Toggle Main Menu Toggle Search

Open Access padlockePrints

Role of infection in the death of children with acute lymphoblastic leukaemia

Lookup NU author(s): Emeritus Professor Alan Craft, Dr Michael Reid, Dr Jennifer Kernahan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Twenty-four consecutive deaths from a total of 70 children receiving treatment for acute lymphoblastic leukaemia (ALL) have been reviewed. An attempt has been made to ascribe the cause of death to either infection, haemorrhage, the leukaemia itself, or a combination of these factors. No child was free of infection at death. Infection, with or without haemorrhage, was responsible for the deaths of all 15 children whose leukaemia had not relapsed. Although infection was present at death in all 9 children whose leukaemia had relapsed, the leukaemia process itself was also a major contributing factor. Viruses were associated with death in many of the children and may be emerging as important pathogens in children with ALL. Familiarity with a protocol may be an important factor in the prevention of fatal infections in such children. Centralization of treatment is necessary if this expertise is to be acquired.

Publication metadata

Author(s): Craft, A. W., Reid, M. M., Bruce, E., Kernahan, J., Gardner, P. S.

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 1977

Volume: 52

Issue: 10

Pages: 752-757

Print publication date: 01/10/1977

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044


DOI: 10.1136/adc.52.10.752

PubMed id: 270964


Altmetrics provided by Altmetric