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Possible regulation of soluble ICAM-1 levels by interleukin-1 in a subset of breast cysts
Lookup NU author(s): Professor Thomas Lennard
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There are 2 main groups of breast cysts characterized by their intracystic sodium-to-potassium ratios. Women who have intracystic Na/K < 3 may have a higher risk of developing breast cancer than those who have intracystic Na/K > 3. The cell adhesion molecule, ICAM-I, has been shown to be inducible by interleukin-I (IL-I). Furthermore, ICAM-I may be involved in the progression of metastasis in certain malignancies. The aim of this study was to measure intracystic soluble ICAM-I (sICAM-I) and IL-I alpha/beta levels and to assess the relationships between these substances. Wide-ranging concentrations of sICAM-I, IL-Ialpha and IL-Ibeta were found in breast-cyst fluid. The high-electrolyte-ratio group had intracystic levels of sICAM-I and IL-Ibeta which were significantly higher than those of the low-electrolyte-ratio group. No significant difference was found between IL-Ialpha concentrations in the 2 groups of breast cysts. Strong positive correlations were found between sICAM-I and IL-Ialpha, sICAM-I and IL-Ibeta, and IL-Ialpha and IL-Ibeta. The significance of the higher concentrations of sICAM-I in the high-electrolyte-ratio group remains to be determined, but the results of this study suggest that sICAM-I levels in the high-electrolyte-ratio group may be regulated in part by IL-Ialpha and IL-Ibeta (C) 1993 Wiley-Liss, Inc.
Author(s): Lai LC, Kadory S, Cornell C, Lennard TWJ
Publication type: Article
Publication status: Published
Journal: International Journal of Cancer
Year: 1993
Volume: 55
Issue: 4
Pages: 586-589
Print publication date: 01/10/1993
ISSN (print): 0960-7404
ISSN (electronic): 1879-3320
URL: http://dx.doi.org/10.1002/ijc.2910550412
DOI: 10.1002/ijc.2910550412
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