019
Dr Tracy Finch
Dr Gregory Maniatopoulos
Dr Chris Gibbins
Professor Neil Sheerin
Dr Suren Kanagasundaram
et al.
Acute kidney injury electronic alerts: mixed methods Normalization Process Theory evaluation of their implementation into secondary care in England2019
Dr Jamie Willows
Dr Ian Logan
Professor Neil Sheerin
Dr Charlie Tomson
Dr Tim Ellam
et al.
Changing Protein Permeability with Nephron Loss; Evidence for a Human Remnant Nephron Effect2019
Dr Mustafa Sevinc
Susan Stamp
David Talbot
Professor Neil Sheerin
Comparison of the outcome of kidney transplantation after pulsatile or continuous ex vivo hypothermic machine perfusion of kidneys donated after cardiac death: analysis of kidney pairs2019
Professor Neil Sheerin
Eculizumab Prevents Thrombotic Microangiopathy in Patients With Atypical Hemolytic Uremic Syndrome in a Long-Term Observational Study2019
Professor Neil Sheerin
Haemolytic uremic syndrome: diagnosis and management2019
Laura Ferreras
Dr Anna Moles Fernandez
Dr Aldi Situmorang
Imogen Wilson
Katie Cooke
et al.
Heparan sulfate in chronic kidney diseases: exploring the role of 3-O-sulfation2019
Professor Fiona Oakley
Lucy Gee
Professor Neil Sheerin
Dr Lee Borthwick
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy2019
Dr Aldi Situmorang
Professor Neil Sheerin
Ischaemia reperfusion injury: mechanisms of progression to chronic graft dysfunction2019
Professor Neil Sheerin
Outcomes in Patients with Atypical Hemolytic Uremic Syndrome Treated with Eculizumab in a Long-term Observational Study2019
Dr Lu Wang
Professor Andrew Fisher
Professor Neil Sheerin
Professor John Dark
Severe acute kidney injury after cardiac transplantation is a marker of poor early outcome and impacts on late renal function -- a UK cohort study2019
Dr Lu Wang
Dr Gareth Parry
Professor Neil Sheerin
Professor John Dark
The need for haemofiltration after lung transplantation is a marker of poor early outcomes, but has no deleterious long-term renal effect -- a UK cohort study2019
Emily Glover
Professor Neil Sheerin
Urinary tract infection2019
Dr Emma Montgomery
Professor Neil Sheerin
Glomerular filtration rate: new age- and gender- specific reference ranges and thresholds for living kidney donation2018
Professor Neil Sheerin
Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study2018
Emily Glover
Nina Jordan
Professor Neil Sheerin
Professor Simi Ali
Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction2018
Victoria Shuttleworth
Dr Luke Gaughan
Lotfia Nawafa
Professor Neil Sheerin
Dr Ian Logan
et al.
The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD32018
Catriona Barker
Sarah Thompson
Dr Graeme O'Boyle
Professor Neil Sheerin
Professor Simi Ali
et al.
CCL2 nitration is a negative regulator of chemokine-mediated inflammation2017
Dr Vicky Brocklebank
Dr Sally Johnson
Dr Patrick Walsh
Dr Edwin Wong
Dr Larissa Kerecuk
et al.
Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland2017
Dr Jennifer Duff
Professor Neil Sheerin
Professor John Sayer
Dr Gavin Hudson
Professor Patrick Chinnery
et al.
Mutations in mitochondrial DNA causing tubulointerstitial kidney disease2017
Professor Neil Sheerin
Outcomes of patients with atypical haemolytic uraemic syndrome with native and transplanted kidneys treated with eculizumab: a pooled post hoc analysis2017
Sarah Thompson
Beatriz Martinez Burgo
Professor John Kirby
Professor Neil Sheerin
Professor Simi Ali
et al.
Regulation of chemokine function: The roles of GAG-binding and post-translational nitration2017
Dr Amy Fearn
Dr Aldi Situmorang
Christopher Fox
Professor Fiona Oakley
Rachel Howarth
et al.
