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Browsing publications by Professor Steven Clifford.

Newcastle AuthorsTitleYearFull text
Dr Stacey Richardson
Professor Steven Clifford
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation2022
Dr Rebecca Hill
Professor Steven Clifford
Professor Simon Bailey
Relapsed medulloblastoma in pre-irradiated patients: Current practice for diagnostics and treatment2022
Professor Simon Bailey
Professor Steven Clifford
Acceptance and commitment therapy for young brain tumour survivors: Study protocol for an acceptability and feasibility trial2021
Dr Stephen Crosier
Dr Debbie Hicks
Dr Ed Schwalbe
Dr Daniel Williamson
Amanda Smith
et al.
Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics2021
Professor Simon Bailey
Professor Steven Clifford
Dr Dipayan Mitra
Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors2021
Professor Steven Clifford
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation2021
Dr Marina Danilenko
Professor Steven Clifford
Dr Ed Schwalbe
Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma2021
Professor Steven Clifford
SIOP PNET5 MB trial: History and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma2021
Dr Debbie Hicks
Dr Reza Rafiee
Dr Ed Schwalbe
Dr Christopher Howell
Dr Janet Lindsey
et al.
The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes2021
Dr Ed Schwalbe
Dr Debbie Hicks
Professor Steven Clifford
Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: Results from the prospective multicenter HIT-SIOP PNET 4 study2020
Dr Matthew Selby
Dr Daniel Williamson
Professor Steven Clifford
Erratum: Author Correction: VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells (Communications biology (2020) 3 1 (579))2020
Professor Steven Clifford
Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma – A Report From the HIT 2000 Trial2020
Dr Yura Grabovska
Dr Stephen Crosier
Dr Martina Finetti
Dr Ed Schwalbe
Dr Rebecca Hill
et al.
Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity2020
Dr Rebecca Hill
Dr Stacey Richardson
Dr Ed Schwalbe
Dr Debbie Hicks
Dr Janet Lindsey
et al.
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study2020
Professor Steven Clifford
VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells2020
Dr Rebecca Hill
Professor Steven Clifford
Yura Grabovska
Dr Daniel Williamson
DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study2019
Professor Steven Clifford
Dr Ed Schwalbe
Dr Debbie Hicks
Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort2019
Professor Steven Clifford
Professor David Ellison
Medulloblastoma2019
Dr Ed Schwalbe
Dr Daniel Williamson
Dr Janet Lindsey
Dr Rebecca Hill
Dr Debbie Hicks
et al.
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes2019
Dr Daniel Williamson
Dr Christopher Jones
Professor Steven Clifford
Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group2018
Dr Ed Schwalbe
Dr Debbie Hicks
Professor Steven Clifford
Prognostic impact of whole chromosomal 1 aberration signatures in standard-risk non-WNT/non-SHH medulloblastoma: a retrospective molecular analysis of the HIT-SIOP-PNET4 clinical trial2018
Professor Steven Clifford
Dr Debbie Hicks
Dr Janet Lindsey
Dr Rebecca Hill
Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours2017
Dr Ed Schwalbe
Dr Debbie Hicks
Dr Reza Rafiee
Dr Matthew Bashton
Dr Amir Enshaei
et al.
Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures2017
Dr Ed Schwalbe
Dr Janet Lindsey
Dr Sirintra Nakjang
Dr Stephen Crosier
Amanda Smith
et al.
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study2017
Dr Matthew Selby
Dr Daniel Williamson
Professor Steven Clifford
TAp73 is a marker of glutamine addiction in medulloblastoma2017
Dr Stephen Crosier
Dr Debbie Hicks
Dr Ed Schwalbe
Dr Daniel Williamson
Sarah Nicholson
et al.
Centralised Molecular Pathology for Rare Tumours: A National Feasibility Study of Real-Time Medulloblastoma Diagnostics2016
Professor Steven Clifford
Distinct Gene Fusions Segregate Sub-Classes of CNS-PNETs2016
Professor Simon Bailey
Dr Janet Lindsey
Professor Steven Clifford
Divergent clonal selection dominates medulloblastoma at recurrence2016
Professor Steven Clifford
Dr Stephen Crosier
Dr Debbie Hicks
Stewart Nicholson
Dr Nicholas Bown
et al.
Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB)2016
Professor Steven Clifford
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled SIOP-E and head start data2016
Dr Ed Schwalbe
Dr Debbie Hicks
Professor Steven Clifford
Health-Related Quality of Life (HRQoL) in HIT-SIOP-PNET4 trial survivors: differences between medulloblastoma molecular subgroups2016
Professor Steven Clifford
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours2016
Dr Debbie Hicks
Dr Ed Schwalbe
Dr Stephen Crosier
Professor Simon Bailey
Dr Daniel Williamson
et al.
Identification of medulloblastoma molecular subgroups using metabolite profiles2016
Dr Martina Finetti
Matthew Selby
Dr Matthew Bashton
Dr Ruth Cranston
Dr Stephen Crosier
et al.
Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities2016
Dr Martina Finetti
Alicia Del Carpio Pons
James Barker
James Wood
Dr Sirintra Nakjang
et al.
Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities2016
Matthew Selby
Dr Martina Finetti
Dr Matthew Bashton
Dr Ruth Cranston
Alicia Del Carpio Pons
et al.
Investigating the biology of atypical teratoid/rhabdoid tumors by whole genome CRISPR/CAS9 screening2016
Dr Janet Lindsey
Dr Rebecca Hill
Dr Ed Schwalbe
Dr Christopher Howell
Dr Reza Rafiee
et al.
Molecular and Prognostic Heterogeneity within MYC and MYCN Amplified Medulloblastomas2016
Dr Debbie Hicks
Professor Steven Clifford
Molecular Subgrouping of Medulloblastoma with nanostring technology: A feasibility study for routine real-time procedures2016
Professor Steven Clifford
Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study2016
Professor Simon Bailey
Professor Steven Clifford
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus2016
Dr Ed Schwalbe
Dr Debbie Hicks
Dr Reza Rafiee
Dr Matthew Bashton
Dr Amir Enshaei
et al.
Routine Diagnostic Medulloblastoma Subgrouping Using Low-Cost, Low-Input DNA Methylomics: Application to Trials Cohorts Previously Refractory-to-Analysis2016
Dr Ed Schwalbe
Dr Debbie Hicks
Dr Reza Rafiee
Dr Matthew Bashton
Dr Amir Enshaei
et al.
Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics2016
Dr Debbie Hicks
Dr Reza Rafiee
Dr Ed Schwalbe
Dr Christopher Howell
Dr Janet Lindsey
et al.
Subgroup-Directed Stratification of Risk in Infant Medulloblastoma2016
Dr Daniel Williamson
Dr Janet Lindsey
Dr Debbie Hicks
Dr Stephen Crosier
Amanda Smith
et al.
The Transcriptional Landscape of Medulloblastoma: Group 3 and Group 4 Tumours Comprise a Single Clinically Significant Expression Continuum2016
Professor Steven Clifford
Dr Ed Schwalbe
Dr Debbie Hicks
Kieran O'Toole
Sarah Nicholson
et al.
Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial2015
Professor Steven Clifford
Dr Ed Schwalbe
Dr Debbie Hicks
Kieran O'Toole
Sarah Nicholson
et al.
Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial2015
Dr Rebecca Hill
Dr Janet Lindsey
Dr Ed Schwalbe
Dr Karen Barker
Dr Daniel Williamson
et al.
Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease2015
Dr Janet Lindsey
Dr Ed Schwalbe
Matthew Selby
Dr James Hayden
Dr Daniel Williamson
et al.
Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance2015
Dr Ed Schwalbe
Professor Steven Clifford
DNA Methylation Analysis of Paediatric Low-Grade Astrocytomas Identifies a Tumour-Specific Signature at a Set of Enhancers2015
Dr Al Gabriel
Fadhel Alsaid Naji
Dr Ed Schwalbe
Dr Sirintra Nakjang
Dr Simon Cockell
et al.
Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia2015
Dr Janet Lindsey
Dr Ed Schwalbe
Sandeep Potluri
Professor Simon Bailey
Dr Daniel Williamson
et al.
TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours2014
Dr Martina Finetti
Alicia Del Carpio Pons
Ben Skalkoyannis
Matthew Selby
Amanda Smith
et al.
A Systems Biology Approach to Identify Mechanism of Tumourigenesis Caused by Loss of SMARCB1 in Malignant Rhabdoid Tumors (BACR28)2014
Professor Simon Bailey
Professor David Ellison
Professor Steven Clifford
An Exploration of Associations between Health Related Quality of Life and Medulloblastoma Molecular Subgroup Status in Survivors from the SIOP UKCCSG PNET3 Trial2014
Dr Martina Finetti
Matthew Selby
Dr Stephen Crosier
Ben Skalkoyannis
Professor Simon Bailey
et al.
Characterising critical pathways in ATRT tumourigenesis: a genome-wide analysis of primary tumours and functional genomic models2014
Professor Steven Clifford
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity2014
Dr Janet Lindsey
Dr Ed Schwalbe
Dr James Hayden
Professor David Ellison
Dr Daniel Williamson
et al.
Cross-Species Epigenetics Identifies a Critial Role for VAV1 in the Maintenance of Sonic Hedgehog Subgroup Medulloblastomas2014
Professor Simon Bailey
Dr Janet Lindsey
Professor Steven Clifford
Cytogenetic Prognostication Within Medulloblastoma Subgroups2014
Professor Steven Clifford
Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system2014
Professor Simon Bailey
Professor David Ellison
Professor Steven Clifford
Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors2014
Dr Martina Finetti
Ben Skalkoyannis
Matthew Selby
Dr Stephen Crosier
Professor Simon Bailey
et al.
Mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumors2014
Professor Simon Bailey
Professor Steven Clifford
Dr Daniel Williamson
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group2014
Dr Rebecca Hill
Dr Janet Lindsey
Dr Ed Schwalbe
Dr Daniel Williamson
Dr Sarra Ryan
et al.
MYC and TP53 defects emerge and interact at medulloblastoma relapse, define rapidly progressive disease and can be targeted therapeutically2014
Dr Rebecca Hill
Dr Janet Lindsey
Dr Ed Schwalbe
Dr Karen Barker
Dr Daniel Williamson
et al.
MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically2014
Dr Martina Finetti
Matthew Selby
Alicia Del Carpio Pons
Ben Skalkoyannis
Amanda Smith
et al.
Next-generation sequencing identifies the mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumours2014
Professor Steven Clifford
Prognostic Factors in Childhood CNS-PNET and Pineblastoma: An International Meta-Analysis of Original Clinical Data2014
Dr Ed Schwalbe
Dr Debbie Hicks
Dr Reza Rafiee
Dr Amir Enshaei
Sandeep Potluri
et al.
Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost DNA methylomics2014
Professor Steven Clifford
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma2014
Professor Steven Clifford
Dr Stephen Crosier
Sarah Nicholson
Dr Nicholas Bown
A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma2013
Dr Ed Schwalbe
Dr Daniel Williamson
Dr Janet Lindsey
Dolores Hamilton
Sarra Ryan
et al.
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies2013
Dr Ed Schwalbe
Dr James Hayden
Dr Janet Lindsey
Dr Rebecca Hill
Sarah Nicholson
et al.
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types2013
Dr Maria Lastowska
Hani Al-Afghani
Haya AL-Balool
Harsh SHETH
Dr Jonathan Coxhead
et al.
Identification of a neuronal transcription factor network involved in medulloblastoma development2013
Dr Matthew Allen
Dr Daniel Williamson
Professor Steven Clifford
Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells2013
Dr Rebecca Hill
Dr Janet Lindsey
Dr Ed Schwalbe
Professor Simon Bailey
Professor Steven Clifford
et al.
Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma2013
Dr Sarra Ryan
Dr Ed Schwalbe
Mike Cole
Yuan Lu
Dr Meryl Lusher
et al.
