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Browsing publications by Emeritus Professor Paul Flecknell.

Newcastle AuthorsTitleYearFull text
Dr Amy Miller
Dr Jasmine Clarkson
Emma Geijer Simpson
Emeritus Professor Paul Flecknell
Dr Matthew Leach
et al.
Evaluating pain and analgesia effectiveness following routine castration in rabbits using behaviour and facial expressions2022
Henri Bertrand
Emeritus Professor Paul Flecknell
A cervical mass in a laboratory rhesus macaque (Macaca mulatta): Suspicion of air sacculitis2021
Henri Bertrand
Professor Stuart Baker
Emeritus Professor Paul Flecknell
Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)2021
Dr Jasmine Clarkson
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Professor Candy Rowe
Negative mood affects the expression of negative but not positive emotions in mice.2020
Emeritus Professor Paul Flecknell
Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats: A Systematic Review2020
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Dr Claire Witham
Opportunities for Refinement in Neuroscience: Indicators of Wellness and Post-operative Pain in Laboratory Macaques12019
Dr Colline Poirier
Caitlin Oliver
Janire Castellano Bueno
Emeritus Professor Paul Flecknell
Professor Melissa Bateson
et al.
Pacing behaviour in laboratory macaques is an unreliable indicator of acute stress2019
Dr Jenny Lofgren
Dr Amy Miller
Carla Bradshaw
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
et al.
Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models2018
Dr Jasmine Clarkson
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Professor Candy Rowe
Handling method alters the hedonic value of reward in laboratory mice2018
Henri Bertrand
Emeritus Professor Paul Flecknell
Reported analgesic and anaesthetic administration to non-human primates undergoing experimental surgical procedure: 2010-20152018
Henri Bertrand
Charlotte Sanders
Emeritus Professor Paul Flecknell
The use of desflurane for neurosurgical procedures in rhesus macaque (Macaca mulatta)2018
Henri Bertrand
Charlotte Sanders
Jennifer Murray
Emeritus Professor Paul Flecknell
A combination of alfaxalone, medetomidine and midazolam for the chemical immobilization of Rhesus macaque (Macaca mulatta): Preliminary results2017
Emeritus Professor Paul Flecknell
Dr Aurelie Thomas
Comparative Anesthesia and Analgesia of Laboratory Animals2017
Henri Bertrand
Svenja Springer
Emeritus Professor Paul Flecknell
Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure2017
Dr Aurelie Thomas
Emeritus Professor Paul Flecknell
Minimally invasive technique for intrathecal administration of morphine in rats: practicality and antinociceptive properties2017
Henri Bertrand
Emeritus Professor Paul Flecknell
Preliminary assessment of midazolam, fentanyl and fluanisone combination for the sedation of rhesus macaques (Macaca mulatta)2017
Emeritus Professor Paul Flecknell
Translational pain assessment: Could natural animal models be the missing link?2017
Henri Bertrand
Dr Aurelie Thomas
Yvette Ellen
Robert Dorward
Emeritus Professor Paul Flecknell
et al.
A surgical approach in the treatment of preputial gland abscesses in mice2016
Henri Bertrand
Yvette Ellen
Stevie O'Keefe
Emeritus Professor Paul Flecknell
Comparison of the effects of ketamine and fentanyl-midazolam-medetomidine for sedation of rhesus macaques (Macaca mulatta)2016
Dr Aurelie Thomas
Dr Amy Miller
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Efficacy of intrathecal morphine in a model of surgical pain in rats2016
Emeritus Professor Paul Flecknell
Enhancing collaboration in the UK animal welfare research community2016
Yvette Ellen
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Evaluation of Using Behavioural Changes to Assess Post-Operative Pain in the Guinea Pig (Cavia porcellus)2016
Emeritus Professor Paul Flecknell
Hospice and palliative care2016
Emeritus Professor Paul Flecknell
Opportunities for improving animal welfare in rodent models of epilepsy and seizures2016
Dr Helen Gray
Henri Bertrand
Claire Mindus
Emeritus Professor Paul Flecknell
Professor Candy Rowe
et al.
