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Cytogenic investigations in the assessment of response to treatment in neuroblastoma

Lookup NU author(s): Dr Nicholas Bown, Dr Michael Reid, Professor Andrew Pearson, Professor Archibald Malcolm, Emeritus Professor Alan Craft


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In a patient with stage IV disseminated neuroblastoma treated by chemotherapy extensive cytogenetic investigations were performed on the residual primary tumour and bone marrow immediately before myeloablative treatment and autologous marrow rescue. Two abnormal clones both showing lp+, a characteristic abnormality of neuroblastoma, were detected in cells from the residual primary tumour, providing direct evidence of persisting viable tumour. Such investigations should be a routine part of the assessment of response to treatment in patients with neuroblastoma, and could be extended to others in whom "second look" surgery is performed.

Publication metadata

Author(s): Bown, N. P., Reid, M. M., Pearson, A. D. J., Daviaon, E. V., Malcolm, A. J., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 1987

Volume: 40

Issue: 11

Pages: 1334-1336

Print publication date: 01/11/1987

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146


DOI: 10.1136/jcp.40.11.1334

PubMed id: 3693571


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