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Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases

Lookup NU author(s): Emeritus Professor Nicol Ferrier, Dr Christopher Morris, Dr Arjun Sahgal, Professor Ian McKeith, Professor Jim Edwardson, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry


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The binding of the selective 5-HT2 antagonist [H-3]ketanserin has been investigated in the temporal cortex of patients with Alzheimer's disease (SDAT), Parkinson's disease (PD), senile dementia of Lewy body type (SDLT) and neuropathologically normal subjects (control). 5-HT2 binding was reduced in SDAT, PD with dementia and SDLT. SDAT showed a 5-HT2 receptor deficit across most of the cortical layers. A significant decrease in 5-HT2 binding in the deep cortical layers was found in those SDLT cases without hallucinations. SDLT cases with hallucinations only showed a deficit in one upper layer. There was a significant difference in cortical layers III and V between SDLT without hallucinations and SDLT with hallucinations. The results confirm an abnormality of serotonin binding in various forms of dementia and suggest that preservation of 5-HT2 receptor in the temporal cortex may differentiate hallucinating from non-hallucinating cases of SDLT.

Publication metadata

Author(s): Cheng AVT, Ferrier IN, Morris CM, Jabeen S, Sahgal A, McKeith IG, Edwardson JA, Perry RH, Perry EK

Publication type: Article

Publication status: Published

Journal: Journal of the Neurological Sciences

Year: 1991

Volume: 106

Issue: 1

Pages: 50-55

Print publication date: 01/11/1991

ISSN (print): 0022-510X

ISSN (electronic): 1878-5883

Publisher: Elsevier BV


DOI: 10.1016/0022-510X(91)90193-B


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