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Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia

Lookup NU author(s): Emeritus Professor Alan Craft, Dr Jennifer Kernahan


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Gonadal function was assessed in 15 boys with acute lymphoblastic leukaemia (ALL) who had received testicular irradiation. The dose to the testes was 12 Gy in 12, 15 Gy in 1, and 24 Gy in 2 cases. All of those who had received 12 or 15 Gy had normal Leydig cell function, although high levels of gonadotropins suggest subclinical Leydig cell damage. The 2 who had 24 Gy had Leydig cell failure. All who were old enough to produce a semen specimen were azoospermic.

Publication metadata

Author(s): Castillo, L. A., Craft, A. W., Kernahan, J., Evans, R. G. B., Aynsley-Green, A.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 1990

Volume: 18

Issue: 3

Pages: 185-189

ISSN (print): 0098-1532

ISSN (electronic): 1545-5017


DOI: 10.1002/mpo.2950180304

PubMed id: 2109822


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