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Browsing publications by Emeritus Professor Drew Rowan.

Newcastle AuthorsTitleYearFull text
Dr David Wilkinson
Dr Adrian Falconer
Hua Lin
Kat Cheung
Sarah Charlton
et al.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.2021
Dr Adrian Falconer
Dr Chun Chan
Dr Joseph Gray
Emeritus Professor Drew Rowan
Dr David Wilkinson
et al.
Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover2019
Dr Florian Gothe
Emeritus Professor Drew Rowan
Angela Grainger
Professor Andrew Cant
Dr Mary Slatter
et al.
Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib2019
David Hodgson
Emeritus Professor Drew Rowan
Dr Carole Proctor
Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli2019
Chris Macdonald
Dr Adrian Falconer
Dr Chun Chan
Dr David Wilkinson
Andrew Skelton
et al.
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes2018
Jonathan Baker
Adrian Falconer
Dr David Wilkinson
Emeritus Professor Nick Europe-Finner
Dr Gary Litherland
et al.
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes2018
Dr David Wilkinson
Dr Maria Arques Mengual
Emeritus Professor Drew Rowan
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: Implications for therapeutics2018
Dr David Wilkinson
Andrew Skelton
Emeritus Professor Nick Europe-Finner
Emeritus Professor Drew Rowan
Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.2017
Dr David Wilkinson
Angie Habgood
Dr Heather Lamb
Paul Thompson
Professor Alastair Hawkins
et al.
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms2017
Dr David Wilkinson
Hua Lin
Sarah Charlton
Dr Adrian Falconer
Dr Craig Bullock
et al.
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: Molecular mechanisms and implications for extracellular matrix turnover2017
Dr Rachel Williams
Andrew Skelton
Dr Stephen Todryk
Emeritus Professor Drew Rowan
Professor Philip Preshaw
et al.
Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts2016
Emeritus Professor Drew Rowan
Professor Iain McInnes
Dr Carl Goodyear
Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology2016
Dr Katherine Crossland
Dr Chun Chan
Tariq AlShehri
Dr Mario Abinun
Professor Andrew Gennery
et al.
Gain-of-function STAT1 mutations impair STAT3 activity in patients with Chronic Mucocutaneous Candidiasis (CMC)2015
Dr Dimitra Tsompani
Dr Matthew Barter
Emeritus Professor Drew Rowan
Professor David Young
The role of Histone Deacetylase 3 in chondrogenesis and osteoarthritis2015
Emeritus Professor Drew Rowan
Dr Gary Litherland
Tribbles and arthritis: what are the links?2015
Dr Carole Proctor
Christopher Macdonald
Dr Jenny Milner
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
A computer simulation approach for assessing therapeutic intervention points to prevent cytokine-induced cartilage breakdown2014
Dr Marzena Ciechomska
Dr Caroline Wilson
Achilleas FLOUDAS
Emeritus Professor Drew Rowan
Professor John Robinson
et al.
Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation2014
Emeritus Professor Drew Rowan
Dr Carl Goodyear
Bone changes preceed cartilage degradation in experimental osteoarthritis2014
Emeritus Professor Drew Rowan
Ruth Wyllie
Emerita Professor Helen Foster
Chronic arthritis in children and young people2014
Dr Katherine Crossland
Dr Mario Abinun
Professor Andrew Gennery
Professor Jelena Mann
Dr Dennis Lendrem
et al.
Gain-of-function stat1 mutation impairs stat3 function predisposing to chronic mucocutaneous candidiasis2014
Dr Gary Litherland
Martina Elias
Dr David Wilkinson
Sharon Watson
Professor David Young
et al.
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis2014
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Dr Carole Proctor
Investigating molecular mechanisms of ageing cartilage using computer simulation models2014
Professor David Young
Emeritus Professor Drew Rowan
Xin Xu
Emeritus Professor Tim Cawston
Dr Carole Proctor
et al.
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage2014
Dr Marta Radwan
Dr David Wilkinson
Dr Auriane Destrument
Sarah Charlton
Dr Matthew Barter
et al.
