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Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia

Lookup NU author(s): Emeritus Professor Alan Craft, Dr Michael Reid

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Abstract

Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.

Publication metadata

Author(s): Chang, J., Craft, A. W., Reid, M. M., Coutinho, L. H., Dexter, M.

Publication type: Article

Publication status: Published

Journal: American Journal of Hematology

Year: 1990

Volume: 35

Issue: 2

Pages: 125-126

Print publication date: 01/10/1990

ISSN (print): 0361-8609

ISSN (electronic): 1096-8652

URL: http://dx.doi.org/10.1002/ajh.2830350212

DOI: 10.1002/ajh.2830350212

PubMed id: 1698019

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