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Distribution of neurofibrillary tangle formation and [³H]-D-aspartate receptor binding in the thalamus in the normal elderly brain, in Alzheimer's disease and in Parkinson's disease

Lookup NU author(s): Emeritus Professor Elaine Perry, Emeritus Professor Robert Perry, Dr Elizabeth Marshall

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Abstract

The overactivity of glutamatergic neurons may underlie some neurodegenerative disorders, including Alzheimer's disease (AD). We explored the relationship between glutamatergic transmission and neurofibrillary tangle formation by measuring [H3]-D-aspartate binding activity and the proportion of neurons containing tangles within individual thalamic nuclei in five AD cases. Five elderly normal and five Parkinson's disease (PD) cases were used as controls. A highly significant correlation between [H-3]-D-aspartate binding and tangle counts in Alzheimer's disease suggests that those thalamic nuclei which normally receive a relatively dense glutamatergic afferent imput are predisposed to tangle formation. There were no significant differences in individuals thalamic nuclear [H-3]-D-aspartate binding between controls and the AD and PD groups.

Publication metadata

Author(s): Xuereb JH, Candy JM, Perry EK, Perry RH, Marshall E, Bonham JR

Publication type: Article

Publication status: Published

Journal: Neuropathology and Applied Neurobiology

Year: 1990

Volume: 16

Issue: 6

Pages: 477-488

Print publication date: 01/12/1990

Online publication date: 12/05/2008

ISSN (print): 0305-1846

ISSN (electronic): 1365-2990

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2990.1990.tb01287.x

DOI: 10.1111/j.1365-2990.1990.tb01287.x

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