Browse by author
Enteroviruses and idiopathic dilated cardiomyopathy
Lookup NU author(s): Dr Felicity May, Professor John Dark
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Previous studies have suggested that some cases of idiopathic dilated cardiomyopathy (IDC) are due to persistent viral infection following an episode of viral myocarditis. Viral RNA sequences have recently been detected in material from patients with IDC using molecular biological techniques. We tested 40 samples from recipients' hearts explanted at cardiac transplantation for the presence of enteroviral RNA sequences, using a Northern blotting technique. Material from 19 cases of IDC and 21 cases of non-cardiomyopathic cardiac failure was examined together with Coxsackie-virus-infected neonatal mouse heart as a positive control and non-infected adult mouse heart as a negative control. A sharp band of viral RNA was detected in the positive control sample. No hybridization signal attributable to viral RNA was obtained for the negative control or for any of the test samples. We conclude that the role of enteroviruses in the pathogenesis of cardiomyopathy is not fully established and that further study is warranted.
Author(s): Cochrane HR, May FEB, Ashcroft T, Dark JH
Publication type: Article
Publication status: Published
Journal: Journal of Pathology
Year: 1991
Volume: 163
Issue: 2
Pages: 129-131
Print publication date: 01/02/1991
ISSN (print): 0022-3417
ISSN (electronic): 1096-9896
DOI: 10.1002/path.1711630208
Altmetrics provided by Altmetric