Physiological, behavioral, and scientific impact of different fluid control protocols in the rhesus macaque (Macaca mulatta)2016
Dr Amy Miller
Ben Skalkoyannis
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Using the mouse grimace scale and behaviour to assess pain in CBA mice following vasectomy2016
Emeritus Professor Paul Flecknell
Dr Jenny Lofgren
Chapter 24 - Preanesthesia, Anesthesia, Analgesia, and Euthanasia2015
Dr Simon Hill
Professor Simon Thomas
Emeritus Professor Paul Flecknell
Dr Aurelie Thomas
Dr Christopher Morris
et al.
Rapid and equivalent systemic bioavailability of the antidotes HI-6 and dicobalt edetate via the intraosseous and intravenous routes2015
Aimen Amer
Dr Phillip Probert
Dr Michael Dunn
Margaret Knight
Dr Abigail Vallance
et al.
Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation2015
Dr Malcolm Coulthard
Dr Clive Griffiths
Dr Michael Drinnan
Professor John Matthews
Emeritus Professor Paul Flecknell
et al.
Haemodialysing babies weighing <8 kg with the Newcastle infant dialysis and ultrafiltration system (Nidus): comparison with peritoneal and conventional haemodialysis2014
Dr Johnny Roughan
Claire Coulter
Emeritus Professor Paul Flecknell
Huw Thomas
The Conditioned Place Preference Test for Assessing Welfare Consequences and Potential Refinements in a Mouse Bladder Cancer Model2014
Emeritus Professor Paul Flecknell
Dr Aurelie Thomas
A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice2013
Graciela Rocha
Dr Johnny Roughan
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Professor Colin Ingram
et al.
Antinociceptive Activities of Hyptis crenata Pohl2013
Siân Wright-Williams
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
Comparative Effects of Vasectomy Surgery and Buprenorphine Treatment on Faecal Corticosterone Concentrations and Behaviour Assessed by Manual and Automated Analysis Methods in C57 and C3H Mice2013
Dr Amy Miller
Siân Wright-Williams
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice2012
Dr Aurelie Thomas
Dr Matthew Leach
Emeritus Professor Paul Flecknell
An alternative method of endotracheal intubation of common marmosets (Callithrix jacchus).2012
Dr Matthew Leach
Kristel Klaus
Dr Amy Miller
Emeritus Professor Paul Flecknell
Are we looking in the right place? - Implications for assessing pain2012
Dr Aurelie Thomas
Emeritus Professor Paul Flecknell
Dr Huw Golledge
Combining Nitrous Oxide with Carbon Dioxide decreases the time to loss of consciousness during euthanasia in mice — refinement of animal welfare?2012
Dr Stephanie Keating
Dr Aurelie Thomas
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses2012
Veronique Brieuc
Emeritus Professor Paul Flecknell
Dr Amy Miller
Dr Matthew Leach
Peut-on utilliser les expressions faciales pour étudier la douleur chez les rongeurs? (Can we use facial expressions to study pain in rodents?)2012
Emeritus Professor Paul Flecknell
Response to Westlund's commentary: 'Can conditioned reinforcers and variable-Ratio Schedules make food- and fluid control redundant?'2012
Dr Matthew Leach
Dr Amy Miller
Emeritus Professor Paul Flecknell
The Assessment of Post-Vasectomy Pain in Mice using Behaviour and the Mouse Grimace Scale2012
Dr Amy Miller
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Dr Johnny Roughan
A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice2011
Susan Stamp
Dr Kathryn White
Dr Katrina Wood
Dr Aurelie Thomas
Annie Russell
et al.
A novel perfusion fluid for DCD donor kidneys; better as a flush or a storage medium?2011
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Professor Melissa Bateson
Affective state and quality of life in mice2011
Dr Matthew Leach
Claire Coulter
Dr Claire Richardson
Emeritus Professor Paul Flecknell
Are We Looking in the Wrong Place? Implications for Behavioural-Based Pain Assessment in Rabbits (Oryctolagus cuniculi) and Beyond?2011
Dr Chris Ray
Susan Stamp
Dr Kathryn White
Dr Katrina Wood
Dr Aurelie Thomas
et al.
