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Browsing publications by Professor David Kavanagh.

Newcastle AuthorsTitleYearFull text
Professor David Kavanagh
Alternative Complement Pathway Inhibition With Iptacopan for the Treatment of C3 Glomerulopathy-Study Design of the APPEAR-C3G Trial2022
Emily Glover
Dr Kate Smith-Jackson
Dr Vicky Brocklebank
Vicky Wilson
Dr Patrick Walsh
et al.
Assessing the impact of prophylactic eculizumab on renal graft survival in atypical haemolytic uraemic syndrome2022
Professor David Kavanagh
Complement and the prothrombotic state2022
Dr Gemma Thompson
Professor David Kavanagh
Diagnosis and treatment of thrombotic microangiopathy2022
Professor Claire Harris
Professor David Kavanagh
Evaluating a causal relationship between Complement Factor I protein level and advanced age-related macular degeneration using Mendelian Randomisation2022
Dr Patrick Walsh
Professor David Kavanagh
None Fits All: Unraveling Structural Rearrangements of the CFH Gene Cluster in Atypical Hemolytic Uremic Syndrome Patients Using Molecular Combing and Long-Fragment Targeted Sequencing2022
Nik Tzoumas
Professor David Kavanagh
Professor Heather Cordell
Professor David Steel
Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank2022
Dr Sarah Dunn
Dr Vicky Brocklebank
Andrew Bryant
Dr Thomas Chadwick
Dr Sally Johnson
et al.
Saftey and impact of eculizumab withdrawal in patients with atypical haemolytic uraemic syndrome: protocol for a multicentre, open-label, prospective, single-arm study2022
Professor David Kavanagh
Use of a B-cell depleting regimen for antifactor H autoantibody-mediated membranoproliferative glomerulonephritis in a paediatric patient2022
Professor Kevin Marchbank
Dr Isabel Pappworth
Harriet Denton
Kate Cooke
Grant Richardson
et al.
C3 Glomerulopathy and Related Disorders in Children.2021
Dr Edwin Wong
Thomas Hallam
Dr Vicky Brocklebank
Dr Patrick Walsh
Dr Kate Smith-Jackson
et al.
Functional characterisation of rare genetic variants in the N-terminus of complement factor H in aHUS, C3G and AMD2021
Dr Ola Kamala
Dr Thomas Hallam
Tom Cox
Dr Yi Yang
Dr Falguni Vyas
et al.
Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice2021
Professor David Kavanagh
Interventions for atypical haemolytic uraemic syndrome.2021
Professor David Kavanagh
Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults2021
Professor David Steel
Professor David Kavanagh
Prevalence and phenotype associations of complement factor I mutations in geographic atrophy2021
Nik Tzoumas
Dr Dean Hallam
Professor Claire Harris
Professor Majlinda Lako
Professor David Kavanagh
et al.
Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.2021
Tom Hallam
Professor Claire Harris
Nik Tzoumas
David Steel
Victoria Shuttleworth
et al.
The Rare C9 P167S Risk Variant for Age-related Macular Degeneration Increases Polymerization of the Terminal Component of the Complement Cascade2021
Professor David Kavanagh
Cocaine-associated atypical haemolytic uraemic syndrome in a genetically susceptible individual2020
Dr Tom Altmann
Dr Stephen Owens
Dr Dipayan Mitra
Professor Neil Sheerin
Professor David Kavanagh
et al.
Complement Factor I deficiency: a potentially treatable cause of fulminant cerebral inflammation2020
Edvinas Cerniauskas
Dr Marzena Kurzawa-Akanbi
Dr Long Xie
Dr Dean Hallam
Marina Moya Molina
et al.
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function2020
Professor David Kavanagh
Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration2020
Dr Vicky Brocklebank
Dr Kate Smith-Jackson
Dr Patrick Walsh
Professor Kevin Marchbank
Professor Claire Harris
et al.
Long-term outcomes and response to treatment in DGKE nephropathy2020
Professor David Kavanagh
Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international multidisciplinary working group.2020
Dr Zohreh Nademi
Dr Alex Battersby
Dr Terence Flood
Dr Stephen Owens
Professor Andrew Cant
et al.
New Insights Into Risk Factors for Transplant-Associated Thrombotic Microangiopathy in Pediatric HSCT2020
Dr Sanj Ugrinovic
Professor David Kavanagh
Primary pneumococcal peritonitis can be the first presentation of a familial complement factor I deficiency2020
Tom Hallam
Professor Kevin Marchbank
Professor Claire Harris
Victoria Shuttleworth
Professor David Kavanagh
et al.
Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration2020
Professor David Kavanagh
The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment2020
Dr Veronique Fremaux-Bacchi
Professor David Kavanagh
C3 glomerulopathy — understanding a rare complement-driven renal disease2019
Dr Kate Smith-Jackson
Dr Yi Yang
Harriet Denton
Katie Cooke
Professor David Kavanagh
et al.
