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C-erbb-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma

Lookup NU author(s): Dr Kun Guo, Dr Felicity May, Dr Mark Bennett, Dr Ian Corbett, Professor Margaret Bassendine, Professor Alastair BurtORCiD


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The c-erbB-2 proto-oncogene encodes a transmembrane protein which is homologous to the epidermal growth factor receptor. This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast cancer. Using this technique we have shown that only 2/26 (8%) of hepatocellular carcinomas, 0/10 (0%) of cholangiocarcinomas and 0/2 (0%) hepatoblastomas overexpressed c-erbB-2 as evidenced by membrane staining. Moreover c-erbB-2 mRNA was not detected in seven hepatocellular carcinomas examined by Northern blot analysis. c-erbB-2 overexpression is, therefore, unlikely to be contributing to the malignant phenotype in hepatocellular carcinoma and cholangiocarcinoma.

Publication metadata

Author(s): Collier JD, Guo K, Mathew J, May FEB, Bennett MK, Corbett IP, Bassendine MF, Burt AD

Publication type: Note

Publication status: Published

Journal: Journal of Hepatology

Year: 1992

Volume: 14

Issue: 2-3

Pages: 377-380

Print publication date: 01/03/1992

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641


DOI: 10.1016/0168-8278(92)90186-S