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma2012
Dr Stephen Crosier
Sarah Nicholson
Dr Nicholas Bown
Professor Steven Clifford
A National Feasibility Study of Real-Time Central Pathology Review and Molecular Diagnostics for Medulloblastoma2012
Dr Daniel Williamson
Professor Steven Clifford
A significant proportion of medulloblastoma do not sub-group robustly: Identification of a molecular NOS (not otherwise specified) subgroup2012
Dr Daniel Williamson
Professor Steven Clifford
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma2012
Professor Steven Clifford
Cancer Genetics: Evolution after tumour spread2012
Professor Steven Clifford
Delineating the genomic differences between primary and recurrent medulloblastoma2012
Dr Daniel Williamson
Professor Steven Clifford
Dissecting the genomic complexity underlying medulloblastoma2012
Dr Ed Schwalbe
Dr Janet Lindsey
Dr Daniel Williamson
Kieran O'Toole
Dr Meryl Lusher
et al.
Epigenetic sub-classification and risk-stratification of medulloblastoma using DNA methylomics2012
Professor Steven Clifford
Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial2012
Dr James Hayden
Dr Christopher Jones
Professor Steven Clifford
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis2012
Professor Steven Clifford
Professor David Ellison
Dr Richard Gilbertson
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas2012
Professor Steven Clifford
Professor David Ellison
Dr Richard Gilbertson
Molecular subgroups of medulloblastoma: the current consensus2012
Professor Steven Clifford
Polo-Like Kinase 1 (PLK1) Inhibition Reduces Cell Proliferation and Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia2012
Professor Steven Clifford
Prognostic and therapeutic role of TP53 mutations in medulloblastoma subgroups; therapeutic role of lithium in abrogation of TP53 mutation associated radiation resistance2012
Dr Janet Lindsey
Professor Simon Bailey
Professor Steven Clifford
Subgroup-specific structural variation across 1,000 medulloblastoma genomes2012
Dr Ed Schwalbe
Professor Steven Clifford
Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death2012
Dr Jonathan Fisher
Lisa Price
Dr Juliet Hale
Professor Steven Clifford
Professor Simon Bailey
et al.
The importance of biopsy following radiological diagnosis of relapsed medulloblastoma2012
Sarah Nicholson
Dr Nicholas Bown
Professor Steven Clifford
A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom2011
Professor David Ellison
Dr Hisham Megahed
Dr Meryl Lusher
Dr Sarra Ryan
Professor Simon Bailey
et al.
Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables2011
Dr Ed Schwalbe
Professor Steven Clifford
Genome-Wide Analysis of Alternative Splicing in Medulloblastoma Identifies Splicing Patterns Characteristic of Normal Cerebellar Development2011
Dr Vikki Rand
Professor Steven Clifford
Dr James Hayden
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma2011
Professor Steven Clifford
Medulloblastoma Comprises Four Distinct Molecular Variants2011
Professor David Ellison
Sarah Nicholson
Professor Simon Bailey
Professor Steven Clifford
Dr Richard Gilbertson
et al.
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups2011
Dr Ed Schwalbe
Professor Steven Clifford
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance2011
Professor Steven Clifford
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct2011
Dr Ed Schwalbe
Dr Janet Lindsey
Debbie Straughton
Mike Cole
Dr Hisham Megahed
et al.
Rapid Diagnosis of Medulloblastoma Molecular Subgroups2011
Dr Meryl Lusher
Dr Janet Lindsey
Professor Steven Clifford
RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines2011
Dr Janet Lindsey
Dr Rebecca Hill
Dr Hisham Megahed
Dr Meryl Lusher
Dr Ed Schwalbe
et al.
TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas2011
Rachel Daniel
Dr Agata Rozanska
Dr Evan Mulligan
Dr Yvette Drew
Huw Thomas
et al.
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-0146992010
Dr Ed Schwalbe
Professor Steven Clifford
Dr Richard Gilbertson
Characteristic Genomic Imbalances in Paediatric Ependyoma; The Importance of Chromosome 1Q Gain2010
Dr Hisham Megahed
Dr Sarra Ryan
Dr Meryl Lusher
Sarah Nicholson
Professor Simon Bailey
et al.
