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¹H NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin

Lookup NU author(s): Professor Herbie Newell

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Abstract

Samples of urine from a patient obtained before and after treatment with 300 mg of the anticancer drug [Pt(II)(NH3)2(CBDCA)] (carboplatin, "Paraplatin", where CBCDA is 1,1-dicarboxycyclobutane) have been analysed using 500 MHz 1D and 2D H-1 NMR spectroscopy. Peaks for the intact drug and the free ligand CBDCA have been assigned and are present in a mol ratio of ca. 5:1. Only about one half of the total Pt in the sample was present as intact drug. Relative to creatinine and citrate, the excretion of hippurate increased by a factor of ca. 4 after drug treatment. This work suggests that NMR spectroscopy can play a valuable role in studies of carboplatin metabolism.

Publication metadata

Author(s): Ranford JD, Sadler PJ, Balmanno K, Newell DR

Publication type: Article

Publication status: Published

Journal: Magnetic Resonance in Chemistry

Year: 1991

Volume: 29

Issue: 13

Pages: S125-S129

Print publication date: 01/10/1991

ISSN (print): 0749-1581

ISSN (electronic): 1097-458X

URL: http://dx.doi.org/10.1002/mrc.1260291321

DOI: 10.1002/mrc.1260291321

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