The NF-kB1 is a key regulator of acute but not chronic renal injury2017
Professor Neil Sheerin
Professor David Kavanagh
Professor Tim Goodship
Dr Sally Johnson
A national specialised service in England for atypical haemolytic uraemic syndrome – the first year’s experience2016
Dr Suren Kanagasundaram
Dr Andrew Sims
Dr David Price
Professor Neil Sheerin
Computerised clinical decision support for the early recognition and management of acute kidney injury: a qualitative evaluation of end-user experience2016
Susan Stamp
David Talbot
Professor Neil Sheerin
Ex Vivo Perfusion Characteristics of Donation After Cardiac Death Kidneys Predict Long-Term Graft Survival2016
Christopher Fox
Dr Pasquale Cocchiaro
Professor Fiona Oakley
Rachel Howarth
Krystena Callaghan
et al.
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease2016
Beatriz Martinez Burgo
Professor Simi Ali
Jennifer Kirby
Professor Neil Sheerin
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.2016
Professor Neil Sheerin
Long-Term follow-up study of Eculizumab for prevention of thrombotic microangiopathy in patients with atypical hemolytic uremic syndrome2016
Dr Pasquale Cocchiaro
Christopher Fox
Rachel Howarth
Dr Katrina Wood
Professor Neil Sheerin
et al.
Lysosomal Protease Cathepsin D, new player in apoptosis during acute kidney injury2016
Dr Pasquale Cocchiaro
Christopher Fox
Nicholas Tregidgo
Rachel Howarth
Dr Katrina Wood
et al.
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury2016
Professor Tim Goodship
Professor Neil Sheerin
Management of Recurrent aHUS After Adult Kidney transplantation Despite Eculizumab Prophylaxis.2016
Professor Neil Sheerin
Renal Outcome with Eculizumab in Patients with aHUS with Native and Transplanted Kidneys: Pooled Analysis of 100 Patients.2016
Dr Gus Brooks
Dr Aaron Liew
Dr Helen Marshall
Dr Ali Aldibbiat
Professor Neil Sheerin
et al.
De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes2015
Dr Isabel Pappworth
Dr Edwin Wong
Professor Neil Sheerin
Professor Kevin Marchbank
An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy2015
Professor Neil Sheerin
Behaviour of Transplanted Tumours and Role of Matching in Rejection2015
Amy Fearn
Professor Neil Sheerin
Complement activation in progressive renal disease2015
Professor Neil Sheerin
Eculizumab Prevents Thrombotic Microangiopathy: Long-Term Follow-up Study of Patients with Atypical Hemolytic Uremic Syndrome2015
Professor Tim Goodship
Professor Neil Sheerin
Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies2015
Professor Neil Sheerin
Dr Andrew Sims
Dr David Price
Dr Suren Kanagasundaram
Electronic Clinical Decision Support for the Early Recognition and Management of Acute Kidney Injury: Qualitative Evaluation of End-User Experience2015
Dr Andrew Sims
Professor Neil Sheerin
Dr David Price
Dr Suren Kanagasundaram
Electronic clinical decision support for the early recognition and management of acute kidney injury: quantitative evaluation of outcomes2015
Dr Mustafa Sevinc
Susan Stamp
Dr Noel Carter
Professor Neil Sheerin
David Talbot
et al.
Ex Vivo perfusion characteristics of DCD kidneys predict long-term graft survival2015
Dr Edwin Wong
Dr Jeremy Palmer
Professor Neil Sheerin
Dr Isabel Pappworth
FH1-5(18-20) ameliorates experimental C3 glomerulopathy; generation and testing of a murine version for further pre-clinical experiments2015
Dr Sarah McCloskey
Professor Neil Sheerin
From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions2015
Laura Ferreras
Professor Neil Sheerin
Professor John Kirby
Professor Simi Ali
Mechanisms of renal graft chronic injury and progression to interstitial fibrosis2015
Dr Faryal Afridi
Dr Rachael Coates
Professor Neil Sheerin
David Talbot
Outcomes of ABOi Renal Transplants: A single centre experience over a seven year period2015
Dr Edwin Wong
Rachel Challis
Professor Neil Sheerin
Dr Sally Johnson
Professor David Kavanagh
et al.
Patient stratification and therapy in atypical haemolytic uraemic syndrome (aHUS)2015
Christopher Fox
Rachel Howarth
Krystena Callaghan
Dr Katrina Wood
Professor Fiona Oakley
et al.
Pepstatin A improves renal fibrosis by impairing UPA lysosomal recycling2015
Dr Luca Ermini
Dr William Howell
Professor Neil Sheerin
Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome2015
Dr Ian Logan
Victoria Shuttleworth
Dr Luke Gaughan
Lotfia Nawafa
Professor Neil Sheerin
et al.
