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Lookup NU author(s): Emeritus Professor Elaine Perry,
Emeritus Professor Robert Perry,
Dr Elizabeth Marshall
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The overactivity of glutamatergic neurons may underlie some neurodegenerative disorders, including Alzheimer's disease (AD). We explored the relationship between glutamatergic transmission and neurofibrillary tangle formation by measuring [H3]-D-aspartate binding activity and the proportion of neurons containing tangles within individual thalamic nuclei in five AD cases. Five elderly normal and five Parkinson's disease (PD) cases were used as controls. A highly significant correlation between [H-3]-D-aspartate binding and tangle counts in Alzheimer's disease suggests that those thalamic nuclei which normally receive a relatively dense glutamatergic afferent imput are predisposed to tangle formation. There were no significant differences in individuals thalamic nuclear [H-3]-D-aspartate binding between controls and the AD and PD groups.
Author(s): Xuereb JH, Candy JM, Perry EK, Perry RH, Marshall E, Bonham JR
Publication type: Article
Publication status: Published
Journal: Neuropathology and Applied Neurobiology
Print publication date: 01/12/1990
Online publication date: 12/05/2008
ISSN (print): 0305-1846
ISSN (electronic): 1365-2990
Publisher: Wiley-Blackwell Publishing Ltd.
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