Clinical, Pathological, and Molecular Variables Define Risk-Stratification Groups in Childhood Medulloblastoma2010
Professor David Ellison
Dr Hisham Megahed
Dr Sarra Ryan
Dr Meryl Lusher
Sarah Nicholson
et al.
Clinical, pathological, and molecular variables define risk-stratification groups in childhood medulloblastoma2010
Dr Ed Schwalbe
Dr Janet Lindsey
Dr Meryl Lusher
Kieran O'Toole
Sarah Nicholson
et al.
DNA methylomics identifies clinically significant epigenetic subgroups of medulloblastoma2010
Sarah Nicholson
Dr Nicholas Bown
Professor Steven Clifford
Establishment of real-time centralised pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom2010
Dr James Hayden
Dr Matthew Allen
Dr Sarra Ryan
Sarah Nicholson
Dr Ed Schwalbe
et al.
Molecular Mechanisms in Supratentorial CNS-PNET development2010
Professor Steven Clifford
Dr Sarra Ryan
Mike Cole
Dr Meryl Lusher
Kieran O'Toole
et al.
MYC gene family amplification and expression in childhood medulloblastoma: Biological significance and utility for high-risk disease stratification2010
Dr Britta Vormoor
Professor Nicola Curtin
Professor Steven Clifford
Sensitisation of paediatric solid tumours to DNA-damaging chemotherapy by inhibition of DNA-dependent protein kinase (PRKDC)2010
Professor Steven Clifford
Stratification of children and adolescents with medulloblastoma by histological and biological parameters in SIOP-Europe PNET clinical trials2010
Dr Janet Lindsey
Professor Steven Clifford
Professor David Ellison
Dr Richard Gilbertson
Subtypes of medulloblastoma have distinct developmental origins2010
Dr Agata Rozanska
Dr Evan Mulligan
Huw Thomas
Deborah Castelbuono
Professor Deborah Tweddle
et al.
[abstract] Central nervous system (CNS) penetration, poly-ADP ribose polymerase (PARP) inhibition and enhancement of temozolomide activity against childhood medulloblastoma by AG-0146992009
Professor Steven Clifford
Dr Nicholas Bown
A feasibility study of real-time biological characterisation of medulloblastoma in the United Kingdom2009
Dr Sarra Ryan
Professor David Elliott
Professor David Ellison
Professor Simon Bailey
Professor Steven Clifford
et al.
Amplification and overexpression of Hsa-miR-3ob, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma2009
Professor Steven Clifford
Kieran O'Toole
Professor David Ellison
Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers2009
Dr James Hayden
Professor David Ellison
Professor Simon Bailey
Professor Steven Clifford
Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children2009
Professor Steven Clifford
Professor David Ellison
Kieran O'Toole
Improved Stratification of Standard Risk Medulloblastoma Patients by Clinical and Biological Prognostic Factors2009
Dr Agata Rozanska
Huw Thomas
Dr Evan Mulligan
Dr Yvette Drew
Deborah Castelbuono
et al.
Inhibition of Poly (ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma2009
Dr Janet Lindsey
Professor Steven Clifford
Methylation-Controlled J Protein2009
Professor Steven Clifford
Professor David Ellison
Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint2009
Professor Steven Clifford
The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials2009
Jennifer Anderton
Dr Janet Lindsey
Dr Meryl Lusher
Dr Richard Gilbertson
Professor Simon Bailey
et al.
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A22008
Professor David Ellison
Professor Steven Clifford
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features2008
Professor Steven Clifford
KidsCancerKinome: a EU-FP6 project for preclinical kinase inhibitor evaluation as a tool to prioritize compounds for paediatric development2008
Professor Steven Clifford
Medulloblastoma: new insights into biology and treatment2008
Professor Steven Clifford
Dr Meryl Lusher
Dr Janet Lindsey
Dr Jackie Langdon
Dr Richard Gilbertson
et al.
