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Browsing publications by Professor David Thwaites.

Newcastle AuthorsTitleYearFull text
Dr Peter Major
Kacper Sendra
Dr Paul Dean
Dr Tom Williams
Andrew Watson
et al.
A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites2019
Professor David Thwaites
SLC15 family of peptide transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database.2019
Dr Catriona Anderson
Professor David Thwaites
SLC36 family of proton-coupled amino acid transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database.2019
Dr Catriona Anderson
Professor David Thwaites
SLC6A14, a Pivotal Actor on Cancer Stage: When Function Meets Structure2019
Dr Noel Edwards
Dr Catriona Anderson
Dr Mike Althaus
Professor David Thwaites
Trading amino acids at the aphid–Buchnera symbiotic interface2019
Dr Noel Edwards
Dr Catriona Anderson
Nichola Conlon
Andrew Watson
Dr Tim Cheek
et al.
Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters2018
Professor David Thwaites
The Concise Guide to PHARMACOLOGY 2017/18: Overview2017
Dr Noel Edwards
Dr Sarah Rice
Dr Ann Marie Hynes
Dr Shalabh Srivastava
Dr Iain Moore
et al.
A novel LMX1B mutation in a family with end-stage renal disease of ‘unknown cause’2015
Dr Sarah Rice
Dr Noel Edwards
Dr Charlie Tomson
Professor David Thwaites
Professor John Sayer
et al.
Clinical and Genetic Analysis of a Cohort of English Cystinuria Patients2015
Dr Sarah Rice
Dr Noel Edwards
Dr Alice Hartley
Professor David Thwaites
Professor John Sayer
et al.
Clinical and genetic analysis of patients with cystinuria in the UK2015
Dr Ann Marie Hynes
Dr Sarah Rice
Professor David Thwaites
Professor John Sayer
Fourteen Monogenic Genes Account for 15% of Nephrolithiasis/Nephrocalcinosis2015
Dr Sarah Rice
Dr Noel Edwards
Professor John Sayer
Professor David Thwaites
The Effect of a Novel rBAT Mutation on the Expression and Function of System b(o,+)2015
Dr Sarah Rice
Dr Noel Edwards
Professor John Sayer
Professor David Thwaites
The novel rBAT mutation Y579D and activity of the amino acid transporter System b0,+2015
Dr Sarah Rice
Professor David Thwaites
Professor John Sayer
Cystinuria revisited: presentations with calcium-containing stones demands vigilance and screening in the stone clinic2014
Professor David Thwaites
Fishing with flies, worms and bacteria: emerging models for mammalian membrane transport and trafficking2014
Professor David Thwaites
Go with the flow – membrane transport in the gut2013
Nichola Conlon
Dr Noel Edwards
Dr Tim Cheek
Professor David Thwaites
Rheogenic amino acid transport by Drosophila CG4991 of the Amino Acid Auxin Permease (AAAP) transporter family2013
Dr Catriona Anderson
Professor David Thwaites
The Concise Guide to PHARMACOLOGY 2013/14: Overview2013
Professor David Thwaites
News from the dark side!2012
Dr Nia Edwards
Dr Catriona Anderson
Kelly Gatfield
Mark Jevons
Professor David Thwaites
et al.
Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)2011
Professor David Thwaites
Dr Catriona Anderson
The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport2011
Dr Catriona Anderson
Professor David Thwaites
Hijacking solute carriers for proton-coupled drug transport2010
Dr Catriona Anderson
Mark Jevons
Nichola Conlon
Professor David Thwaites
Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine2010
Dr Catriona Anderson
Dr Alison Howard
Professor David Thwaites
Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl--dependent TauT (SLC6A6)2009
Professor David Thwaites
Dr Catriona Anderson
Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A12007
Professor David Thwaites
Dr Catriona Anderson
H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine2007
Dr Catriona Anderson
Professor David Thwaites
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3)2007
Dr Emily Abbot
Danielle Grenade
Dr David Kennedy
Kelly Gatfield
Professor David Thwaites
et al.
Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT12006
Dr David Kennedy
Dr Demetrio Raldua
Professor David Thwaites
Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-22005
Dr Catriona Anderson
Professor David Thwaites
Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)2005
Dr Emily Abbot
Professor David Thwaites
Isolation and function of the amino acid transporter PAT1 (SLC36A1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles2005
Dr David Kennedy
Kelly Gatfield
Dr John Winpenny
Professor David Thwaites
Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (SLC36A2)2005
Dr Catriona Anderson
Danielle Grenade
Dr Katherine Wake
Dr David Kennedy
Professor Frederick Campbell
et al.
H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat2004
Dr Catriona Anderson
Dr Ma Mendoza-Gomez
Dr David Kennedy
Dr Demetrio Raldua
Professor David Thwaites
et al.
Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2)2003
Dr Catriona Anderson
Dr Katherine Wake
Professor David Thwaites
Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-22003
Dr David Kennedy
Dr Katherine Wake
Professor David Thwaites
Structure, tissue expression pattern, and function of the amino acid transporter rat PAT22003
Dr Catriona Anderson
Professor David Thwaites
Substrate recognition by the mammalian proton-dependent amino acid transporter PAT12003
Professor David Thwaites
Dr David Kennedy
Dr Demetrio Raldua
Dr Catriona Anderson
Dr Ma Mendoza-Gomez
et al.
H+/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na+/H+ exchanger2002
Dr David Kennedy
Professor David Thwaites
Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity2002
Dr David Kennedy
Professor David Thwaites
Optimal dipeptide uptake across the apical membrane of human intestinal Caco-2 cell monolayers is dependent on functional NHE3 activity2002
Professor David Thwaites
Professor Nicholas Simmons
Expression and role of sodium, potassium, chloride cotransport (NKCC1) in mouse inner medullary collecting duct (mIMCD-K2) epithelial cells2001
Lee McCloy
Emeritus Professor Paul Taylor
Professor David Thwaites
Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers2001
Dr Catriona Anderson
Dr Demetrio Raldua
Professor Nicholas Simmons
Professor David Thwaites
pH-dependent forskolin modulation of beta-alanine uptake at the apical surface of Caco-2 cell monolayers2001
Dr David Kennedy
Professor David Thwaites
The selective NHE3 inhibitor S1611 modulates dipeptide transport across human intestinal (Caco-2) cell monolayers2001
Professor David Thwaites
Dr Laura Basterfield
Professor Nicholas Simmons
Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers2000
Professor David Thwaites
Chloride-dependent transport of NH4+ into bee retinal glial cells1999
Professor David Thwaites
Professor Dianne Ford
Dr Michael Glanville
Professor Nicholas Simmons
H+/solute-induced intracellular acidification leads to selective activation of apical Na+/H+ exchange in human intestinal epithelial cells1999
Professor David Thwaites
H+-zwitterionic amino acid symport at the brush-border membrane of human intestinal epithelial (Caco-2) cells1999
Professor Dianne Ford
Professor David Thwaites
Professor Nicholas Simmons
Emeritus Professor Harry Gilbert
Emeritus Professor Barry Hirst
et al.
Substrate upregulation of the human small intestinal peptide transporter, hPepT11998
Professor David Thwaites
H+/amino acid symport in intestinal epithelia1997
Professor David Thwaites
Professor Nicholas Simmons
Na+-independent lysine transport in human intestinal Caco-2 cells1996
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells1995
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
D-Cycloserine transport in human intestinal epithelial (Caco-2) cells is mediated by a H+-coupled amino acid transporter1995
Professor David Thwaites
Professor Nicholas Simmons
H+/di-tripeptide transporter (PepT1) expression in the rabbit intestine1995
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
H+-coupled alpha-methylaminoisobutyric acid transport in human intestinal Caco-2 cells1995
Professor David Thwaites
Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter1995
Professor David Thwaites
Professor Nicholas Simmons
The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers1995
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
H+-coupled solute transport in cultured intestinal epithelia1994
Professor David Thwaites
Dr Colin Brown
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
L-Alanine absorption in human intestinal cells driven by the proton electrochemical gradient1994
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H+-coupled absorption1994
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Direct assessment of dipeptide/H+ symport in intact human intestinal (Caco-2) epithelium: a novel method utilising continuous intracellular pH measurement1993
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
H+-coupled (Na+-independent) proline transport in human intestinal (Caco-2) epithelial cell monolayers1993
Professor David Thwaites
Dr Colin Brown
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics1993
Professor David Thwaites
Dr Colin Brown
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Na+-independent, H+-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers1993
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Passive transepithelial absorption of thyrotropin-releasing hormone (TRH) via a paracellular route in cultured intestinal and renal epithelial cell lines1993
Professor David Thwaites
Professor Nicholas Simmons
Emeritus Professor Barry Hirst
Thyrotropin-releasing hormone (TRH) uptake in intestinal brush-border membrane vesicles: comparison with proton-coupled dipeptide and Na+-coupled glucose transport1993
Professor David Thwaites
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic1993
Professor David Thwaites
Dr Colin Brown
Emeritus Professor Barry Hirst
Professor Nicholas Simmons
Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H+-coupled carriers at both apical and basal membranes1993
Professor David Thwaites
The isolation and chemical characterization of a novel vasoactive intestinal peptide-related peptide from a teleost fish, the cod, Gadus morhua1989
Professor David Thwaites
Vasoactive intestinal polypeptide and its relatives: biochemistry, distribution, and functions1989
Professor David Thwaites
Amino acid sequence of a biologically active vasoactive intestinal peptide from the elasmobranch Scyliorhinus canicula1988
Professor David Thwaites
A novel vasoactive intestinal peptide (VIP) from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors1987