Toggle Main Menu Toggle Search

Open Access padlockePrints

Browsing publications by Professor Helen Arthur.

Newcastle AuthorsTitleYearFull text
Dr Esha Singh
Dr Helen Phillips
Professor Helen Arthur
Dynamic changes in endoglin expression in the developing mouse heart2021
Nina Jordan
Dr Sam Tingle
Victoria Shuttleworth
Katie Cooke
Dr Rachael Redgrave
et al.
MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis2021
Dr Sarah Marsh
Dr Catherine Park
Dr Rachael Redgrave
Dr Esha Singh
Lilia Draganova
et al.
Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury2021
Dr Esha Singh
Dr Rachael Redgrave
Dr Helen Phillips
Professor Helen Arthur
Arterial endoglin does not protect against arteriovenous malformations2020
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Pawel Palmowski
Dr Simon Tual-Chalot
et al.
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery2020
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Dr Gavin Richardson
Lilia Draganova
Dr Rachael Redgrave
et al.
CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians2020
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Dr Esha Singh
Dr Benjamin Davison
Dr Catherine Park
et al.
Loss of endothelial Endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signalling2020
Professor Helen Arthur
Oncogenes in brain arteriovenous malformations2020
Professor Helen Arthur
Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia2020
Dr Catherine Park
Dr Suzanne Cormack
Dr Stephen Boag
Dr Karim Bennaceur
Dr Gavin Richardson
et al.
Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction2020
Emily Dookun
Dr Joao Passos
Professor Helen Arthur
Dr Gavin Richardson
Therapeutic Potential of Senolytics in Cardiovascular Disease2020
Dr Kate Bailey
Dr Guy MacGowan
Dr Simon Tual-Chalot
Lauren Charlotte Phillips Phillips
Professor Deborah Henderson
et al.
Disruption of embryonic ROCK signalling reproduces the sarcomeric phenotype of Hypertrophic Cardiomyopathy2019
Rhys Anderson
Anthony Lagnado
Damien Maggiorani
Dr Anna Walaszczyk
Emily Dookun
et al.
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence2019
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury2019
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Professor Ioakim Spyridopoulos
et al.
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.2019
Dr Rachael Redgrave
Professor Helen Arthur
Role of soluble endoglin in BMP9 signaling2019
Oliver Yausep
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
et al.
The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury2019
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?2018
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.2018
Dr Simon Tual-Chalot
Professor Helen Arthur
Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 22018
Professor Helen Arthur
Executive summary of the 12th HHT international scientific conference2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Rhys Anderson
et al.
Senescence as a therapeutic target for myocardial ageing2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes age related cardiac dysfunction2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice.2018
Eunate Gallardo Vara
Dr Simon Tual-Chalot
Professor Helen Arthur
Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia2018
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Dr Benjamin Davison
Dr Esha Singh
Dr Darroch Hall
et al.
Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis2017
Professor Helen Arthur
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling2017
Professor Helen Arthur
Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction2017
Professor Ioakim Spyridopoulos
Professor Helen Arthur
Microvessels of the heart: Formation, regeneration and dysfunction2017
Dr Sarah Marsh
Professor Helen Arthur
Professor Ioakim Spyridopoulos
The secret life of nonclassical monocytes2017
Professor Helen Arthur
Endoglin is required in Pax3-derived cells for embryonic blood vessel formation2016
Professor Helen Arthur
Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations2016
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Professor Helen Arthur
Loss of Endothelial Endoglin Leads to Heart Failure2016
Professor Helen Arthur
Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response2016
Dr Marwa Mahmoud
Professor Helen Arthur
Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function2016
Professor Helen Arthur
Persistent infiltration and pro-inflammatory differentiation of monocytes causing unresolved inflammation in brain arteriovenous malformation2016
Professor Bob Anderson
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Rebecca Dodds
Dr Andrew Owens
et al.
The role of cardiomyocyte senescence and regeneration in Ageing2016
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Dr Benjamin Davison
Liz Greally
Dr Mauro Santibanez Koref
et al.
Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction2016
Dr Simon Tual-Chalot
Dr Benjamin Davison
Dr Rachael Redgrave
Professor Helen Arthur
Endoglin is required to maintain normal cardiac function in adult life2015
Professor Helen Arthur
Executive summary of the 11th HHT international scientific conference2015
Dr Simon Tual-Chalot
Professor Helen Arthur
Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges2015
Professor Helen Arthur
Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models-Brief Report2014
Professor Helen Arthur
ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis2014
Dr Simon Tual-Chalot
Dr Marwa Mahmoud
Kathleen Allinson
Dr Rachael Redgrave
Professor Helen Arthur
et al.
Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression2014
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Professor Helen Arthur
Endothelial expression of endoglin and Acvrl1 are required for normal vascular patterning during developmental angiogenesis and for maintaining adult vessel integrity2014
Sarah Thompson
Dr Rachael Redgrave
Professor John Kirby
Professor Helen Arthur
Professor Simi Ali
et al.
Modulation of wound healing post-myocardial infarction2014
Professor Helen Arthur
Novel Brain Arteriovenous Malformation Mouse Models for Type 1 Hereditary Hemorrhagic Telangiectasia2014
Dr Jason Zhai
Ross Cordiner
Professor Helen Arthur
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination2013
Dr Jason Zhai
Professor Helen Arthur
LRG1 promotes angiogenesis by modulating endothelial TGFß signalling2013
Dr Ingrid Ehrmann
Caroline Dalgliesh
Dr Marina Danilenko
Moira Crosier
Lynne Overman
et al.
The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain2013
Dr Simon Tual-Chalot
Kathleen Allinson
Professor Helen Arthur
Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo2013
Dr Sarah Watkins
Dr Gillian Borthwick
Rachael Oakenfull
Dr Andrew Robson
Professor Helen Arthur
et al.
Angiotensin II-induced cardiomyocyte hypertrophy in vitro is TAK1-dependent and Smad2/3-independent2012
Dr Rachael Redgrave
Dr Benjamin Davison
Dr Muhammad Amirrasouli
Professor Bernard Keavney
Professor Andrew Blamire
et al.
Cardiosphere-Derived Cell Transplantation Rescues Cardiac Function Post-MI Independently of Endoglin Expression2012
Kathleen Allinson
Professor Helen Arthur
Endothelial Expression of TGF beta Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System2012
Professor Helen Arthur
Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse2012
Dr Elise Glen
Dr Ana Topf
Dr Darroch Hall
Dr John O'Sullivan
Linda Sneddon
et al.
Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation2012
Dr Marwa Mahmoud
Professor Helen Arthur
Angiogenesis Regulation by TGFbeta signalling: clues from an inherited vascular disease2011
Dr Benjamin Davison
Dr Rachael Redgrave
Professor Bernard Keavney
Professor Andrew Blamire
Professor Helen Arthur
et al.
In vivo depletion of endoglin results in significant left ventricular remodelling2011
Dr Elise Glen
Dr Ana Topf
Dr Darroch Hall
Dr John O'Sullivan
Linda Sneddon
et al.
Non-synonymous SMAD6 mutations impaired inhibition of BMP signalling in patients with congenital cardiovascular malformation2011
Professor Helen Arthur
Dr Simon Bamforth
TGF beta Signaling and Congenital Heart Disease: Insights from Mouse Studies2011
Dr Sarah Watkins
Dr Gillian Borthwick
Professor Helen Arthur
The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro2011
Professor Helen Arthur
VEGF Induced More Severe Cerebrovascular Dysplasia in the Adult Mouse Brain with Regional Deletion of Alk1 Compared to Endoglin2011
Dr Marwa Mahmoud
Kathleen Allinson
Dr Jason Zhai
Rachael Oakenfull
Professor Helen Arthur
et al.
Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin2010
Professor Helen Arthur
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia2010
Dr Andrew Robson
Kathleen Allinson
Professor Bob Anderson
Professor Deborah Henderson
Professor Helen Arthur
et al.
The TGF beta Type II Receptor Plays a Critical Role in the Endothelial Cells During Cardiac Development2010
Dr Honey Thomas
Professor John Dark
Professor Helen Arthur
Professor Bernard Keavney
Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients2009
Dr Marwa Mahmoud
Dr Gillian Borthwick
Professor Helen Arthur
Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH2009
Dr Honey Thomas
Dr Peter Avery
Dr Javed Ahmed
Dr Richard Edwards
Professor Azfar Zaman
et al.
Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis2009
Dr Rachael Redgrave
Dr Michael Cunnington
Dr Peter Avery
Professor Bernard Keavney
Professor Helen Arthur
et al.
Circulating endothelial progenitor cells exhibit diurnal variation2008
Dr Rachael Redgrave
Dr Michael Cunnington
Professor Bernard Keavney
Professor Helen Arthur
Circulating endothelial progenitor cells from healthy individuals exhibit diurnal variation2008
Dr Honey Thomas
Professor Helen Arthur
Professor Bernard Keavney
Investigation of relationships between circulating endothelial progenitor cell numbers, cardiac allograft vasculopathy and donor heart age in cardiac transplant recipients2008
Professor Helen Arthur
Extracellular control of TGFβ signalling in vascular development and disease2007
Kathleen Allinson
Professor Helen Arthur
Generation of a floxed allele of the mouse endoglin gene2007
Dr Sarah Watkins
Dr Leon Jonker
Professor Helen Arthur
A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy2006
Professor Helen Arthur
Endoglin has a crucial role in blood cell-mediated vascular repair2006
Dr Gillian Borthwick
Dr Sarah Johnson
Professor Sir John Burn
Professor Helen Arthur
Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism2006
Professor Helen Arthur
TGF-beta in endothelial cell function and vascular development2005
Dr Sarah Watkins
Dr Leon Jonker
Professor Helen Arthur
TGFbeta typeII receptor interacts with TGFbeta activated kinase (TAK1): Implications for controlling cardiac hypertrophy2005
Dr Sarah Johnson
Professor Helen Arthur
Professor Sir John Burn
Bowel cancer prevention: Aspirin induces Cox-2 independent endothelial cell apoptosis facilitating angiogenesis arrest2004
Dr Leon Jonker
Professor Helen Arthur
Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: A paradigm for hereditary haemorrhagic telangiectasia2004
Dr Leon Jonker
Professor Helen Arthur
Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction2004
Professor Helen Arthur
Vascular Endothelial Growth Factor Induces Abnormal Microvasculature in the Endoglin Heterozygous Mouse Brain2004
Sanjay Chaudhri
Professor Helen Arthur
Dr Mark Bennett
Alan Horgan
Angiogenesis in rectal cancer: Can preoperative endoscopic biopsies predict tumour behaviour?2003
Professor Helen Arthur
Investigation of TGF-beta plasma levels as a modifier of the phenotype of hereditary hemorrhagic telangiectasia2003
Evelyn Torsney
Dr Richard Charlton
Professor Sir John Burn
Professor Helen Arthur
Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality2003
Professor Helen Arthur
Professor Sir John Burn
Ronald Wilson
Non steroidal anti-inflammatory drugs and colorectal cancer prevention: Evidence for a cox-2 independent anti-angiogenic effect2003
Dr Christopher Kettle
Dr Trevor Jowett
Professor Helen Arthur
The pattern of segment formation, as revealed by engrailed expression, in a centipede with a variable number of segments2003
Professor Helen Arthur
Evelyn Torsney
Professor Sir John Burn
The role of endoglin in cardiovascular development2003
Dr Leon Jonker
Professor Helen Arthur
Endoglin expression in early development is associated with vasculogenesis and angiogenesis2002
Evelyn Torsney
Dr Richard Charlton
Professor Helen Arthur
Inducible expression of human endoglin during inflammation and wound healing in vivo2002
Evelyn Torsney
Dr Richard Charlton
Professor Helen Arthur
Endoglin, a gene required for murine embryonic vasculogenesis, is upregulated in angiogenesis in human inflammatory disease: Studies using a 'knockout' mouse model (the 'Cookson Mouse')2001
Evelyn Torsney
Dr Richard Charlton
Professor Helen Arthur
An antibody to Endoglin/CD105 (SN6h): A marker for endothelial cells in chronic inflammatory disease2000
Professor Helen Arthur
Glenn Renforth
Dr David Wilson
Evelyn Torsney
Dr Trevor Jowett
et al.
Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development2000
Professor Helen Arthur
Dr David Wilson
Evelyn Torsney
Glenn Renforth
Professor Sir John Burn
et al.
Progress towards developing a mouse model of Hereditary Haemorrhagic Telangiectasia1999