Hyper-functional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice 2019
Dr Christopher Duncan
Dr Benjamin Thompson
Dr Rui Chen
Dr Florian Gothe
Victoria Shuttleworth
et al.
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT22019
Dr Patrick Walsh
Professor David Kavanagh
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism2018
Professor Claire Harris
Professor David Kavanagh
Dr Ruyue Sun
Developments in anti-complement therapy; from disease to clinical trial2018
Dr Edwin Wong
Professor David Kavanagh
Diseases of complement dysregulation—an overview2018
Dr Patrick Walsh
Dr Sally Johnson
Dr Vicky Brocklebank
Dr Jacobo Salvatore
Professor David Kavanagh
et al.
Glucose-6-Phosphate Dehydrogenase Deficiency Mimicking Atypical Hemolytic Uremic Syndrome2018
Professor David Kavanagh
Introduction to complement in health and disease: novel aspects and insights.2018
Professor David Kavanagh
Dr Valerie Wilson
Professor Tim Goodship
Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy2018
Dr Vicky Brocklebank
Dr Katrina Wood
Professor David Kavanagh
Thrombotic microangiopathy and the kidney2018
Dr Dean Hallam
Dr Joseph Collin
Dr Sanja Bojic
Dr Valeria Chichagova
Dr Adriana Buskin
et al.
An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure2017
Dr Vicky Brocklebank
Professor David Kavanagh
Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea2017
Dr Edwin Wong
Dr Yi Yang
Professor Kevin Marchbank
Professor David Kavanagh
Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation2017
Dr Vicky Brocklebank
Dr Sally Johnson
Dr Patrick Walsh
Dr Edwin Wong
Dr Larissa Kerecuk
et al.
Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland2017
Professor David Kavanagh
Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation2017
Professor David Kavanagh
Dr Edwin Wong
Dr Vicky Brocklebank
Hemolytic Uremic Syndrome in Pregnancy and Post-Partum2017
Dr Katrina Wood
Dr Alison Brown
Professor David Kavanagh
Dr Vicky Brocklebank
Rare genetic variants in Shiga toxin–associated haemolytic uraemic syndrome: genetic analysis prior to transplantation is essential2017
Rachel Challis
Dr Edwin Wong
Dr Vicky Brocklebank
Dr Valerie Wilson
Professor Kevin Marchbank
et al.
Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease2017
Rachel Challis
Dr Edwin Wong
Dr Holly Anderson
Dr Valerie Wilson
Dr Vicky Brocklebank
et al.
A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H–Related 3 Gene in Atypical Hemolytic Uremic Syndrome2016
Professor Neil Sheerin
Professor David Kavanagh
Professor Tim Goodship
Dr Sally Johnson
A national specialised service in England for atypical haemolytic uraemic syndrome – the first year’s experience2016
Dr Valerie Wilson
Tom Cox
Dr Kate Smith-Jackson
Professor David Kavanagh
Professor Tim Goodship
et al.
Chromosomal rearrangement – a rare cause of complement factor I associated atypical haemolytic uraemic syndrome2016
Professor David Kavanagh
Dr Kate Smith-Jackson
Eculizumab in children with hemolytic uremic syndrome2016
Professor David Kavanagh
Role of factor H and effects of C-terminal mutations on control of human platelet/granulocyte aggregate formation2016
Dr Vicky Brocklebank
Dr Edwin Wong
Professor Kevin Marchbank
Professor Tim Goodship
Professor David Kavanagh
et al.
The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies2016
Professor David Kavanagh
Rachel Challis
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature2016
Dr Edwin Wong
Professor David Kavanagh
Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome2015
Dr Veronique Fremaux-Bacchi
Professor Tim Goodship
Professor David Kavanagh
Atypical aHUS: State of the art2015
Rachael Watson
Dr Karim Bennaceur
Catriona Barker
Professor David Kavanagh
Professor Tim Goodship
et al.
Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS)2015
Dr Edwin Wong
Dr Vicky Brocklebank
Professor Tim Goodship
Professor David Kavanagh
Dr Anna Richards
et al.
Characterisation of a C3 Mutation with Increased Resistance to Complement Regulation in an Individual with Recurrent C3GN in a Renel Transplant2015
Dr Edwin Wong
Rachel Challis
Professor Neil Sheerin
Dr Sally Johnson
Professor David Kavanagh
et al.
