Browse by author
C-erbb-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma
Lookup NU author(s): Dr Kun Guo, Dr Felicity May, Dr Mark Bennett, Dr Ian Corbett, Professor Margaret Bassendine, Professor Alastair BurtORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The c-erbB-2 proto-oncogene encodes a transmembrane protein which is homologous to the epidermal growth factor receptor. This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast cancer. Using this technique we have shown that only 2/26 (8%) of hepatocellular carcinomas, 0/10 (0%) of cholangiocarcinomas and 0/2 (0%) hepatoblastomas overexpressed c-erbB-2 as evidenced by membrane staining. Moreover c-erbB-2 mRNA was not detected in seven hepatocellular carcinomas examined by Northern blot analysis. c-erbB-2 overexpression is, therefore, unlikely to be contributing to the malignant phenotype in hepatocellular carcinoma and cholangiocarcinoma.
Author(s): Collier JD, Guo K, Mathew J, May FEB, Bennett MK, Corbett IP, Bassendine MF, Burt AD
Publication type: Note
Publication status: Published
Journal: Journal of Hepatology
Year: 1992
Volume: 14
Issue: 2-3
Pages: 377-380
Print publication date: 01/03/1992
ISSN (print): 0168-8278
ISSN (electronic): 1600-0641
URL: http://dx.doi.org/10.1016/0168-8278(92)90186-S
DOI: 10.1016/0168-8278(92)90186-S