Large animal renal allotransplantation; a porcine recovery model to assess delayed graft function2011
Emeritus Professor Paul Flecknell
Dr Matthew Leach
Dr Claire Richardson
Reported analgesic administration to rabbits undergoing experimental surgical procedures2011
Dr Huw Golledge
Emeritus Professor Paul Flecknell
The effect of behavioural state and cage environment on responses to euthanasia with isoflurane or carbon dioxide in BALB/c mice2011
Dr Matthew Leach
Dr Amy Miller
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
A preliminary investigation into the practicality of use and duration of action of slow-release preparations of morphine and hydromorphone in laboratory rats2010
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine2010
Steven White
Professor James Shaw
Emeritus Professor Paul Flecknell
Professor Alastair Burt
Professor Matthew Wright
et al.
Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo2010
Dr Karen Wallace
Emeritus Professor Paul Flecknell
Professor Alastair Burt
Professor Matthew Wright
Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid2010
Emeritus Professor Paul Flecknell
Do mice have a pain face?2010
Dr Matthew Leach
Alison Forrester
Emeritus Professor Paul Flecknell
Influence of preferred foodstuffs on the antinociceptive effects of orally administered buprenorphine in laboratory rats2010
Dr Amy Miller
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Mesure de la fiabilité et de la precision des expressions facials pour évaluer la douler chez la souris2010
Emeritus Professor Paul Flecknell
Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research Report of a Working Group of the NC3Rs2010
Dr Matthew Leach
Emeritus Professor Paul Flecknell
The use of propofol and sevoflurane for surgical anaesthesia in New Zealand White rabbits2010
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice2009
Dr Matthew Leach
Dr Claire Richardson
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits2009
Dr Matthew Leach
Dr Claire Richardson
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Identifying potential behavioural indicators of pain in rabbits following ovariohysterectomy - Preliminary study2009
Dr Amy Miller
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Influence of early neonatal experience on nociceptive responses and analgesic effects in rats2009
Emeritus Professor Paul Flecknell
Laboratory Animal Anaesthesia2009
Claire Coulter
Emeritus Professor Paul Flecknell
Dr Claire Richardson
Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures2009
Emeritus Professor Paul Flecknell
Dr Claire Richardson
Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures2009
Dr Amy Miller
Dr Matthew Leach
Emeritus Professor Paul Flecknell
The analgesic effects of oral paracetamol in two strains of mice undergoing vasectomy2009
Graciela Rocha
Dr Johnny Roughan
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Professor Colin Ingram
et al.
Traditional use, chemical analysis and antinociceptive effects of Hyptis crenato Pohl2009
Emeritus Professor Paul Flecknell
Analgesia from a veterinary perspective2008
Emeritus Professor Paul Flecknell
Jon Gledhill
Dr Claire Richardson
Assessing animal health and welfare and recognising pain and distress2007
Dr Claire Richardson
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse2007
Dr Claire Richardson
Lee Niel
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Evaluation of the efficacy of a novel electronic pain assessment device, the Pain Gauge®, for measuring postoperative pain in rats2007
Emeritus Professor Paul Flecknell
Dr Claire Richardson
Laboratory Animals2007
Emeritus Professor Paul Flecknell
Assessing the welfare of genetically altered mice2006
Dr Huw Golledge
Dr Matthew Leach
Emeritus Professor Paul Flecknell
Newcastle Consensus Meeting on Carbon Dioxide Euthanasia of Laboratory Animals2006
Dr Claire Richardson
Emeritus Professor Paul Flecknell
Routine neutering of rabbits and rodents2006
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Training in behaviour-based post-operative pain scoring in rats - An evaluation based on improved recognition of analgesic requirements2006
Dr Claire Richardson
Emeritus Professor Paul Flecknell
Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: Are we making progress?2005
Hannah Orr
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit2005
Rakesh Rai
Emeritus Professor Paul Flecknell
Dr Claire Richardson
Professor Derek Manas
Creation of porcine liver tumor using human hepatoma cell lines: Experimental study2005
Emeritus Professor Paul Flecknell
Partnerships for progress2005
Dr Claire Richardson
Emeritus Professor Paul Flecknell
Dr Helen Robertson
Professor Alastair Burt
Professor Derek Manas
et al.