Patient stratification and therapy in atypical haemolytic uraemic syndrome (aHUS)2015
Dr Mustafa Sevinc
Dr Vicky Brocklebank
Professor Tim Goodship
Professor David Kavanagh
Plasma resistant atypical hemolytic uremic syndrome associated with a CFH mutation treated with eculizumab: A case report2015
Professor David Kavanagh
Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels2015
Professor David Kavanagh
Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum Factor I level2015
Professor David Kavanagh
Structural basis for sialic acid-mediated self-recognition by complement factor H2015
Professor David Kavanagh
Successful Treatment of Atypical Hus with Eculizumab in Emirati Child with Novel DGKE Gene Mutation2015
Dr Vicky Brocklebank
Dr Edwin Wong
Professor Tim Goodship
Professor David Kavanagh
Atypical haemolytic uraemic syndrome associated with a CD46 mutation triggered by Shigella flexneri2014
Catriona Barker
Professor David Kavanagh
Professor Tim Goodship
Dr Isabel Pappworth
Autoantibodies to CD59, CD55, CD46 and CD35 are not associated with aHUS2014
Dr Edwin Wong
Dr Holly Anderson
Rachel Challis
Dr Lisa Turnbull
Gladys -
et al.
Characterization of a Factor H Mutation That Perturbs the Alternative Pathway of Complement in a Family with Membranoproliferative GN2014
Professor David Kavanagh
Professor Neil Sheerin
Management of hemolytic uremic syndrome2014
Dr Vicky Brocklebank
Professor David Kavanagh
Protecting the kidney from complement: atypical haemolytic uraemic syndrome2014
Professor David Kavanagh
Thrombotic Microangiopathy Associated with Interferon Beta2014
Dr Edwin Wong
Professor David Kavanagh
Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration2014
Rachel Challis
Dr Holly Anderson
Dr Edwin Wong
Dr Lisa Turnbull
Professor Kevin Marchbank
et al.
Atypical haemolytic uraemic syndrome associated with a novel hybrid CFH/CFHR3 gene2013
Professor David Kavanagh
Professor Tim Goodship
Dr Anna Richards
Atypical hemolytic uremic syndrome2013
Dr Edwin Wong
Professor Tim Goodship
Professor David Kavanagh
Complement therapy in atypical haemolytic uraemic syndrome (aHUS)2013
Dr Lucy Holmes
Dr Lisa Turnbull
Dr Iain Moore
Professor Kevin Marchbank
Professor David Kavanagh
et al.
Determining the Population Frequency of the CFHR3/CFHR1 Deletion at 1q322013
Dr Holly Anderson
Professor David Kavanagh
Rare variants in CFI, C3 and C9 are associated with high risk of advancedage-related macular degeneration.2013
Professor David Kavanagh
Dr Lisa Turnbull
Professor Kevin Marchbank
Professor Claire Harris
Professor Tim Goodship
et al.
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome2012
Professor Tim Goodship
Dr Isabel Pappworth
Dr Iain Moore
Dr Eva-Maria Hunze
James Staniforth
et al.
Factor H autoantibodies in membranoproliferative glomerulonephritis2012
Professor David Kavanagh
Dr Isabel Pappworth
Christine Hayes
Dr Iain Moore
Dr Eva-Maria Hunze
et al.
Factor I Autoantibodies in Patients with Atypical Hemolytic Uremic Syndrome: Disease-Associated or an Epiphenomenon?2012
Dr Edwin Wong
Dr Holly Anderson
Rachel Challis
Professor Kevin Marchbank
Professor David Kavanagh
et al.
Familial membranoproliferative glomerulonephritis type I associated with a functionally significant mutation in complement factor H2012
Professor David Kavanagh
Marie Appleton
Professor Kim Bartlett
Interference of urinary amino acid analysis by pregabalin2012
Professor David Kavanagh
Dr Holly Anderson
Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome2012
Professor David Kavanagh
Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion2012
Professor David Kavanagh
Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H2011
Professor David Kavanagh
Professor Claire Harris
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities2011
Professor David Kavanagh
Professor Tim Goodship
Haemolytic Uraemic Syndrome2011
Professor David Kavanagh
Professor Tim Goodship
Dr Veronique Fremaux-Bacchi
Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort2011
Professor David Kavanagh
Structural basis for engagement by complement factor H of C3b on a self surface2011
Professor David Kavanagh
Dr Lisa Turnbull
Professor Kevin Marchbank
Professor Tim Goodship
A novel hybrid complement gene associated with familial haemolytic uraemic syndrome2010
Dr Iain Moore
Dr Lisa Turnbull
Dr Isabel Pappworth
Professor David Kavanagh
James Staniforth
et al.
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome2010
Professor David Kavanagh
Professor Tim Goodship
Atypical hemolytic uremic syndrome2010
Dr Isabel Pappworth
Dr Iain Moore
Dr Lisa Turnbull
Professor David Kavanagh
James Staniforth
et al.
