Node negative breast cancer: the prognostic value of DNA ploidy for long-term survival
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Lookup NU author(s): Dr Ian Corbett,
Dr Brian Shenton,
Professor Thomas Lennard
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The DNA content of breast tumours from 170 patients who presented between 1978 and 1980 was measured by flow cytometry. The relationship between tumour ploidy and disease outcome was assessed and its association with other prognostic factors evaluated. Compared with those with diploid tumours, patients with aneuploid tumours had significantly earlier relapse and shorter survival (P < 0.0001). Tumour ploidy was strongly related to grade (P < 0.001), but there was no significant association between DNA ploidy and c-erb-B-2 expression, lymph node status or tumour size. In lymph node negative and c-erb-B-2 negative patients, aneuploid tumours were associated with a poorer prognosis (P < 0.001) than diploid tumours. Multivariate analysis showed that tumour ploidy gave independent information on disease free and overall survival. Tumour ploidy may be used as an independent prognostic variable in patients with breast cancer and it may be helpful in defining patients within the node negative or c-erb-B-2 negative groups likely to have a poor outcome who might benefit from adjuvant treatment.
Author(s): Yuan J, Hennessy C, Corbett IP, Dykin R, Givan AL, Shenton BK, Henry JA, Wright C, Lennard TWJ
Publication type: Article
Publication status: Published
Journal: British Journal of Surgery
Print publication date: 01/07/1991
ISSN (print): 0007-1323
ISSN (electronic): 1365-2168
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