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Response to mitoxantrone in advanced breast cancer: correlation with expression of c-erbB-2 protein and glutathione S-transferases

Lookup NU author(s): Dr Christopher Wright, Dr Andrew Hall


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Sixty-eight patients with advanced breast cancer were treated with mitoxantrone and clinical responses assessed. Expression of c-erbB-2 protein and cytosolic glutathione S-transferase (GST) isoenzymes pi, alpha and mu by the primary tumours of these patients was determined immunohistochemically, and correlated with treatment response. Tumours overexpressing c-erbB-2 (n = 16, 23%) showed a lower response rate (50% vs 58%) and shorter duration of response to treatment, compared with c-erbB-2 negative tumours. These assciations were not statistically significant but survival following start of treatment was significantly shorter in the c-erbB-2 positive group. For each GST isoenzyme, the response rate and duration of response of the group showing enzyme expression did not differ significantly from those with negatively staining tumours. These data do not support a role for expression of GSTs alone in resistance to mitoxantrone monotherapy in advanced breast cancer. The poorer post treatment survival of patients with c-erbB-2 positive tumours suggests they could be selected for more intensive treatment regimens.

Publication metadata

Author(s): Wright C, Cairns J, Cantwell BJ, Cattan AR, Hall AG, Harris AL, Horne CHW

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1992

Volume: 65

Issue: 2

Pages: 271-274

Print publication date: 01/02/1992

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

PubMed id: 1346748