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Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion

Lookup NU author(s): Professor Andrew Pearson, Dr Ian Sharkey, Emeritus Professor Alan Craft


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Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400-mu-g/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.

Publication metadata

Author(s): Kohli-Kumar, M., Pearson, A. D. J., Sharkey, I., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: DICP-The Annals of Pharmacotherapy

Year: 1991

Volume: 25

Issue: 5

Pages: 469-470

Print publication date: 01/05/1991

ISSN (print): 0012-6578

ISSN (electronic): 1542-6270


PubMed id: 2068829