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The biochemical and haemodynamic effects of adrenaline in lignocaine local anaesthetic solutions in patients having third molar surgery under general anaesthesia

Lookup NU author(s): Dr John Meechan


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The effects of adrenaline-containing and adrenaline-free lignocaine local anaesthetic solutions injected in doses consistent with clinical practice on plasma potassium concentration, blood glucose levels and haemodynamic responses were investigated in 20 patients having third molar surgery under general anaesthesia. All patients received a standard general anaesthetic regime. Ten patients were given 4.0 ml of 2% lignocaine as an inferior dental and long buccal block during their general anaesthetic and the other 10 received 4.0 ml of 2% lignocaine containing 1:80000 adrenaline in the same manner. There were no significant differences between treatments in blood pressure or heart rate. However, there were significant differences between treatments in plasma potassium concentration and blood glucose levels.

Publication metadata

Author(s): Meechan JG, Thomson CW, Blair GS, Rawlins MD

Publication type: Article

Publication status: Published

Journal: British Journal of Oral and Maxillofacial Surgery

Year: 1991

Volume: 29

Issue: 4

Pages: 263-268

Print publication date: 01/08/1991

ISSN (print): 0266-4356

ISSN (electronic): 1532-1940

Publisher: Churchill Livingstone


DOI: 10.1016/0266-4356(91)90195-B


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