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Two families with the Li-Fraumeni cancer family syndrome

Lookup NU author(s): Professor Andrew Pearson, Emeritus Professor Alan Craft


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The first two families to be identified in the United Kingdom with the Li-Fraumeni syndrome of familial cancer are reported. The first family comprises breast carcinoma in the mother and adrenocortical carcinoma, medulloblastoma, and rhabdomyosarcoma in three of her four children, and the second family comprises breast carcinoma in the mother and adrenocortical carcinoma and rhabdomyosacrcoma in two of her three children. All three of the surviving children with malignancy, and one other who has recently died, possess the tissue type antigen B12.

Publication metadata

Author(s): Pearson, A. D. J., Craft, A. W., Ratcliffe, J. M., Birch, J. M., Morris-Jones, P., Roberts, D. F.

Publication type: Article

Publication status: Published

Journal: Journal of Medical Genetics

Year: 1982

Volume: 19

Issue: 5

Pages: 362-365

Print publication date: 01/10/1982

ISSN (print): 0022-2593

ISSN (electronic): 1468-6244


DOI: 10.1136/jmg.19.5.362

PubMed id: 6958872


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