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination2014
Emeritus Professor Tim Cawston
Professor David Young
Emeritus Professor Drew Rowan
Tissue destruction and repair2014
Dr Carole Proctor
Christopher Macdonald
Dr Jenny Milner
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
A computer simulation approach for testing possible interventions to ameliorate collagen release2013
Dr Matthew Barter
Dr Auriane Destrument
Jenny Scott
Emeritus Professor Drew Rowan
Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation2013
Rachel Williams
Emeritus Professor Drew Rowan
Professor Philip Preshaw
Dr John Taylor
Leptin regulation of matrix metalloproteinase expression in human gingival fibroblasts2013
Emeritus Professor Drew Rowan
Macrophage Migration and Invasion Is Regulated by MMP10 Expression2013
Dr Marta Radwan
Christos Gavriilidis
Professor John Robinson
Emeritus Professor Drew Rowan
Professor David Young
et al.
Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes2013
Jonathan Baker
Dr Gary Litherland
Emeritus Professor Drew Rowan
The Role of Protein Kinase D Signalling in the Induction of Matric Metalloproteinases in Human Articular Chondrocytes2013
Dr Catherine Bui
Dr Matthew Barter
Jenny Scott
Martin Galler
Dr Louise Reynard
et al.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis2012
Yaobo Xu
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
et al.
Comparison of osteoarthritis and normal hip cartilage transcriptomes using RNA-seq reveals new candidate gene targets and associated pathways2012
Jie Zheng
Emeritus Professor Drew Rowan
Professor Andrew Gennery
Dr Mario Abinun
Dr Desa Lilic
et al.
Gain-of-function STAT1 mutations alter STAT3 activation in patients with chronic mucocutaneous candidiasis2012
Dr Gary Litherland
Martina Elias
Hannah Curtis
Emeritus Professor Drew Rowan
Glycogen synthase kinase-3 as a gatekeeper of human cartilage degradation2012
Christopher Macdonald
Emeritus Professor Drew Rowan
Emeritus Professor Nick Europe-Finner
Identification of synergistic transcriptional regulation for collagenase gene expression in chondrocytes2012
Yaobo Xu
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
et al.
Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA2012
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
Dr Mauro Santibanez Koref
et al.
Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA2012
Rachel Williams
Emeritus Professor Drew Rowan
Professor Philip Preshaw
Dr John Taylor
Interleukin-1 and leptin synergistically enhance matrix metallo-proteinase expression in human gingival fibroblasts2012
Dr Marta Radwan
Emeritus Professor Drew Rowan
Professor John Robinson
Emeritus Professor Tim Cawston
Professor David Young
et al.
Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression2012
Dr Gary Litherland
Madona Elias
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Professor David Young
et al.
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases2012
Dr Iain Goff
Emeritus Professor Drew Rowan
Dr Belinda Bateman
Emerita Professor Helen Foster
Poor sensitivity of musculoskeletal history in children2012
Dr Marzena Ciechomska
Dr Caroline Wilson
Emeritus Professor Drew Rowan
Professor John Robinson
Dr Andrew Knight
et al.
Antigen-specific B cells can acquire and present the rheumatoid arthritis candidate autoantigen aggrecan from a non-internalisable surface2011
Jie Zheng
Emeritus Professor Drew Rowan
Dr Desa Lilic
Effect of cytokine-induced STAT1 signaling on STAT3 activation and binding2011
Dr Marta Radwan
Emeritus Professor Drew Rowan
Professor John Robinson
Emeritus Professor Tim Cawston
Professor David Young
et al.
Pattern recognition receptors in osteoarthritic cartilage2011
Emeritus Professor Tim Cawston
Dr Rachel Lakey
Emeritus Professor Drew Rowan
Assay of matrix metalloproteinases against matrix substrates2010
Dr Marzena Ciechomska
Dr Caroline Wilson
Emeritus Professor Drew Rowan
Professor John Robinson
Dr Andrew Knight
et al.
