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Quantification of βA4 protein deposition in the medial temporal lobe: A comparison of Alzheimer's disease and senile dementia of the Lewy body type

Lookup NU author(s): Emeritus Professor Robert Perry


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The distribution of beta-amyloid protein (beta-A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n=13), senile dementia of Lewy body type (SDLT) (n=12) and age matched controls (n=9). Using a previously described image analysis technique the extent of beta-A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta-A4 in the areas sampled and both contained significantly more beta-A4 than the age matched controls. particularly in the dentate and parahippocampal gyri. The similarity of the beta-A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta-A4 precursor protein.

Publication metadata

Author(s): Gentleman SM, Williams B, Royston MC, Jagoe R, Clinton J, Perry RH, Ince PG, Allsop D, Polak JM, Roberts GW

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1992

Volume: 142

Issue: 1

Pages: 9-12

Print publication date: 01/08/1992

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd.


DOI: 10.1016/0304-3940(92)90608-A


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