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Small intestinal transit time affects methotrexate absorption in children with acute lymphoblastic leukemia

Lookup NU author(s): Professor Andrew Pearson, Emeritus Professor Alan Craft


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Serum methotrexate concentrations have been measured in 28 children with acute lymphoblastic leukaemia (ALL) following PO administration under standard conditions. Small-intestinal transit time, measured by the time taken for lactulose to pass from mouth to caecum, has been related with methotrexate absorption parameters. Small intestinal transit times ranged from 30 to 240 min. Children with longer transit times had later times of peak methotrexate concentration and tended to have a more erratic methotrexate absorption profile with two peaks. There appears to be an optimal transit time between 90 and 105 min for methotrexate absorption, with both faster and slower small-intestinal transit times producing lower peak concentrations as a fraction of the dose.

Publication metadata

Author(s): Pearson, A. D. J., Craft, A. W., Eastham, E. J., Aherne, G. W., Littleton, P., Pearson, G. L., Campbell, A. N.

Publication type: Article

Publication status: Published

Journal: Cancer Chemotherapy and Pharmacology

Year: 1985

Volume: 14

Issue: 3

Pages: 211-215

Print publication date: 01/04/1985

ISSN (print): 0344-5704

ISSN (electronic): 1432-0843


DOI: 10.1007/BF00258118

PubMed id: 3858014


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