Examination of the ability of autoreactive B cells to acquire and present the rheumatoid arthritis candidate autoantigen, aggrecan, from a non-internalizable surface2010
Dr Matthew Barter
Leon Pybus
Dr Gary Litherland
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes2010
Dr Hui Wang
Emeritus Professor Tim Cawston
Dr Gary Litherland
Madona Elias
Emeritus Professor Drew Rowan
et al.
Leptin produced by joint white adipose tissue induces cartilage degradation by up-regulation and activation of matrix metalloproteinases2010
Emeritus Professor Drew Rowan
Lipopolysaccharide modulates matrix metalloproteinase expression and cell migration in bone marrow-derived macrophages2010
Dr Gary Litherland
Dr Matthew Jefferson
Dr Matthew Barter
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix resorptionm in osteoarthritis2010
Emeritus Professor Drew Rowan
Overexpression of Oncostatin-M in lungs induces eotaxin-2 and eosinophil accumulation in C57BL/6 but not Balb/C mice in vivo2010
Dr Gary Litherland
Martina Elias
Dr Jonathan Catterall
Dr Matthew Barter
Matthew Farren
et al.
Protein Kinase C Isoforms ζ and Ɩ Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction2010
Dr Rachel Lakey
Emeritus Professor Drew Rowan
Professor John Isaacs
Emeritus Professor Tim Cawston
Dr Catharien Hilkens
et al.
A novel paradigm for dendritic cells as effectors of cartilage destruction2009
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Lithium inhibits cartilage degradation and MMP production induced by pro-inflammatory cytokines2009
Emeritus Professor Drew Rowan
Differential responses to oncostatin-M in C57BL/6 and BALB/C mice in vivo2008
Dr Gary Litherland
Dr Matthew Barter
Emeritus Professor Tim Cawston
Professor John Robinson
Emeritus Professor Drew Rowan
et al.
Differential Toll-like receptor-dependent collagenase expression in chondrocytes2008
Dr Jenny Milner
Amit Patel
Emeritus Professor Drew Rowan
Emerging Roles of Serine Proteinases in Tissue Turnover in Arthritis2008
Emeritus Professor Drew Rowan
Dr Gary Litherland
Dr Jenny Milner
Metalloproteases as potential therapeutic targets in arthritis treatment2008
Dr Matthew Jefferson
Emeritus Professor Drew Rowan
STATs and c-fos are critical for synergistic MMP-1 induction in chondrocytes2008
Dr Gary Litherland
Dr Craig Dixon
Dr Rachel Lakey
Tim Robson
David Jones
et al.
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent2008
Dr Heather Bigg
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Activity of matrix metalloproteinase-9 against native collagen types I and III2007
Emeritus Professor Drew Rowan
Professor David Young
Collagenase gene regulation by pro-inflammatory cytokines in cartilage2007
Dr Nicholas Peake
Emerita Professor Helen Foster
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography2006
Dr Jonathan Catterall
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M2006
Dr Jenny Milner
Professor David Young
David Jones
Dr Emma Barksby
Dr Angela Patterson
et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis2006
Dr Jenny Milner
Professor David Jones
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis2006
Dr Jenny Milner
Professor David Young
David Jones
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Fibroblast-activation protein-alpha is expressed by chondrocytes following a proinflammatory stimulus and is elevated in osteoarthritis2006
Emeritus Professor Drew Rowan
Professor David Deehan
Emeritus Professor Tim Cawston
Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases2006
Dr Emma Barksby
Ilka Wappler
Dr Heiko Peters
Dr Jenny Milner
Emeritus Professor Tim Cawston
et al.
Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes - Implications for cartilage destruction and repair2006
Dr Nicholas Peake
Dr Andrea Myers
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Emerita Professor Helen Foster
et al.
Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor2006
Dr Emma Barksby
Dr Jenny Milner
Dr Angela Patterson
Dr Nicholas Peake
Tim Robson
et al.
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis2006
Dr Jenny Milner
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Professor David Young
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis2006
Dr William Shingleton
Debra Jones
Xin Xu
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes2006
Dr Heather Bigg
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation2006
Dr Nicholas Peake
Emeritus Professor Drew Rowan
Dr Andrea Myers
Emeritus Professor Tim Cawston
Emerita Professor Helen Foster
et al.