The Lysine Methyltransferase SETD7 is critical for TGF B-1 driven fibrosis2015
Professor Tim Goodship
Dr Alison Brown
Professor Neil Sheerin
Thrombotic microangiopathy as a cause of chronic kidney transplant dysfunction: a case report demonstrating successful treatment with Eculizumab2015
Dr Caroline Wilson
Dr Lindsay Murphy
Jack Leslie
Dr Stuart Kendrick
Jeremy French
et al.
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease2015
Professor Neil Sheerin
Urinary tract infection2015
Professor Neil Sheerin
Dr Judith Hall
Rob Pickard
E. coli inhibits innate immunity to facilitate pyelonephritic infections2014
Professor David Kavanagh
Professor Neil Sheerin
Management of hemolytic uremic syndrome2014
Dr James Frith
Professor Fai Ng
Professor Chris Day
Dr Brendan Payne
Professor Neil Sheerin
et al.
Orthostatic intolerance is common in chronic disease - A clinical cohort study2014
Professor Neil Sheerin
Prognosis and management of chronic kidney disease (CKD) at the end of life2014
Professor Neil Sheerin
Thrombotic microangiopathies2014
Dr Ian Logan
Professor Neil Sheerin
Anticoagulation and kidney injury: rare observation or common problem?2013
Professor Simi Ali
Professor Neil Sheerin
Biomarkers of acute injury: predicting the long-term outcome after transplantation2013
Professor Neil Sheerin
Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: background, rationale, and study protocol2013
Professor Tim Goodship
Professor Neil Sheerin
Efficacy of Eculizumab in atypical hemolytic uremic syndrome (aHUS) patients with or without prior transplant2013
Dr Edwin Wong
Mark Brady
Professor Neil Sheerin
Severe intestinal oedema due to nephrotic syndrome2013
Professor Neil Sheerin
Professor Tim Goodship
Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome2013
Dr Luca Ermini
Professor Tim Goodship
Dr Lisa Turnbull
Professor Heather Cordell
Dr Veronique Fremaux-Bacchi
et al.
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS.2012
Dr Luca Ermini
Dr Ian Wilson
Professor Tim Goodship
Professor Neil Sheerin
Complement polymorphisms: Geographical distribution and relevance to disease2012
Dr Valerie Wilson
Dr Iain Moore
Dr Lisa Turnbull
Professor Kevin Marchbank
Professor Neil Sheerin
et al.
Postpartum aHUS Secondary to a Genetic Abnormality in Factor H Acquired Through Liver Transplantation2012
Dr Eva-Maria Hunze
Professor Neil Sheerin
Professor Kevin Marchbank
Targeting the glomerular basement membrane to control unwanted complement activation2012
Dr Amy Fearn
Professor Neil Sheerin
Complement activation drives interstitial inflammation and fibrosis in models of kidney disease2011
Dr Luca Ermini
Professor Tim Goodship
Dr Lisa Turnbull
Professor Heather Cordell
Dr Veronique Fremaux-Bacchi
et al.
