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Browsing publications by Emeritus Professor Herbie Newell

Newcastle AuthorsTitleYearFull text
Christopher Coxon
Dr Ian Hardcastle
Dr Suzannah Harnor
Emeritus Professor Herbie Newell
Dr Mangaleswaran Sivaprakasam
et al.
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase2020
Emeritus Professor Herbie Newell
A successful collaboration between academia, biotech and pharma led to discovery of erdafitinib, a selective FGFR inhibitor recently approved by the FDA2019
Liz Matheson
Huw Thomas
Marian Case
Dr Helen Blair
Dr Dino Masic
et al.
Glucocorticoids and selumetinib are highly synergistic in RAS pathway mutated childhood acute lymphoblastic leukemia through upregulation of BIM2019
Stephanie Myers
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
Dr Tim Blackburn
et al.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
Philip Berry
Dr Jennifer Bonner
Calum Kirk
Huw Thomas
Professor John Lunec
et al.
Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma2019
Huw Thomas
Dr Elaine Willmore
Dr Anita Wittner
Nicole Phillips
Dr Susan Tudhope
et al.
Selective DNA-PKcs Inhibition Extends the Therapeutic Index of Localized Radiotherapy and Chemotherapy2019
Honorine Lebraud
Dr Richard Noble
Nicole Phillips
Emeritus Professor Herbie Newell
Professor John Lunec
et al.
A highly potent clickable probe for cellular imaging of MDM2 and assessing dynamic responses to MDM2-p53 inhibition2018
Christopher Coxon
Dr Suzannah Harnor
Dr Mathew Martin
Professor Bernard Golding
Dr Ian Hardcastle
et al.
Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines2017
Emeritus Professor Herbie Newell
Discovery & pharmacological characterization of JNJ-42756493 (Erdafitinib), a functionally selective small-molecule FGFR family inhibitor2017
Philip Berry
Dr Jennifer Bonner
Professor John Lunec
Emeritus Professor Herbie Newell
In vivo evaluation of the intravenous MDM2-p53 antagonist RO6839921 alone and in combination with temozolomide in TP53 wild-type orthotopic models of neuroblastoma2017
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