Complement Factor H Autoantibodies and Age-Related Macular Degeneration2010
Dr Isabel Pappworth
Professor David Kavanagh
Dr Iain Moore
Dr Lisa Turnbull
Factor H autoantibodies are associated with MPGN2010
Professor David Kavanagh
Dr Isabel Pappworth
Dr John Tapson
Dr Iain Moore
Dr Lisa Turnbull
et al.
Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome2010
Professor David Kavanagh
Dr Lisa Turnbull
Professor Kevin Marchbank
Professor Tim Goodship
Functional characterisation of a novel hybrid complement factor H protein associated with atypical haemolytic uraemic2010
Professor David Kavanagh
Professor Tim Goodship
Genetics and complement in atypical HUS2010
Professor David Kavanagh
Professor Tim Goodship
Dr Veronique Fremaux-Bacchi
Mutations in complement regulatory proteins predispose to preeclampsia2010
Professor Tim Goodship
Professor David Kavanagh
Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy2010
Professor David Kavanagh
Professor Tim Goodship
Transplantation in Atypical Hemolytic Uremic Syndrome2010
Professor Kevin Marchbank
Professor David Kavanagh
Dr Lisa Turnbull
Professor Tim Goodship
Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1)2010
Professor Kevin Marchbank
Dr Lisa Turnbull
Dr Veronique Fremaux-Bacchi
James Staniforth
Professor David Kavanagh
et al.
Genomic disorders associated with aHUS2009
Dr Anna Richards
Professor David Kavanagh
Pathogenesis of thrombotic microangiopathy: insights from animal models2009
Professor David Kavanagh
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome2009
James Staniforth
Professor David Kavanagh
Dr Lisa Turnbull
Professor Tim Goodship
Professor Kevin Marchbank
et al.
Towards a highly specific Factor H ELISA for rapid screening of patient sera2009
Professor David Kavanagh
A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H2008
Dr Matthew Edey
Professor David Kavanagh
Dr Anne Lampe
Professor Judith Goodship
Dr Lisa Turnbull
et al.
A Novel Non-Synonymous Polymorphism (p.Arg240His) in C4b-Binding Protein Is Associated with Atypical Hemolytic Uremic Syndrome and Leads to Impaired Alternative Pathway Cofactor Activity2008
Professor David Kavanagh
Advances in understanding of pathogenesis of aHUS and HELLP2008
Professor David Kavanagh
Dr Anna Richards
Complement regulatory genes and hemolytic uremic syndromes2008
Professor David Kavanagh
New roles for the major human 3′-5′ exonuclease TREX1 in human disease2008
Professor David Kavanagh
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations2008
Professor David Kavanagh
Dr Matthew Edey
Dr Lisa Turnbull
Professor Judith Goodship
Dr Anne Lampe
et al.
A non-synonymous polymorphism (arg240his) in C4b-binding protein is associated with atypical haemolytic uraemic syndrome and leads to impaired alternative pathway cofactor activity2007
Professor David Kavanagh
C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy2007
Professor David Kavanagh
Dr Veronique Fremaux-Bacchi
Professor Tim Goodship
Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome2007
Professor David Kavanagh
Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneration2007
Professor David Kavanagh
Dr Veronique Fremaux-Bacchi
Professor Tim Goodship
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome2007
Professor David Kavanagh
Rachel Burgess
Professor Judith Goodship
Professor Tim Goodship
The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation2007
Professor David Kavanagh
Professor Tim Goodship
Update on evaluating complement in hemolytic uremic syndrome2007
Professor David Kavanagh
Professor Tim Goodship
Dr Anna Richards
Atypical haemolytic uraemic syndrome2006
Professor David Kavanagh
Dr Anna Richards
Rachel Burgess
Professor Judith Goodship
Professor Tim Goodship
et al.
Does complement factor B have a role in the pathogenesis of atypical HUS?2006
Professor David Kavanagh
Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications2006
Dr Veronique Fremaux-Bacchi
Professor David Kavanagh
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome2006
Professor David Kavanagh
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome2006
Professor David Kavanagh
Professor Tim Goodship
Membrane cofactor protein and factor I: Mutations and transplantation2006
Professor Geoff Toms
Professor David Kavanagh
Acute respiratory infection in a renal transplant recipient2005
Professor David Kavanagh
Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue2005
Professor David Kavanagh
Dr Liz Kemp
Professor Judith Goodship
Professor Tim Goodship
Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome2005
Professor David Kavanagh
Risk factors for restless legs syndrome in dialysis patients2005
Professor David Kavanagh
Peritoneal dialysis-associated peritonitis in Scotland (1999-2002)2004
Professor David Kavanagh
Restless legs syndrome in patients on dialysis2004
Professor David Kavanagh
The influence of pre-operative electrocardiographic abnormalities and cardiovascular risk factors on patient and graft survival following renal transplantation2002
Professor David Kavanagh
Electrocardiogram and Outcome following Renal Transplantation1999