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Adenosine-diphosphoribosyltransferase inhibitors can protect against or potentiate the cytotoxicity of S-phase acting drugs

Lookup NU author(s): Professor barbara Durkacz

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Abstract

We have investigated the effect of inhibitors of ADP-ribosyltransferase on the cytotoxicity of a range of S-phase acting drugs. Co-administration of 3 mM 3-aminobenzamide (3AB) potentiated the cytotoxicity of TG 2-fold, but had no effect on the cytotoxicity of HU, FdUrd or araC. Higher concentrations of benzamides (e.g. 10-20 mM 3AB) produced a G1-specific cell cycle blockade. This treatment prevented cells entering S-phase DNA synthesis and consequently protected against the cytotoxicity of the same S-phase acting drugs. Thus, using different treatment regimens with 3AB, it was possible to either potentiate or protect against the cytotoxicity of TG.

Publication metadata

Author(s): Moses K, Harris AL, Durkacz BW

Publication type: Article

Publication status: Published

Journal: Biochemical Pharmacology

Year: 1988

Volume: 37

Issue: 11

Pages: 2155-2160

ISSN (print): 0006-2952

ISSN (electronic): 1873-2968

URL: http://dx.doi.org/10.1016/0006-2952(88)90575-8

DOI: 10.1016/0006-2952(88)90575-8

PubMed id: 3132171

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