Wnt-pathway medulloblastomas2008
Professor David Ellison
Dr Janet Lindsey
Dr Meryl Lusher
Professor Steven Clifford
Beta-catenin status predicts favorable prognosis in childhood medulloblastoma2007
Professor Steven Clifford
Yuan Lu
Dr Debbie Scott
Professor David Ellison
Chromosome 8 contains multiple independent loci involved in medulloblastoma development2007
Dr Janet Lindsey
Dr Meryl Lusher
Jennifer Anderton
Dr Richard Gilbertson
Professor David Ellison
et al.
Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma2007
Professor Steven Clifford
Expression of drugable targets in pediatric malignancies: Innovative therapies for children with cancer2007
Professor Steven Clifford
Professor David Ellison
Identification of novel mechanisms for gene disruption at the medulloblastoma isochromosome breakpoint locus2007
Charles McManamy
Dr Jane Pears
Professor Steven Clifford
Professor David Ellison
Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior2007
Professor Steven Clifford
Paediatric brain tumours: exploiting genomics to improve therapies2007
Professor Steven Clifford
Rachel Daniel
Dr Agata Rozanska
Huw Thomas
Professor Alan Boddy
et al.
Preclinical evaluation of the POLY-ADP ribose polymerase 1 (PARP-1) inhibitor AG014699 in combination with topotecan and temozolomide for the treatment of medulloblastoma and neuroblastoma2007
Olabisi Onilude
Dr Meryl Lusher
Dr Janet Lindsey
Professor Andrew Pearson
Professor David Ellison
et al.
APC and CTNNB1 mutations are rare in sporadic ependymomas2006
Dr Jackie Langdon
Dr Jayne Lamont
Dr Debbie Scott
Dr Nicholas Bown
Professor David Ellison
et al.
Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma2006
Dr Janet Lindsey
Dr Meryl Lusher
Dr Gordon Strathdee
Robert Brown
Dr Richard Gilbertson
et al.
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours2006
Dr Janet Lindsey
Dr Meryl Lusher
Dr Gordon Strathdee
Dr Richard Gilbertson
Professor Simon Bailey
et al.
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours2006
Dr Poonam Dharmaraj
Dr Stephen Ball
Dr HC Johnstone
Professor Simon Bailey
Professor Steven Clifford
et al.
Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells2006
Dr Debbie Scott
Debbie Straughton
Mike Cole
Professor Simon Bailey
Professor David Ellison
et al.
Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma2006
Dr Richard Gilbertson
Dr Jackie Langdon
Roberto Hernan
Professor Steven Clifford
Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma2006
Professor Steven Clifford
Dr Meryl Lusher
Dr Janet Lindsey
Dr Jackie Langdon
Dr Richard Gilbertson
et al.
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis2006
Professor David Ellison
Olabisi Onilude
Dr Janet Lindsey
Dr Meryl Lusher
Professor Andrew Pearson
et al.
β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee2005
Dr Jayne Lamont
Professor Deborah Tweddle
Professor Andrew Pearson
Professor Steven Clifford
Professor David Ellison
et al.
A 7-year-old boy with midline cerebellar mass2005
Dr Janet Lindsey
Jennifer Anderton
Dr Meryl Lusher
Professor Steven Clifford
Epigenetic events in medulloblastoma development2005
David Hamilton
Dr Meryl Lusher
Dr Janet Lindsey
Professor David Ellison
Professor Steven Clifford
et al.
Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma2005
Dr Kevin Jones
Professor Steven Clifford
Preclinical target analyisis in pediatric malignancies for selecting targeted compounds: Innovative therapies for children with cancer.2005
Dr Christopher Calabrese
Professor Steven Clifford
Dr Richard Gilbertson
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation2005
Dr Christopher Calabrese
Professor Steven Clifford
Dr Richard Gilbertson
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation2005
Professor David Ellison
Professor Andrew Pearson
Professor Steven Clifford
Dr Jayne Lamont
Charles McManamy
et al.
Combined histopathological and molecular cytogenetic stratification defines a high-risk subset of patients with medulloblastoma - A United Kingdom Children's Cancer Group Study2004
Dr Jayne Lamont
Charles McManamy
Professor Andrew Pearson
Professor Steven Clifford
Professor David Ellison
et al.