Assessment of the clinical significance of MMP activity in juvenile idiopathic arthritis (JIA)2005
Dr Nicholas Peake
Emeritus Professor Drew Rowan
Dr Andrea Myers
Emeritus Professor Tim Cawston
Assessment of the clinical significance of MMPs in Juvenile Idiopathic Arthritis2005
Katie Lowes
Dr Alexei von Delwig
Emeritus Professor Drew Rowan
Professor John Robinson
CD4 T cells cross-react between several arthritogenic epitopes of aggrecan in BALB/c mice2005
Dr Steven Young-Min
Dr David Coady
Sarah Charlton
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Early rheumatoid arthritis patients with DR4 shared epitope alleles progress radiologically and have elevated levels of serum MMP-3, serum comp, urinary GLC-GAL-PYD and urinary collagen crosslinks2005
Tina Xu
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Evaluation of chondrocyte micromass culture for the study of cartilage degradation2005
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor α by the release of collagen fragments via collagenases2005
Dr Nicholas Peake
Dr Andrea Myers
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Emerita Professor Helen Foster
et al.
IL-6 and the soluble receptor in paired juvenile idiopathic arthritis (JIA) serum and SF samples2005
Dr Nicholas Peake
Dr Andrea Myers
Debra Jones
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study2005
Emeritus Professor Tim Cawston
Dr Heather Bigg
Dr Jenny Milner
Dr Jonathan Catterall
Dr Emma Barksby
et al.
Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases2005
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
OM in combination with TNFalpha induces a chondrocyte membrane associated aggrecanase2005
Dr Emma Barksby
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or-22005
Katie Lowes
Dr Alexei von Delwig
Professor Judith Goodship
Emeritus Professor Drew Rowan
Professor John Robinson
et al.
Specificity of CD4 T cell responses to aggrecan in BALB/c and DR1 transgenic mice2005
Katie Lowes
Dr Alexei von Delwig
Emeritus Professor Drew Rowan
Professor John Robinson
Specificity of CD4 T-cell responses to aggrecan in BALB/c and DR1 transgenic mice2005
Dr Steven Young-Min
Emeritus Professor Drew Rowan
Sarah Charlton
Dr David Coady
Emeritus Professor Tim Cawston
et al.
The biallelic 1G/2G single nucleotide polymorphism at position-1607BP of the MMP-1 promoter is not associated with rheumatoid arthritis, does not significantly affect measured levels of serum MMP-1 and is not associated with increased radiographic destruction2005
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL2004
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model2003
Emeritus Professor Tim Cawston
Dr Jenny Milner
Dr Jonathan Catterall
Emeritus Professor Drew Rowan
Cytokine synergy, collagenases and cartilage collagen breakdown2003
Emeritus Professor Tim Cawston
Dr Jenny Milner
Dr Jonathan Catterall
Emeritus Professor Drew Rowan
Cytokine synergy, collagenases and cartilage collagen breakdown2003
Dr Jenny Milner
Emeritus Professor Drew Rowan
Dr Sarah Elliott
Emeritus Professor Tim Cawston
Inhibition of furin-like enzymes blocks interleukin-1 alpha/oncostatin M-stimulated cartilage degradation2003
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo2003
Emeritus Professor Tim Cawston
Dr Hui Wang
Dr Christopher Richards
Emeritus Professor Drew Rowan
Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction2003
Professor David Young
Emeritus Professor Drew Rowan
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β12003
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage2003
Dr Bijayeswar Vaidya
Professor Simon Pearce
Stephen Charlton
Emeritus Professor Drew Rowan
Professor Pat Kendall-Taylor
et al.
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies2002
Dr Bijayeswar Vaidya
Professor Simon Pearce
Sarah Charlton
Nicola Marshall
Emeritus Professor Drew Rowan
et al.
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies2002
Professor Christopher Ward
Dr Gary Pritchard
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Emeritus Professor Nick Europe-Finner
et al.
