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Toxicity of single-day high-dose vincristine, melphalan, etoposide and carboplatin consolidation with autologous bone marrow rescue in advanced neuroblastoma

Lookup NU author(s): Professor Andrew Pearson, Dr Michael Reid, Emeritus Professor Alan Craft


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16 unselected patients with advanced neuroblastoma were given high-dose consolidation chemotherapy with vincristine, melphalan, etoposide and carboplatin over 5 h followed by autologous bone marrow rescue. 3 patients died from treatment-related toxicity, 2 from disease, 1 is alive with disease and 10 are alive and disease-free a median of 12.5 months (range 2-38 months) after bone marrow rescue. All had bone marrow toxicity, most mucositis and 6 had seizures. Renal failure was unexpectedly severe. In the last 3 patients, administration of carboplatin was delayed by 18 h in an attempt to reduce renal damage. The results show that this regimen produces significant morbidity and has a high mortality. Although the overall outcome is encouraging, too few patients have been studied to gauge its efficacy. Whether such aggressive consolidation is necessary in heavily pretreated children with neuroblastoma remains unknown.

Publication metadata

Author(s): Gordon, S. J., Pearson, A. D. J., Reid, M. M., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 1992

Volume: 28A

Issue: 8-9

Pages: 1319-1323

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852


DOI: 10.1016/0959-8049(92)90508-Y

PubMed id: 1515242


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