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Intestinal permeability during chemotherapy for childhood tumours

Lookup NU author(s): Professor Andrew Pearson, Emeritus Professor Alan Craft, Dr Michael Laker


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The intestinal permeability to mannitol and lactulose was measured in 29 children receiving treatment for solid tumours. At the time of study they had no gastrointestinal symptoms and appeared clinically well. However, there was a significant reduction in the absorption of mannitol when compared to normal children. This small bowel dysfunction may result in malabsorption of nutrients and drugs. There was a significant correlation between decreased mannitol absorption and low nutritional status.

Publication metadata

Author(s): Pledger, J. V., Pearson, A. D. J., Craft, A. W., Laker, M. F., Eastham, E. J.

Publication type: Article

Publication status: Published

Journal: European Journal of Pediatrics

Year: 1988

Volume: 147

Issue: 2

Pages: 123-127

Print publication date: 01/02/1988

ISSN (print): 0340-6199

ISSN (electronic): 1432-1076


DOI: 10.1007/BF00442208

PubMed id: 3130249


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