Toggle Main Menu Toggle Search

Open Access padlockePrints

Bombesin and gastrin-releasing peptide stimulate electrogenic ion transport in cultured human endometrial epithelial cell layers

Lookup NU author(s): Dr Caroline Matthews, Dr Chris RedfernORCiD, Emeritus Professor Barry Hirst


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Electrogenic ion transport across human endometrial epithelial cells grown as polarized monolayers on permeable supports was measured as an inward short-circuit current (I(SC); 16.2+/-1.1 muA/cm2). Bombesin (10(-7) m) and human gastrin-releasing peptide (GRP; 10(-7) M) caused transient enhancement of this I(SC). These effects were largely restricted to the basolateral surface of the cells; responses to apical peptide were modest in comparison with those to basolateral peptide. GRP and other bombesin-related peptides may have a role in regulation of endometrial epithelial ion transport in vivo and thereby influence the intra-uterine environment.

Publication metadata

Author(s): Matthews CJ, Redfern CPF, Thomas EJ, Hirst BH

Publication type: Article

Publication status: Published

Journal: Experimental Physiology

Year: 1993

Volume: 78

Issue: 5

Pages: 715-718

Print publication date: 01/09/1993

ISSN (print):

ISSN (electronic):