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Lookup NU author(s): Dr Nicholas Bown,
Dr Michael Reid,
Professor Andrew Pearson,
Professor Archibald Malcolm,
Emeritus Professor Alan Craft
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In a patient with stage IV disseminated neuroblastoma treated by chemotherapy extensive cytogenetic investigations were performed on the residual primary tumour and bone marrow immediately before myeloablative treatment and autologous marrow rescue. Two abnormal clones both showing lp+, a characteristic abnormality of neuroblastoma, were detected in cells from the residual primary tumour, providing direct evidence of persisting viable tumour. Such investigations should be a routine part of the assessment of response to treatment in patients with neuroblastoma, and could be extended to others in whom "second look" surgery is performed.
Author(s): Bown, N. P., Reid, M. M., Pearson, A. D. J., Daviaon, E. V., Malcolm, A. J., Craft, A. W.
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Pathology
Print publication date: 01/11/1987
ISSN (print): 0021-9746
ISSN (electronic): 1472-4146
PubMed id: 3693571
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