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Browsing publications by Dr Heather Lamb.

Newcastle AuthorsTitleYearFull text
Dr Arnaud Basle
Dr Lorraine Hewitt
Dr Alan Koh
Dr Heather Lamb
Paul Thompson
et al.
Crystal structure of NucB, a biofilm-degrading endonuclease2018
Dr David Wilkinson
Angie Habgood
Dr Heather Lamb
Paul Thompson
Professor Alastair Hawkins
et al.
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms2017
Dr Heather Lamb
Professor Alastair Hawkins
Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases2014
Dr Heather Lamb
Paul Thompson
Professor Alastair Hawkins
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex2013
Shaun Martin
Dr Heather Lamb
Paul Thompson
Professor Penny Lovat
Professor Alastair Hawkins
et al.
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP782013
Dr Heather Lamb
Professor Alastair Hawkins
Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids2013
Dr Heather Lamb
Professor Alastair Hawkins
Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE12012
Dr Heather Lamb
Professor Alastair Hawkins
A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors2011
Dr Heather Lamb
Professor Alastair Hawkins
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM43512011
Dr Heather Lamb
Professor Alastair Hawkins
Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase2011
Dr Heather Lamb
Professor Alastair Hawkins
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase2010
Elaine Zhao
Samantha Hume
Dr Christopher Johnson
Paul Thompson
Dr Jun-yong Huang
et al.
The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases2010
Dr Heather Lamb
Professor Alastair Hawkins
Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids2010
Dr Heather Lamb
Professor Alastair Hawkins
2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase2009
Dr Heather Lamb
Professor Alastair Hawkins
Competitive inhibitors of Helicobacter pylori type II dehydroquinase: Synthesis, biological evaluation, and NMR studies2008
Dr Heather Lamb
Professor Alastair Hawkins
Dinucleotide-sensing proteins: linking signaling networks and regulating transcription2008
Dr Heather Lamb
Professor Alastair Hawkins
MbeA and MbeC, proteins key to ColE1 plasmid mobilisation, interact in vitro with a 1 : 1 stoichiometry2008
Dr Heather Lamb
Professor Alastair Hawkins
Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA2008
Dr Heather Lamb
Professor Alastair Hawkins
Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases2007
Dr Heather Lamb
Paul Thompson
Dr Nick Watkins
Professor Alastair Hawkins
Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium2007
Dr Heather Lamb
Professor Alastair Hawkins
Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase2007
Dr Heather Lamb
Professor Alastair Hawkins
Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium2007
Dr Heather Lamb
Professor Alastair Hawkins
Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy2006
Dr David Allen Chalton
Dr Heather Lamb
Professor John Robinson
Professor Jeremy Lakey
Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation2006
Dr Christopher Johnson
Dr Heather Lamb
Professor Alastair Hawkins
Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog2006
Dr Heather Lamb
Christopher Mee
Professor Alastair Hawkins
The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP2006
Dr Heather Lamb
Professor Alastair Hawkins
GTP cyclohydrolase II structure and mechanism2005
Dr Alison Park
Dr Heather Lamb
Professor Alastair Hawkins
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein2004
Dr Heather Lamb
Dr Alison Park
Dr Christopher Johnson
Dr Simon Cocklin
Paul Thompson
et al.
Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis2004
Dr Heather Lamb
Professor Alastair Hawkins
Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase2003
Dr Heather Lamb
Dr Anna Dodds
Dr Christopher Johnson
Professor Alastair Hawkins
The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides2003
Professor Alastair Hawkins
Dr Heather Lamb
A thermodynamic study of the reactions: {2-dehydro-3-deoxy-D-arabino-heptanoate 7-phosphate(aq) = 3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq) = 3-dehydroshikimate(aq) + H2O(1)}2002
Dr Heather Lamb
Demonstration of Hot Start characteristics in Transgenomic Optimase (TM) polymerase2002
Dr Carys Watts
Dr Heather Lamb
Professor Alastair Hawkins
Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins2002
Dr Alison Spiers
Dr Heather Lamb
Dr Simon Cocklin
Dr Anna Dodds
Professor Alastair Hawkins
et al.
PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide2002
Dr Heather Lamb
Predicting the optimal PCR primer annealing temperature for use with the Transgenomic Optimase (TM) polymerase.2002
Dr Simon Cocklin
Dr Anna Dodds
Dr Heather Lamb
Professor Alastair Hawkins
Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression2001
Dr Heather Lamb
Faye Haldane
Professor Alastair Hawkins
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase2001
Dr Heather Lamb
Dr Simon Cocklin
Dr Anna Dodds
Professor Alastair Hawkins
The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases2001
Dianne Smith
Dr Heather Lamb
Professor Alastair Hawkins
Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein2000
Dr Heather Lamb
Alan Leake
Professor Ian McKeith
Emeritus Professor Robert Perry
Dr Christopher Morris
et al.
No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies1997
Dr Heather Lamb
Alan Leake
Professor Ian McKeith
Emeritus Professor Robert Perry
Dr Christopher Morris
et al.
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease1997
Dr Christopher Morris
Alan Leake
Dr Michael Griffiths
Dr Heather Lamb
Andrew Brown
et al.
Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias1996