Study of apoptosis and heat shock protein (HSP) expression in hepatocytes following radiofrequency ablation (RFA)2005
Dr Nilofer Sabrine
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
[abstract] Assessment of post-operative pain in infants and neonates2004
Emeritus Professor Paul Flecknell
Assessing and managing pain and distress for ethics committees2004
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
Assessing pain in animals - Putting research into practice2004
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Dr Barry Davies
Behavioural assessment of the effects of tumour growth in rats and the influence of tne analgesics carprofen and meloxicam2004
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats2004
Luis Antunes
Dr Huw Golledge
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat2003
Luis Antunes
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Effects of different propofol infusion rates on EEG activity and AEP responses in rats2003
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Evaluation of a short duration behaviour-based post-operative pain scoring system in rats2003
Luis Antunes
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Excitatory effects of fentanyl upon the rat electroencephalogram and auditory-evoked potential responses during anaesthesia2003
Professor Simi Ali
Professor John Kirby
Emeritus Professor Paul Flecknell
Professor John Dark
Improvements in lung compliance after pulmonary transplantation: Correlation with interleukin 8 expression2003
Dr Doug Aitchison
Hannah Orr
Emeritus Professor Paul Flecknell
Professor John Kirby
Professor John Dark
et al.
Nitric oxide during perfusion improves posttransplantation function of non-heart-beating donor lungs2003
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Pain assessment and control in laboratory animals2003
Emeritus Professor Paul Flecknell
Professor John Dark
Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury2003
Hannah Orr
Dr Johnny Roughan
Luis Antunes
Emeritus Professor Paul Flecknell
Anaesthesia with ketamine/medetomidine in the rabbit: influence of route of administration and the effect of combination with butorphanol2002
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals2002
Emeritus Professor Paul Flecknell
Professor Jonathan Rees
Production of acute and chronic itch with histamine and contact sensitizers in the mouse and guinea pig2002
Dr Malcolm Coulthard
Emeritus Professor Paul Flecknell
Hannah Orr
Professor Derek Manas
Dr Marie O'Donnell
et al.
Renal scaring caused by vesicoureteric reflux and urinary infection: A study in pigs2002
Emeritus Professor Paul Flecknell
Replacement, reduction and refinement2002
Emeritus Professor Paul Flecknell
Replacement, reduction and refinement2002
Diana Levett
Emeritus Professor Paul Flecknell
Professor David Neal
Kilian Mellon
Dr Barry Davies
et al.
Transfection of S100A4 produces metastatic variants of an orthotopic model of bladder cancer2002
Emeritus Professor Paul Flecknell
Analgesia of small mammals2001
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats2001
Dr Doug Aitchison
Hannah Orr
Emeritus Professor Paul Flecknell
Professor John Kirby
Professor John Dark
et al.
Functional assessment of non-heart-beating donor lungs: Prediction of post-transplant function2001
Dr Johnny Roughan
Luis Antunes
Hannah Orr
Emeritus Professor Paul Flecknell
Induction of anaesthesia with desflurane and isoflurane in the rabbit2001
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats2000
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats2000
Emeritus Professor Paul Flecknell
Pain Management in Animals2000
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Sufentanil and medetomidine anaesthesia in the rat and its reversal with atipamezole and butorphanol2000
Dr Gavin Clowry
Emeritus Professor Paul Flecknell
The successful use of fentanyl/fluanisone ('Hypnorm') as an anaesthetic for intracranial surgery in neonatal rats2000
Emeritus Professor Paul Flecknell
A comparison of pre- and post-surgical administration of bupivacaine or buprenorphine following laparotomy in the rat1999
Stephen Clark
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Professor John Dark
A new porcine model of reperfusion injury after lung transplantation1999
Emeritus Professor Paul Flecknell
Hannah Orr
Dr Johnny Roughan
Robert Stewart
Comparison of the effects of oral or subcutaneous carprofen or ketoprofen in rats undergoing laparotomy.1999
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
Induction of anaesthesia with sevoflurane and isoflurane in the rabbit1999
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
Professor John Dark
Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and SIN-11999
Dr Johnny Roughan
Emeritus Professor Paul Flecknell
The influence of pre-anaesthetic administration of buprenorphine on the anaesthetic effects of ketamine/medetomidine and pentobarbitone in rats and the consequences of repeated anaesthesia1999
Emeritus Professor Paul Flecknell
Dr Johnny Roughan
Robert Stewart
Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats - A clinical trial1999