Co-localisation of MMP-9 with neutrophils in stable lung transplant recipients - A potential role in Bronchiolitis Obliterans2002
Professor David Young
Emeritus Professor Drew Rowan
Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors2002
Paul Koshy
Neil Henderson
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines2002
Paul Koshy
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M - A time-course study using real-time quantitative reverse transcription-polymerase chain reaction2002
Emeritus Professor Tim Cawston
Paul Koshy
Emeritus Professor Drew Rowan
Assays of matrix metalloproteinases against matrix substrates2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Insulin-like growth factor-1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with interleukin-12001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Interleukin-13 blocks the release of collagen fragments from bovine nasal cartilage treated with proinflammatory cytokines by preventing pro-collagenase activation2001
Emeritus Professor Tim Cawston
Dr Severine Carrere
Dr Jonathan Catterall
Dr Richard Duggleby
Suzanne Elliott
et al.
Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronc pulmonary disease2001
Emeritus Professor Tim Cawston
Dr Severine Carrere
Dr Jonathan Catterall
Dr Richard Duggleby
Suzanne Elliott
et al.
Matrix metalloproteinases and TIMPs: Properties and implications for the treatment of chronic obstructive pulmonary disease2001
Emeritus Professor Tim Cawston
Dr Severine Carrere
Dr Jonathan Catterall
Dr Richard Duggleby
Suzanne Elliott
et al.
Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta 1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by transforming growth factor-beta 1 and insulin-like growth factor-1 in primary chondrocytes stimulated with tumour necrosis factor-alpha.2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Oncostatin M in combination with TNF synergistically induces expression and production of matrix metaollproteinases and promotes cartlilage breakdown.2001
Emeritus Professor Drew Rowan
Paul Koshy
Dr William Shingleton
Dr Beverley Degnan
Emeritus Professor Tim Cawston
et al.
Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown2001
Dr Jonathan Catterall
Dr Severine Carrere
Paul Koshy
Dr Beverley Degnan
Dr William Shingleton
et al.
Synergistic induction of matrix metalloproteinase 1 by interleukin-1 alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism2001
Dr Jonathan Catterall
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Synergistic regulation of chondrocytes by IL-1 and oncostatin M (OSM) involves interaction of JAK/STAT, MAPKinase and c-jun activation2001
Dr Heather Bigg
Emeritus Professor Drew Rowan
The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis2001
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Cartilage destruction in arthritis: Collagen and aggrecan-degrading proteinases2000
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Cartilage destruction in Arthritis: Collagen and Aggrecan-degrading Proteins2000
Dr Heather Bigg
Emeritus Professor Drew Rowan
Professor Derek Mann
Emeritus Professor Tim Cawston
Regulation of human TIMP-1 Gene Expression2000
Dr William Shingleton
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown2000
Dr William Shingleton
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and-13 are involved in cartilage collagen breakdown2000
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Transforming growth factor-beta 1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with IL-1 alpha2000
Paul Koshy
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
96-well plate assays for measuring collagenase activity using 3H-acetylated collagen1999
Emeritus Professor Drew Rowan
Dr Eugene Healy
Somatic mutations in the Peutz-Jegners (LKB1/STKII) gene in sporadic malignant melanomas1999
Emeritus Professor Tim Cawston
Paul Koshy
Emeritus Professor Drew Rowan
The regulation of MMPs and TIMPs in cartilage turnover1999
Emeritus Professor Tim Cawston
Paul Koshy
Emeritus Professor Drew Rowan
The regulation of MMPs and TIMPs in cartilage turnover1999
Emeritus Professor Tim Cawston
Paul Koshy
Emeritus Professor Drew Rowan
The regulation of MMPs and TIMPs in cartilage turnover1999
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Prevention of cartilage breakdown by matrix metalloproteinase inhibition - A realistic therapeutic target?1998
Emeritus Professor Tim Cawston
Paul Koshy
Emeritus Professor Drew Rowan
Dr William Shingleton
The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint1998
Emeritus Professor Drew Rowan
Professor Derek Mann
Emeritus Professor Tim Cawston
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 11997