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients2004
Professor Steven Clifford
Dr Janet Lindsey
Dr Meryl Lusher
Dr Richard Gilbertson
Professor Andrew Pearson
et al.
Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling2004
Dr Janet Lindsey
Dr Meryl Lusher
Jennifer Anderton
Professor Simon Bailey
Dr Richard Gilbertson
et al.
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling2004
Professor David Ellison
Charles McManamy
Professor Andrew Pearson
Professor Steven Clifford
The clinical utility of stratifying medulloblastomas (MBs) by a combination of detailed histopathologic evaluation and molecular cytogenetic analysis2004
Professor Steven Clifford
The molecular genetics and pathology of renal cell carcinoma2004
Dr Adrian Frank
Roberto Hernan
Dr Janet Lindsey
Dr Meryl Lusher
Professor Steven Clifford
et al.
The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma2004
James Cooke
Professor Steven Clifford
Identification of pVHL-interacting proteins and their role in pheochromocytoma development2003
Dr Janet Lindsey
Dr Meryl Lusher
Professor Andrew Pearson
Professor David Ellison
Professor Steven Clifford
et al.
Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling2003
Dr Debbie Scott
Dr Janet Lindsey
Dr Meryl Lusher
Professor Andrew Pearson
Professor David Ellison
et al.
Identification of tumour suppressor loci on chromosome 10q in medulloblastoma2003
Dr Jackie Langdon
Roberto Hernan
Dr Richard Gilbertson
Professor Steven Clifford
Molecular analysis of the PDGFR alpha-RAS/MAPK pathway in childhood medulloblastoma2003
Dr Jayne Lamont
Charles McManamy
Professor Andrew Pearson
Professor Steven Clifford
Professor David Ellison
et al.
Molecular cytogenetic analysis of a cohort of medulloblastomas2003
Charles McManamy
Dr Jayne Lamont
Mike Cole
Professor Andrew Pearson
Professor Steven Clifford
et al.
Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas2003
Dr Richard Gilbertson
Professor Steven Clifford
PDGFRB is overexpressed in metastatic medulloblastoma2003
Professor David Ellison
Professor Steven Clifford
Dr Richard Gilbertson
What's new in neuro-oncology? Recent advances in medulloblastoma2003
Dr Meryl Lusher
Dr Janet Lindsey
Professor Andrew Pearson
Professor David Ellison
Professor Steven Clifford
et al.
Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development2002
Professor Steven Clifford
Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease2002
Professor Steven Clifford
Mucilages and polysaccharides in Ziziphus species (Rhamnaceae): localization, composition and physiological roles during drought-stress2002
Professor Steven Clifford
Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas2001
Professor Steven Clifford
Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas2001
Professor Steven Clifford
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease2001
Professor Steven Clifford
Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease2001
Professor Steven Clifford
The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma2001
Professor Steven Clifford
The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma2001
Professor Steven Clifford
Von Hippel-Lindau disease: clinical and molecular perspectives2001
Professor Steven Clifford
Comparative sequence analysis of the VHL tumor suppressor gene2000
Professor Steven Clifford
Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes2000
Professor Steven Clifford
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein2000
Professor Steven Clifford
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein2000
Professor Steven Clifford
Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations1999
Professor Steven Clifford
Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development1999
Professor Steven Clifford
Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development1999
Professor Steven Clifford
The molecular genetics of renal cell carcinoma1999
Professor Steven Clifford
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis1999
Dr Richard Gilbertson
Professor Steven Clifford
Dr Christopher Wright
Emeritus Professor Robert Perry
Professor Andrew Pearson
et al.
Expression of the ErbB-neuregulin signaling network during human cerebellar development: Implications for the biology of medulloblastoma1998
Professor Steven Clifford
Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes1998
Professor Steven Clifford
Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis1998
Professor Steven Clifford
Professor David Neal
Professor John Lunec
Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder1996
Professor Steven Clifford
Professor David Neal
Professor John Lunec
High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: A potential involvement in protection against carcinogens?1996
Professor Steven Clifford
David Thomas
Professor David Neal
Professor John Lunec

Increased MDR1 gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assay

1994