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Chromosome 22 abnormalities in Ewing's sarcoma

Lookup NU author(s): Professor Andrew Pearson, John Emslie, Dr Michael Reid, Professor Archibald Malcolm, Emeritus Professor Alan Craft


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A child with disseminated Ewing's sarcoma underwent cytogenetic investigations which showed different structural rearrangements of chromosome 22 at diagnosis (?ring22), and at relapse [t(10;22)], but the classic translocation t(11;22) was not detectable. This case provides further evidence of the importance of chromosome 22 in this disease, while raising some questions about the central importance of the translocation between chromosomes 11 and 22.

Publication metadata

Author(s): Davison, E. V., Pearson, A. D. J., Emslie, J. B., Reid, M. M., Malcolm, A. J., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 1989

Volume: 42

Issue: 8

Pages: 797-799

Print publication date: 01/08/1989

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146


DOI: 10.1136/jcp.42.8.797

PubMed id: 2768519


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