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Intestinal permeability in Crohn's disease

Lookup NU author(s): Dr Robert Nelson, Professor Andrew Pearson, Dr Mike Laker


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Crohn's disease may present insidiously, especially in childhood, and diagnosis may be delayed. In addition, the clinical assessment of the extent of disease activity may be inaccurate. Using mannitol and lactulose as probe molecules we have carried out a cross sectional study of intestinal permeability in patients with active Crohn's disease (n = 17) and control subjects (n = 31). Activity was assessed by an activity index score. The lactulose:mannitol urinary excretion ratio was significantly increased in Crohn's disease. Overall sensitivity was 82%, and 92% when activity was moderate or severe. When permeability was compared with the activity index there was a significant correlation among patients. In five patients studied longitudinally a significant correlation was also present. Measurement of intestinal permeability is non-invasive, and may be useful both as a screening test in patients with non-specific symptoms, and for the assessment of the extent of disease activity in patients with Crohn's disease.

Publication metadata

Author(s): Murphy MS, Eastham EJ, Nelson R, Pearson ADJ, Laker MF

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 1989

Volume: 64

Issue: 3

Pages: 321-325

Print publication date: 01/03/1989

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044


DOI: 10.1136/adc.64.3.321

PubMed id: 2495775


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