Genetic variants in CFH and CD46 are the major susceptibility factors for aHUS-An association study of multiple complement genes2011
Dr Ellen Hatch
Professor Louise Parker
Professor John Kirby
Professor Neil Sheerin
Infiltrating renal T cells are activated and respond to self antigen2011
Dr Alison Brown
Professor Tim Goodship
Professor Neil Sheerin
Professor Derek Manas
Successful Treatment of De Novo Posttransplant Thrombotic Microangiopathy With Eculizumab2011
Dr Amy Fearn
Dr Steven Lisgo
Dr Steven Darby
Professor Neil Sheerin
The influence of complement activation on chronic renal inflammation and fibrosis2011
Dr Amy Fearn
Dr Steven Lisgo
Dr Steven Darby
Professor Neil Sheerin
The influence of complement activation on chronic renal inflammation and fibrosis2011
Professor Neil Sheerin
Trajectories of Illness in Stage 5 Chronic Kidney Disease: A Longitudinal Study of Patient Symptoms and Concerns in the Last Year of Life2011
Professor Neil Sheerin
Endogenous Ligands for TLR2 and TLR4 Are Not Involved in Renal Injury following Ureteric Obstruction2010
Dr Amy Fearn
Professor Neil Sheerin
Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction2010
Dr Amy Fearn
Professor Neil Sheerin
The influence of complement activation on chronic renal inflammation and fibrosis2010
Professor Neil Sheerin
A Novel Role for Nephrin in the Maintenance of Glomerular Structure2009
Dr Ellen Hatch
Professor Neil Sheerin
C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy2009
Professor Neil Sheerin
Complement activation and progression of chronic kidney disease2009
Dr V Ingham
Professor Neil Sheerin
Diabetic glomerular disease: Pitfalls in diagnosis2009
Professor Julia Newton
Professor Neil Sheerin
Fatigue in early renal disease2009
Professor Neil Sheerin
Illness trajectories: an important concept in the management of kidney failure2009
Dr Amy Fearn
Professor Neil Sheerin
Role for CD4+ T cells in Renal Fibrosis2009
Professor Neil Sheerin
Synergy between type 1 fimbriae expression and C3 opsonisation increases internalisation of E-coli by human tubular epithelial cells2009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Professor Neil Sheerin
Understanding Symptoms in Patients with Advanced Chronic Kidney Disease Managed without Dialysis: Use of a Short Patient-Completed Assessment Tool2009
Professor Neil Sheerin
Dialysis or not? A comparative survival study of patients over 75 years of age with chronic kidney disease stage - Reply2008
Dr Daniela Lee
Professor Neil Sheerin
Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure2008
Professor Neil Sheerin
Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation2008
Professor Neil Sheerin
Reply2008
Professor Neil Sheerin
Should Complement Activation Be a Target for Therapy in Renal Transplantation?2008
Professor Neil Sheerin
Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury2008
Professor Neil Sheerin
The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli2008
Professor Neil Sheerin
Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 52007
Professor Neil Sheerin
Mechanisms of disease: the complement system in renal injury - new ways of looking at an old foe2007
Professor Neil Sheerin
Accumulation of Immune Complexes in Glomerular Disease Is Independent of Locally Synthesized C32006
Professor Neil Sheerin
CD46 (Membrane Cofactor Protein) Acts as a Human Epithelial Cell Receptor for Internalization of Opsonized Uropathogenic Escherichia coli2006
Professor Neil Sheerin
Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection2006
Professor Neil Sheerin
Influence of Donor C3 Allotype on Late Renal-Transplantation Outcome2006
Professor Neil Sheerin
Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products2006
Professor Neil Sheerin
Mycobacterium simiae: a previously undescribed pathogen in peritoneal dialysis peritonitis2005
Dr Muhammad Khan
Professor Neil Sheerin
Urinary tract infections: new insights into a common problem2005
Professor Neil Sheerin
Autoimmune renal injury in C3- and C4-deficient mice: a histological and functional study2004
Dr Zahed Chowdhury
Professor Neil Sheerin
Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection2004
Professor Neil Sheerin
The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells2004
Professor Neil Sheerin
Urinary tract infections: advances and new therapies2004
Professor Neil Sheerin
Positron emission tomography in a patient with renal malacoplakia2003
Professor Neil Sheerin
Leaked protein and interstitial damage in the kidney: is complement the missing link?2002
Professor Neil Sheerin
Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli2001
Professor Neil Sheerin
Late allograft loss due to recurrence of p-ANCA-associated systemic vasculitis in a patient with relapsing polychondritis2001
Professor Neil Sheerin
Protection and injury: the differing roles of complement in the development of glomerular injury2001
Professor Neil Sheerin
Spontaneous Abdominal Hemorrhage with AA-amyloidosis and Vasculitis in a Patient with Rheumatoid Arthritis2001
Professor Neil Sheerin
Successful medical treatment of acute bilateral emphysematous pyelonephritis2000
Professor Neil Sheerin
Michael Carroll
Altered distribution of intraglomerular immune complexes in C3-deficient mice1999
Professor Neil Sheerin
Apical Proteins Stimulate Complement Synthesis by Cultured Human Proximal Tubular Epithelial Cells1999
Professor Neil Sheerin
Chronic Interstitial Damage in Proteinuria. Does Complement Mediate Tubulointerstitial Injury?1999
Professor Neil Sheerin
Contribution of renal secreted complement C3 to the circulating pool in humans1999
Professor Neil Sheerin
In vitro erythrophagocytosis by renal tubular cells and tubular toxicity by haemoglobin and iron1999